DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mio and mios

DIOPT Version :9

Sequence 1:	NP_608656.1	Gene:	mio / 33399	FlyBaseID:	FBgn0031399	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_958490.1	Gene:	mios / 393208	ZFINID:	ZDB-GENE-040426-856	Length:	876	Species:	Danio rerio

Alignment Length:	929	Identity:	291/929 - (31%)
Similarity:	457/929 - (49%)	Gaps:	136/929 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SGNTHGLSWFPHFPDKFVSWGQEIHLYEVRRKDDHSQKSRLPYIS----VNYLANESRYQYARCV 62
            ||....:.|.||..|::|....|:.||.:........|:....:|    ...||..|...:.:||
Zfish     3 SGYKPDILWSPHHADRYVICDTELSLYRIGPSGSSETKAGALQLSEETAATLLAINSDTPFMKCV 67

  Fly    63 A-ASYHSDQPIIAVGLADGKVGICNFRDTYDS------SWEYTPRQQRMCTCLAWNELDANILAI 120
            | ...|..:.::|||..:|:|.:.:...:::|      ..|:.|:..|.|..||||.:|:|.||.
Zfish    68 AWYPKHEPECLLAVGHTNGRVVLTSLGQSHNSKSKDLAGKEFVPKHARQCNTLAWNPVDSNWLAA 132

  Fly   121 GHDRHRNDTCITIWDIE-----RGVPKETANF----------------FGVGESANSICW-DRNH 163
            |.|:||.|..:.||||.     ..||.|....                .|..::..|:|| .|:|
Zfish   133 GLDKHRADFSVLIWDISSKFSPEAVPAEKVRLSGDADSGLLVTKPLYELGQNDACLSLCWLPRDH 197

  Fly   164 -RTVIAGMSQKMIKLFDLRQSNATCQS--IQTKTVQGLSVSPN-GNYLCSYVDSVITLWDPRNIK 224
             :.::||| .:.:.:||||.   |.|.  :.||.:||::|.|: .:.:.||.:..:.:||.|..:
Zfish   198 QKLLLAGM-HRNLAIFDLRN---TSQKTFVNTKAIQGVTVDPHFQDRVASYFEGQVAIWDLRKFE 258

  Fly   225 SPLRQIQSSKNHL-QIAWCPTRTSLLSSLQRDSSYITLYDIRSVDTDNSGEIYH--VKRQISPFP 286
            .|:..:......| ::||||||..||::|.|||:.|.|||::........|:..  ::|.:.|..
Zfish   259 KPVFTLNEQPKPLTKVAWCPTRMGLLATLTRDSNIIRLYDMQHTPMPFGDEVEPTIMERGVQPCS 323

  Fly   287 ARYQHSGKFSFVNCLSWHSRDFERALLLADALNILDFRLPATLHTAHSNRRKLPLLMQRPLYTPA 351
            .        |.::..:||.....|.::::.:..:.||.|...:..|.|:...|.....|.||
Zfish   324 E--------SIISSFAWHPSAQNRMVVVSPSRVMNDFTLFERISLAWSSTTSLMWACGRHLY--- 377

  Fly   352 SPTSTAATPTQQQPTSSCSTNSGSSLDFSTPGGSPFNVDLLKPELFELDLVDETRQRALEDYGIK 416
                            .|:.:||.:.:                  .|.|:..:.|:||...||
Zfish   378 ----------------ECAEDSGQAAE------------------AEKDIATKMRERAQSRYG-- 406

  Fly   417 PDNKRFGELHL-----TPYLRNVWSTLN-------NVYSEDRLTGLKATL---GI-NLGHTSEAL 465
            .|..:....|:     .|.||::|.||:       ||  |.:....|.:|   || |:..:|...
Zfish   407 HDTVQVWRNHVLAGGDDPQLRSLWYTLHFMKQYTENV--EQKQQSNKQSLIYSGIKNIVKSSSGT 469

  Fly   466 MASSRIESQVLQWPEGINNSNKLICYRSEQRDLALQLCGWAF---EQELDRFIDQLYANKEYSRA 527
            ..:.|.      | .|.:....:..:.||:|.||||||||..   :.:::.|:..|....|:.||
Zfish   470 TETRRC------W-SGSDRQTDVPRFHSEERSLALQLCGWISQGPDTDVEPFLKSLEQEGEWERA 527

