DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mio and MIOS

DIOPT Version :9

Sequence 1:NP_608656.1 Gene:mio / 33399 FlyBaseID:FBgn0031399 Length:867 Species:Drosophila melanogaster
Sequence 2:NP_001357005.1 Gene:MIOS / 54468 HGNCID:21905 Length:875 Species:Homo sapiens


Alignment Length:936 Identity:295/936 - (31%)
Similarity:467/936 - (49%) Gaps:150/936 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSGNTHGLSWFPHFPDKFVSWGQEIHLYEVRRKDDH---------SQKSRLPYISVNYLANESRY 56
            |||....:.|.||..|:||....|:.||.|....:.         |:.|....:|:|     |..
Human     1 MSGTKPDILWAPHHVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLLSIN-----SDT 60

  Fly    57 QYARCVAASYHSD-QPIIAVGLADGKVGICNFRDTYDSSW------EYTPRQQRMCTCLAWNELD 114
            .|.:|||...:.| :.::|||.|:|:|.:.:....::|.:      |:.|:..|.|..||||.||
Human    61 PYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLD 125

  Fly   115 ANILAIGHDRHRNDTCITIWDI-----ERGVPKETANF-----------------FGVGESANSI 157
            :|.||.|.|:||.|..:.||||     ...||.|....                 .|..::..|:
Human   126 SNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVKLSAGETETTLLVTKPLYELGQNDACLSL 190

  Fly   158 CW-DRNHRTVIAGMSQKMIKLFDLRQSNATCQSIQTKTVQGLSVSPN-GNYLCSYVDSVITLWDP 220
            || .|:.:.::||| .:.:.:||||.::.. ..:.||.|||::|.|. .:.:.|:.:..:.:||.
Human   191 CWLPRDQKLLLAGM-HRNLAIFDLRNTSQK-MFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDL 253

  Fly   221 RNIKSP-LRQIQSSKNHLQIAWCPTRTSLLSSLQRDSSYITLYDIRSVDT--DNSGEIYHVKRQI 282
            |..:.| |...:..|...::|||||||.||::|.|||:.|.|||::...|  .:..|...::|.:
Human   254 RKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSV 318

  Fly   283 SPFPARYQHSGKFSFVNCLSWHSRDFERALLLADALNILDFRLPATLHTAHSNRRKLPLLMQRPL 347
            .|..         :::...:||.....|.:::.....:.||.:...:..|.|....|.....|.|
Human   319 QPCD---------NYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHL 374

  Fly   348 YTPASPTSTAATPTQQQPTSSCSTNSGSSLDFSTPGGSPFNVDLLKPELFELDLVDETRQRALED 412
            |               :.|...:.||                       .|.|:..:.|.|||..
Human   375 Y---------------ECTEEENDNS-----------------------LEKDIATKMRLRALSR 401

  Fly   413 YGIKPDNKRFGELHL-----TPYLRNVWSTLN--NVYSEDR------------LTGLKATLGINL 458
            ||:  |.::....|:     .|.|:::|.||:  ..|:||.            ..|:|:.:..:|
Human   402 YGL--DTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDMDQKSPGNKGSLVYAGIKSIVKSSL 464

  Fly   459 GHTSEALMASSRIESQVLQWPEGINNSNKLICYRSEQRDLALQLCGW---AFEQELDRFIDQLYA 520
            |     ::.|||.....|.....|.|.|       |:|.||||||||   ..:.::..|::.|..
Human   465 G-----MVESSRHNWSGLDKQSDIQNLN-------EERILALQLCGWIKKGTDVDVGPFLNSLVQ 517

  Fly   521 NKEYSRAAMICVFHLKIFHACNILSSAADNMRDPSMYRITVIALSSFNADRCSSTWRNQRSSANM 585
            ..|:.|||.:.:|:|.|..|..||:..|.:.:......:..:|||.: .|..:|.||...|:..:
Human   518 EGEWERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGY-TDEKNSLWREMCSTLRL 581

