DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mio and SPAC12G12.01c

DIOPT Version :9

Sequence 1:	NP_608656.1	Gene:	mio / 33399	FlyBaseID:	FBgn0031399	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_001342800.1	Gene:	SPAC12G12.01c / 3361381	PomBaseID:	SPAC12G12.01c	Length:	905	Species:	Schizosaccharomyces pombe

Alignment Length:	981	Identity:	248/981 - (25%)
Similarity:	396/981 - (40%)	Gaps:	244/981 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DHSQKSRLPYISVNYLANESRY--------------------QYARCVAASYHSDQPIIAVGLAD 79
            :.|:|....|..||..::|.||                    :..:|: .|:|.:..|:..|.:.
pombe     3 NRSKKRNGCYFWVNGSSDEIRYVAVKASPKVNWKTHIIWRSLKNVKCI-DSFHGNNEILGAGSST 66

  Fly    80 GKVGICNFRDTYDSSWEY----TPRQQRMCTCLAWNELDANILAIGHDRHRNDTCITIWDIER-- 138
            |.:.:.:.:..     |:    ||...|.|..||::|.:.  |..|..:.||::.:.:||:..
pombe    67 GNISLLSVKHP-----EFQAVVTPGYARPCNSLAFSETEH--LVAGFAKSRNESSLKLWDLNSLL 124

  Fly   139 GVPK-----ETANFFGVGESANSICWDRNHRTVIAGMSQKMIKLFDLRQSNATCQSIQTKTVQGL 198
            ..||     :::...||    :|:|:.::...::.|.:.:.:.:.|.||...:..|:.|:....:
pombe   125 SDPKSSPLMQSSTLDGV----SSVCYKKDTPLLLTGSTSRSVHIIDTRQQLDSVSSVNTQYYSNI 185

  Fly   199 SVSP-NGNYLC--SYVDSVITLWDPRNIKSPLRQIQSSKNHLQI--------------------A 240
            .|.| :.||..  || |..|.::|.|..|        |.|:|||                    .
pombe   186 VVDPFSPNYFAANSY-DGDIAIFDTRYFK--------SDNYLQIILRNENKKPKNPQLFALKYSE 241

  Fly   241 WCPTRTSLLSSLQRDSSYITLYDIRSVDTDNSGEI-------YHVKRQISP-------------- 284
            |.|.:.::||     ::.|||..:......|.|..       |..|..:.|
pombe   242 WKPGQLAVLS-----NNSITLRQLLPCVNGNEGSANNSVFVNYEKKYPVKPNSQCSGIDFFTPST 301

  Fly   285 -FPARYQHSGKFSFVNCLSWHSRDFERALLLADALNILDFRLPATLHTAHSNRRKLPLLMQRPLY 348
             ||...|..|..:            |:..|.:....::.|..........|.:.||..|...|..
pombe   302 AFPTHVQILGVIN------------EQPKLFSVHDEVIPFSFNPYNDLIFSFKEKLYPLNSSPFN 354

  Fly   349 T----PASPTSTAATPTQQQPTSSCST--------NSGSSLDFSTPGGSPFNVDLLKPELFELDL 401
            |    |....|..........:||||:        ||.:|.|      |...|.|....:...|:
pombe   355 TLSDVPQFDVSEFVDENSFDSSSSCSSKVFLTTRNNSINSED------SAHEVLLSYNRVLGSDI 413

  Fly   402 VDETRQRALEDYGIKPDNKRFGELHLTPYLRNVWS--TLNNVYSEDRLTG--------LKATLGI 456
            ......|..:.|..  |:::..||....||:::||  .|::..||:.|.|        .:..|||
pombe   414 QGTILDRVKKGYQF--DSQKNSELVSDLYLKDLWSWIHLSHRQSEESLFGDTGDTDFSYQGALGI 476

  Fly   457 -----NLGHTSEALMA--SSRIESQVLQWPEGINNSNKLICYRSEQ-----RDLALQLCGWAFEQ 509
                 .|...|:...|  |..:|.::|:....:.....|..:.|.|     |.|||..||.....
pombe   477 WFMDTELTSMSDVFEAKESKFLEKKILRLARDVIERLDLDIFTSIQTKRPLRQLALLACGLGMSN 541