  Fly   528 AMICVFHLKIFHACNILSSAADNMRDPSMYRITVIALSSFNADRCSSTWRNQRSSANMQIHDPHL 592
            |.:.:|:|.|..|..||:..|.:.:......:..:|||.: .|..:|.||...||..:|:..|:|
Zfish   528 AAVALFNLDIRRAIQILNKGASSEKGDLNLNVVAMALSGY-TDEKNSLWREMCSSLRLQLKKPYL 591

  Fly   593 RAVFSFLTMEKDNFDAVLKEEGVSLSDRMAFACKYLSETKLADYVAQQIQAAIDGGDLNGLLLTG 657
            ..:|:|||.|...:|.||.|..|::.||:||||.:|::.:|..|:.:......:.|:|.|:||||
Zfish   592 CIMFAFLTSEPGAYDGVLYESRVAVRDRVAFACMFLNDAQLPRYIDKLTNEMKEAGNLEGILLTG 656

  Fly   658 ESQDGIDILQSYMDTSFDVQTVALVAINYFRQELFEDKRIQYWIASYLDHLNSWGLWEKRAELDI 722
            .::||:|:::||:|.:.||||.:...:.....|:.:|.|:|.||.:|.:.|::|..|.||||.||
Zfish   657 LTKDGVDLMESYVDRTGDVQTASFCMLKGSPGEVLKDPRVQCWIENYRNLLDAWRFWHKRAEFDI 721

  Fly   723 KIESIRPSSRSSRTVFLSCNFCGKSVSNALLDEPRPR--------STTTSTNRLSSCPSCRKPLP 779
            ....:.|||:....||:||||||||:|.:....|...        |.:.:.::::|||.||||||
Zfish   722 HRSKLDPSSKPLAQVFVSCNFCGKSISYSCSAMPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLP 786

  Fly   780 RCSLCLMHMGTMVNMSNG-----ETPTTTPDVPGWQTKPFSKWFSWCQTCRHGGHTEHIMQWFKQ 839
            ||:||||:|||.|:...|     |....|.|.   :...|:.||:||..||||||..|::.||:.
Zfish   787 RCALCLMNMGTPVSSCPGTGKADEKADLTRDK---KLAQFNNWFTWCHNCRHGGHAGHMLSWFRD 848

  Fly   840 NSECPVSSCNCRCFDMDGT 858
            :||||||:|.|:|..:|.|
Zfish   849 HSECPVSACTCKCMQLDTT 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mio	NP_608656.1	WD40 repeat	8..44	CDD:293791	9/35 (26%)
		WD40	60..>266	CDD:295369	78/239 (33%)
		WD40 repeat	60..101	CDD:293791	12/47 (26%)
		WD40	<65..266	CDD:225201	75/233 (32%)
		WD40 repeat	105..148	CDD:293791	21/63 (33%)
		WD40 repeat	155..188	CDD:293791	13/34 (38%)
		WD40 repeat	195..231	CDD:293791	10/36 (28%)
		WD40 repeat	236..284	CDD:293791	19/50 (38%)
		Zn_ribbon_17	741..852	CDD:305234	55/123 (45%)
mios	NP_958490.1	WD 1	59..101		11/41 (27%)
		WD40 repeat	65..106	CDD:293791	10/40 (25%)
		WD40	98..370	CDD:225201	82/283 (29%)
		WD 2	112..156		19/43 (44%)
		WD40	113..>299	CDD:295369	65/189 (34%)
		WD40 repeat	117..158	CDD:293791	18/40 (45%)
		WD 3	182..222		15/43 (35%)
		WD40 repeat	188..221	CDD:293791	14/36 (39%)
		WD 4	224..262		12/37 (32%)
		WD40 repeat	228..265	CDD:293791	10/36 (28%)
		WD 5	266..307		17/40 (43%)
		WD40 repeat	271..315	CDD:293791	18/43 (42%)
		WD 6	400..440		12/41 (29%)
		Zn_ribbon_17	740..861	CDD:305234	55/123 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578201
Domainoid	1	1.000	218	1.000	Domainoid score	I2604
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10371
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1651
OMA	1	1.010	-	-		QHG55445
OrthoDB	1	1.010	-	-		D446979at33208
OrthoFinder	1	1.000	-	-		FOG0005795
OrthoInspector	1	1.000	-	-		oto40389
orthoMCL	1	0.900	-	-		OOG6_104395
Panther	1	1.100	-	-	LDO	PTHR16453
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1695
SonicParanoid	1	1.000	-	-		X4772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940