  Fly   586 QIHDPHLRAVFSFLTMEKDNFDAVLKEEGVSLSDRMAFACKYLSETKLADYVAQQIQAAIDGGDL 650
            |:::|:|..:|:|||.|..::|.||.|..|::.||:|||||:||:|:|..|:.:......:.|:|
Human   582 QLNNPYLCVMFAFLTSETGSYDGVLYENKVAVRDRVAFACKFLSDTQLNRYIEKLTNEMKEAGNL 646

  Fly   651 NGLLLTGESQDGIDILQSYMDTSFDVQTVALVAINYFRQELFEDKRIQYWIASYLDHLNSWGLWE 715
            .|:||||.::||:|:::||:|.:.||||.:...:.....::.:|:|:||||.:|.:.|::|..|.
Human   647 EGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWH 711

  Fly   716 KRAELDIKIESIRPSSRSSRTVFLSCNFCGKSVSNALLDEPRPR--------STTTSTNRLSSCP 772
            ||||.||....:.|||:....||:||||||||:|.:....|...        |.:.:.::::|||
Human   712 KRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSAVPHQGRGFSQYGVSGSPTKSKVTSCP 776

  Fly   773 SCRKPLPRCSLCLMHMGTMVNMSNGETPT-----TTPDVPGWQTKPFSKWFSWCQTCRHGGHTEH 832
            .||||||||:|||::|||.|:...|.|.:     .:.|.   :...|:.||:||..||||||..|
Human   777 GCRKPLPRCALCLINMGTPVSSCPGGTKSDEKVDLSKDK---KLAQFNNWFTWCHNCRHGGHAGH 838

  Fly   833 IMQWFKQNSECPVSSCNCRCFDMDGT 858
            ::.||:.::|||||:|.|:|..:|.|
Human   839 MLSWFRDHAECPVSACTCKCMQLDTT 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mioNP_608656.1 WD40 repeat 8..44 CDD:293791 12/44 (27%)
WD40 60..>266 CDD:295369 79/237 (33%)
WD40 repeat 60..101 CDD:293791 13/47 (28%)
WD40 <65..266 CDD:225201 76/232 (33%)
WD40 repeat 105..148 CDD:293791 22/64 (34%)
WD40 repeat 155..188 CDD:293791 11/33 (33%)
WD40 repeat 195..231 CDD:293791 11/37 (30%)
WD40 repeat 236..284 CDD:293791 20/49 (41%)
Zn_ribbon_17 741..852 CDD:305234 52/123 (42%)
MIOSNP_001357005.1 WD 1 58..100 13/41 (32%)
WD40 repeat 64..105 CDD:293791 11/40 (28%)
WD40 <84..297 CDD:356469 69/214 (32%)
WD 2 111..155 20/43 (47%)
WD40 repeat 116..176 CDD:293791 22/59 (37%)
WD 3 182..221 12/40 (30%)
WD40 repeat 188..220 CDD:293791 11/33 (33%)
WD 4 223..261 12/37 (32%)
WD40 repeat 227..264 CDD:293791 11/36 (31%)
WD 5 265..306 19/40 (48%)
WD40 repeat 270..318 CDD:293791 20/47 (43%)
WD40 repeat 325..347 CDD:293791 3/21 (14%)
WD 6 395..437 13/43 (30%)
mRING-H2-C3H3C2_Mio 782..858 CDD:319605 35/78 (45%)
modified RING-H2 finger (C3H3C2-type) 785..854 CDD:319605 30/71 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144954
Domainoid 1 1.000 230 1.000 Domainoid score I2468
eggNOG 1 0.900 - - E1_KOG1008
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H10371
Inparanoid 1 1.050 450 1.000 Inparanoid score I1619
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55445
OrthoDB 1 1.010 - - D446979at33208
OrthoFinder 1 1.000 - - FOG0005795
OrthoInspector 1 1.000 - - oto90065
orthoMCL 1 0.900 - - OOG6_104395
Panther 1 1.100 - - LDO PTHR16453
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1695
SonicParanoid 1 1.000 - - X4772
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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