DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mio and WDR24

DIOPT Version :9

Sequence 1:	NP_608656.1	Gene:	mio / 33399	FlyBaseID:	FBgn0031399	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	XP_011521001.1	Gene:	WDR24 / 84219	HGNCID:	20852	Length:	879	Species:	Homo sapiens

Alignment Length:	945	Identity:	197/945 - (20%)
Similarity:	309/945 - (32%)	Gaps:	336/945 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 YEVRRKDDHSQKSR------------LPYISVNYL-----------------ANESRYQYA---- 59
            :::||||..|..|.            ||.:|...|                 ||::| :|.
Human   148 FDLRRKDSVSTFSGPREWAMAGCVPILPVLSCRILRLHHSFAHGPMQDAESTANDAR-EYVLQIT 211

  Fly    60 ------------RCVAASYHSDQ--PIIAVGLADG-KVGIC--------NFRD--TYDSSWEYTP 99
                        .|||||.....  |:..:||..| :.|..        :.||  |:.|::|
Human   212 WCPAPGPRLLWRLCVAASLGRSWGCPLYPLGLCSGPQAGQSESVRDVQFSIRDYFTFASTFE--- 273

  Fly   100 RQQRMCTCLAWNELDANILAIGHDRHRNDTCITIWDIERGVPKETANFFGVGESANSIC-WDRNH 163
                          :.|              :.:|||.|  |......|.........| |....
Human   274 --------------NGN--------------VQLWDIRR--PDRCERMFTAHNGPVFCCDWHPED 308

  Fly   164 RTVIA-GMSQKMIKLFDL---RQSNATCQSIQT-KTVQGLSVSPNGNY---LCS-YVDSVITLWD 219
            |..:| |...||:|::|:   |.....|  :|| .:|..:...|...:   .|| .||..|.:||
Human   309 RGWLATGGRDKMVKVWDMTTHRAKEMHC--VQTIASVARVKWRPECRHHLATCSMMVDHNIYVWD 371

  Fly   220 PRNIKSPLRQIQSSKN-HLQIAW-CPTRTSLLSSLQRDSSYITLYDIRSVDTDNSGEIYHVKRQI 282
            .|....|....:..:: ...||| .|...|.|.|..:|||.                ..|:.|..
Human   372 VRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL----------------CQHLFRDA 420

  Fly   283 SPFPARYQHSGKFSFVNCLSWHSRDFERALLLADALNILDFRLPATLHTAHSNR------RKLPL 341
            |....|....|.     |..          |..|    |.|....:|..|.|.|      |:.|:
Human   421 SQPVERANPEGL-----CYG----------LFGD----LAFAAKESLVAAESGRKPYTGDRRHPI 466

  Fly   342 LMQRPLYTPASPTSTAATPTQQQPTSSCSTNSGSSLDFSTPGGSPFNVDLLKPELFEL------D 400
            ..:|.| .||.|.:..|             :|..|:..:.|||......:...|.:.|      :
Human   467 FFKRKL-DPAEPFAGLA-------------SSALSVFETEPGGGGMRWFVDTAERYALAGRPLAE 517

  Fly   401 LVDETRQRALEDYGIKPDNKRFGELHLTPYLRNVWSTLNNVYSEDRLT---------------GL 450
            |.|...:.|.|          .|...:.    ..|:.|..:|....|.               ||
Human   518 LCDHNAKVARE----------LGRNQVA----QTWTMLRIIYCSPGLVPTANLNHSVGKGGSCGL 568

  Fly   451 KATLGINLGHTSEALMASSRIE--------SQVLQWPEGINNSNKLIC----YRSEQRDLALQLC 503
            ......||...:..|.:.:|::        ..||     :::|..||.    ..:|..|:.....
Human   569 PLMNSFNLKDMAPGLGSETRLDRSKGDARSDTVL-----LDSSATLITNEDNEETEGSDVPADYL 628

  Fly   504 GWAFEQELDR--FIDQLYANKEYSRAAMICVFHLKIF---HACNILSSAADNMRDPSMYRITVIA 563
            ....|.|.|.  .:|..:|:.|...    ||...:.|   |.........::::|.:
Human   629 LGDVEGEEDELYLLDPEHAHPEDPE----CVLPQEAFPLRHEIVDTPPGPEHLQDKA-------- 681

  Fly   564 LSSFNADRCSSTWRNQRSSANMQIHDPHLRAVFSFLTMEKDNFDAVLKEE--GVSLSDRMAFACK 626
                ::...|.:..:..|.|.:.       :.||.|::....:|:.|..:  ||.:.|.:.|
Human   682 ----DSPHVSGSEADVASLAPVD-------SSFSLLSVSHALYDSRLPPDFFGVLVRDMLHF--- 732

  Fly   627 YLSETKLADYVAQ-QIQAAIDGGDLNGLLLTGESQDGIDILQSYMDTSFDVQTVALVAINYFRQE 690
                     |..| .:|.|:     :.|::.||.                           .|::
Human   733 ---------YAEQGDVQMAV-----SVLIVLGER---------------------------VRKD 756

  Fly   691 LFEDKRIQYWIASYLDHLNSWGLWEKRAELDIKIESIRPSS---RSSRTVFLSCNFCGKSVSNAL 752
            :.|..: ::|..||:|.|..:.||....|: :|:.:.|..|   ::|.|:.::|:.|
Human   757 IDEQTQ-EHWYTSYIDLLQRFRLWNVSNEV-VKLSTSRAVSCLNQASTTLHVNCSHC-------- 811

  Fly   753 LDEPRPRSTTTSTNRLSSCPSCRKPLPRCSLCLMHMGTMVNMSNGETPTTTPDVPGWQTKPFSKW 817
               .||.|     :|...|..|.:....|::| .|:                 |.|        .
Human   812 ---KRPMS-----SRGWVCDRCHRCASMCAVC-HHV-----------------VKG--------L 842

  Fly   818 FSWCQTCRHGGHTEHIMQWFKQNSECPVSSCNCRC 852
            |.|||.|.||||.:|||:|.:.:|.|| :.|...|
Human   843 FVWCQGCSHGGHLQHIMKWLEGSSHCP-AGCGHLC 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mio	NP_608656.1	WD40 repeat	8..44	CDD:293791	7/27 (26%)
		WD40	60..>266	CDD:295369	56/230 (24%)
		WD40 repeat	60..101	CDD:293791	15/53 (28%)
		WD40	<65..266	CDD:225201	52/225 (23%)
		WD40 repeat	105..148	CDD:293791	6/42 (14%)
		WD40 repeat	155..188	CDD:293791	10/37 (27%)
		WD40 repeat	195..231	CDD:293791	11/39 (28%)
		WD40 repeat	236..284	CDD:293791	12/48 (25%)
		Zn_ribbon_17	741..852	CDD:305234	30/110 (27%)
WDR24	XP_011521001.1	WD40	40..412	CDD:225201	69/299 (23%)
		WD40 repeat	74..118	CDD:293791
		WD40	86..412	CDD:295369	69/299 (23%)
		WD40 repeat	123..160	CDD:293791	5/11 (45%)
		WD40 repeat	177..245	CDD:293791	14/68 (21%)
		WD40 repeat	255..293	CDD:293791	11/70 (16%)
		WD40 repeat	299..341	CDD:293791	13/43 (30%)
		WD40 repeat	343..370	CDD:293791	7/26 (27%)
		WD40 repeat	389..413	CDD:293791	10/39 (26%)
		Zn_ribbon_17	831..876	CDD:305234	22/71 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000