  Fly   510 ELDRFID--QLYANKEYSRAAMICVFHLKIFHACNILSSAADNMRDPSM----YRITVIALSSFN 568
            : |..::  :|....|:.:||.:.:||.||.:...||||..:..:..|.    | ||...||:|.
pombe   542 D-DLLLEIRRLIRKNEHVKAAGLALFHGKIENVVRILSSGNELEKTISTAVAGY-ITSQGLSNFG 604

  Fly   569 ADRCSSTWRNQRSSANMQIHDPHLRAVFSFLTMEKDNFDAVLKEEGVSLSDRMAFACKYLSETKL 633
            :|   |.|:....:.:.::.||:|||:|::::  ..::..||.|..:||.||:..|.::|.:..|
pombe   605 SD---SLWKEMSRNLSTELEDPYLRAIFAYVS--NSDWRDVLDEVSLSLKDRLGIALRFLPDDDL 664

  Fly   634 ADYVAQQIQAAIDGGDLNGLLLTGESQDGIDILQSYMDTSFDVQTVALVAINYFRQELFEDKRIQ 698
            ::|:.......:..||..||||||.:..|:::||:|:|.:.||||.||:|. :...:.|.|||.:
pombe   665 SNYLCDLCHTTVQSGDPEGLLLTGLTPLGMELLQNYIDHTSDVQTAALIAA-FVVPKKFLDKRAE 728

  Fly   699 YWIASYLDHLNSWGLWEKRAELD-------------IKIESIRPSSRSSRTVFLSCNFCGKSVSN 750
            .|..||.:.||.|.|:.:||:.|             |..::..||.|      :.||||.|.:.
pombe   729 DWTESYRELLNRWKLYRERAKFDIFRTELSKNHTGEITRKATEPSIR------IICNFCRKPIF- 786

  Fly   751 ALLDEPRPRSTTTSTNRL------------------SSCPSCRKPLPRCSLCLMHMGTMVNMSNG 797
                   |.|.....|.|                  .|||.|.:|||:||:|...:|
pombe   787 -------PFSNRNECNNLPTPIQRGVSKAGPAKHLGKSCPHCGQPLPKCSVCGFSLG-------- 836

  Fly   798 ETPTTTPDVP---GWQTKP-------------FSKWFSWCQTCRHGGHTEHIMQWFKQNSECPVS 846
                 ..|||   .:..||             |..|||:|..|.||.|..|..:||..::.|||.
pombe   837 -----DEDVPQKDDFSQKPQNYVKEVNLQKSRFGLWFSFCLNCGHGAHASHASEWFSTHTICPVP 896

  Fly   847 SCNCRC 852
            :|:|.|
pombe   897 NCDCEC 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mio	NP_608656.1	WD40 repeat	8..44	CDD:293791	2/8 (25%)
		WD40	60..>266	CDD:295369	55/239 (23%)
		WD40 repeat	60..101	CDD:293791	9/44 (20%)
		WD40	<65..266	CDD:225201	54/234 (23%)
		WD40 repeat	105..148	CDD:293791	12/49 (24%)
		WD40 repeat	155..188	CDD:293791	6/32 (19%)
		WD40 repeat	195..231	CDD:293791	11/38 (29%)
		WD40 repeat	236..284	CDD:293791	14/74 (19%)
		Zn_ribbon_17	741..852	CDD:305234	42/144 (29%)
SPAC12G12.01c	NP_001342800.1	WD40	15..>213	CDD:330360	47/210 (22%)
		WD40 repeat	48..86	CDD:293791	8/43 (19%)
		WD40 repeat	91..134	CDD:293791	12/44 (27%)
		WD40 repeat	142..175	CDD:293791	6/32 (19%)
		zinc_ribbon_16	778..905	CDD:293639	43/146 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	76	1.000	Domainoid score	I2459
eggNOG	1	0.900	-	-		E1_KOG1008
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I870
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005795
OrthoInspector	1	1.000	-	-		oto101291
orthoMCL	1	0.900	-	-		OOG6_104395
Panther	1	1.100	-	-	LDO	PTHR16453
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1695
SonicParanoid	1	1.000	-	-		X4772
TreeFam	0	0.000	Not matched by this tool.
	11	10.890