Protein Alignment mio and Mios

DIOPT Version :10

• Sequence 1: NP_608656.1
• Gene: mio / 33399
• FlyBaseID: FBgn0031399
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: XP_036022022.1
• Gene: Mios / 252875
• MGIID: 2182066
• Length: 893
• Species: Mus musculus
• Alignment Length: 953
• Identity: 294/953 - (30%)
• Similarity: 464/953 - (48%)
• Gaps: 166/953 - (17%)

  Fly     1 MSGNTHGLSWFPHFPDKFVSWGQEIHLYEVRRKDDH---------SQKSRLPYISVNYLANESRY 56
            |||....:.|.||..|:||....|:.||.|....:.         |:.|....:|:|     |..
Mouse     1 MSGTKPDILWAPHQVDRFVVCDSELSLYHVESAVNSELKAGSLRLSEDSAATLLSIN-----SDT 60

  Fly    57 QYARCVAASYHSD-QPIIAVGLADGKVGICNFRDTYDSSW------EYTPRQQRMCTCLAWNELD 114
            .|.:|||...:.| :.::|||.|:|:|.:.:....::|.:      |:.|:..|.|..||||.||
Mouse    61 PYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLD 125

  Fly   115 ANILAIGHDRHRNDTCITIWDI-----ERGVPKETANF-----------------FGVGESANSI 157
            :|.||.|.|:||.|..:.||||     ...||.|....                 .|..:::.|:
Mouse   126 SNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVRLSAGEAETTLLVTKPLYELGQNDASLSL 190

  Fly   158 CW-DRNHRTVIAGMSQKMIKLFDLRQSNATCQSIQTKTVQGLSVSPN-GNYLCSYVDSVITLWDP 220
            || .|:.:.::||| .:.:.:||||.::.. ..:.||.|||::|.|. .:.:.|:.:..:.:||.
Mouse   191 CWLPRDQKLLLAGM-HRNLAIFDLRNTSQK-MFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDL 253

  Fly   221 RNIKSP-LRQIQSSKNHLQIAWCPTRTSLLSSLQRDSSYITLYDIRSVDT--DNSGEIYHVKRQI 282
            |..:.| |...:..|...::|||||||.||::|.|||:.|.|||::...|  .:..|...::|.:
Mouse   254 RKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSV 318

  Fly   283 SPFPARYQHSGKFSFVNCLSWHSRDFERALLLADALNILDFRLPATLHTAHSNRRKLPLLMQRPL 347
            .|..         :::...:||.....|.:::.....:.||.:...:..|.|....|.....|.|
Mouse   319 QPCD---------NYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHL 374

  Fly   348 YTPASPTSTAATPTQQQPTSSCSTNSGSSLDFSTPGGSPFNVDLLKPELFELDLVDETRQRALED 412
            |..|...               |.||                       .|.|:..:.|.|||..
Mouse   375 YECAEEE---------------SDNS-----------------------LEKDIATKMRLRALSR 401

  Fly   413 YGIKPDNKRFGELHL-----TPYLRNVWSTLN--NVYSEDR------------LTGLKATLGINL 458
            ||:  |.::....|:     .|.|:::|.||:  ..|:||.            ..|:|:.:..:|
Mouse   402 YGL--DTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDNDQKSPGNKGSLVYAGIKSIVKSSL 464

  Fly   459 GHTSEALMASSRIESQVLQWPEGINNSNKLICYRSEQRDLALQLCGW---AFEQELDRFIDQLYA 520
            |     ::.|||.....|.....|.|.|       |:|.||||||||   ..:.::..|::.|..
Mouse   465 G-----MVESSRHNWSGLDKQTDIQNLN-------EERILALQLCGWIKKGTDVDVGPFLNSLVQ 517

  Fly   521 NKEYSRAAMICVFHLKIFHACNILSSAADNMRDPSMYRITVIALSSFNADRCSSTWRNQRSSANM 585
            ..|:.|||.:.:|:|.|..|..||:..|.:.:......:..:|||.: .|..:|.||...|:..:
Mouse   518 EGEWERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGY-TDEKNSLWREMCSTLRL 581

  Fly   586 QIHDPHLRAVFSFLTMEKDNFDAVLKEEGVSLSDRMAFACKYLSETKLADYVAQQIQAAIDGGDL 650
            |:::|:|..:|:|||.|...:|.||.|..|::.||:|||||:|.:.:|..|:.:......:.|:|
Mouse   582 QLNNPYLCVMFAFLTSEAGAYDGVLYENKVAVRDRVAFACKFLGDAQLNKYIEKLTNEMKEAGNL 646

  Fly   651 NGLLLTGESQDGIDILQSYMDTSFDVQTVALVAINYFRQELFEDKRIQYWIASYLDHLNSWGLWE 715
            .|:||||.::||:|:::||:|.:.||||.:...:.....::.:|:|:||||.:|.:.|::|..|.
Mouse   647 EGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWH 711

  Fly   716 KRAELDIKIESIRPSSRSSRTVFLSCNFCGKSVSNALLDEPRPR--------STTTSTNRLSSCP 772
            ||||.||....:.|||:....||:||||||||:|.:....|...        |.:.:.::::|||
Mouse   712 KRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSSVPHQGRGFSQYGVSGSPTKSKVTSCP 776

  Fly   773 SCRKPLPRCSLCLMHMGTMVNMSNGETPTTTPDV----------------------PGWQTKPFS 815
            .||||||||:|||::|||.|:...|  .||..::                      ...:...|:
Mouse   777 GCRKPLPRCALCLINMGTPVSSCPG--MTTAQNISLNSVFLHGASGSKSDEKVDLSKDKKLAQFN 839

  Fly   816 KWFSWCQTCRHGGHTEHIMQWFKQNSECPVSSCNCRCFDMDGT 858
            .||:||..||||||..|::.||:.::|||||:|.|:|..:|.|
Mouse   840 NWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTCKCMQLDTT 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mio	NP_608656.1	WD40 repeat	8..44	CDD:293791	12/44 (27%)
		WD40	60..>266	CDD:475233	79/237 (33%)
		WD40 repeat	60..101	CDD:293791	13/47 (28%)
		WD40 repeat	105..148	CDD:293791	22/64 (34%)
		WD40 repeat	155..188	CDD:293791	11/33 (33%)
		WD40 repeat	195..231	CDD:293791	11/37 (30%)
		WD40 repeat	236..284	CDD:293791	20/49 (41%)
		mRING-H2-C3H3C2_Mio	778..852	CDD:438352	35/95 (37%)
Mios	XP_036022022.1	WD40 repeat	64..105	CDD:293791	11/40 (28%)
		WD40	<84..327	CDD:441893	75/253 (30%)
		WD40 repeat	116..176	CDD:293791	22/59 (37%)
		WD40 repeat	188..220	CDD:293791	11/33 (33%)
		WD40 repeat	227..264	CDD:293791	11/36 (31%)
		WD40 repeat	270..318	CDD:293791	20/47 (43%)
		WD40 repeat	325..347	CDD:293791	3/21 (14%)
		mRING-H2-C3H3C2_Mio	782..876	CDD:438352	35/95 (37%)