DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mio and Mios

DIOPT Version :9

Sequence 1:	NP_608656.1	Gene:	mio / 33399	FlyBaseID:	FBgn0031399	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	XP_036022022.1	Gene:	Mios / 252875	MGIID:	2182066	Length:	893	Species:	Mus musculus

Alignment Length:	953	Identity:	294/953 - (30%)
Similarity:	464/953 - (48%)	Gaps:	166/953 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGNTHGLSWFPHFPDKFVSWGQEIHLYEVRRKDDH---------SQKSRLPYISVNYLANESRY 56
            |||....:.|.||..|:||....|:.||.|....:.         |:.|....:|:|     |..
Mouse     1 MSGTKPDILWAPHQVDRFVVCDSELSLYHVESAVNSELKAGSLRLSEDSAATLLSIN-----SDT 60

  Fly    57 QYARCVAASYHSD-QPIIAVGLADGKVGICNFRDTYDSSW------EYTPRQQRMCTCLAWNELD 114
            .|.:|||...:.| :.::|||.|:|:|.:.:....::|.:      |:.|:..|.|..||||.||
Mouse    61 PYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLD 125

  Fly   115 ANILAIGHDRHRNDTCITIWDI-----ERGVPKETANF-----------------FGVGESANSI 157
            :|.||.|.|:||.|..:.||||     ...||.|....                 .|..:::.|:
Mouse   126 SNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVRLSAGEAETTLLVTKPLYELGQNDASLSL 190

  Fly   158 CW-DRNHRTVIAGMSQKMIKLFDLRQSNATCQSIQTKTVQGLSVSPN-GNYLCSYVDSVITLWDP 220
            || .|:.:.::||| .:.:.:||||.::.. ..:.||.|||::|.|. .:.:.|:.:..:.:||.
Mouse   191 CWLPRDQKLLLAGM-HRNLAIFDLRNTSQK-MFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDL 253

  Fly   221 RNIKSP-LRQIQSSKNHLQIAWCPTRTSLLSSLQRDSSYITLYDIRSVDT--DNSGEIYHVKRQI 282
            |..:.| |...:..|...::|||||||.||::|.|||:.|.|||::...|  .:..|...::|.:
Mouse   254 RKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSV 318

  Fly   283 SPFPARYQHSGKFSFVNCLSWHSRDFERALLLADALNILDFRLPATLHTAHSNRRKLPLLMQRPL 347
            .|..         :::...:||.....|.:::.....:.||.:...:..|.|....|.....|.|
Mouse   319 QPCD---------NYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHL 374

  Fly   348 YTPASPTSTAATPTQQQPTSSCSTNSGSSLDFSTPGGSPFNVDLLKPELFELDLVDETRQRALED 412
            |..|...               |.||                       .|.|:..:.|.|||..
Mouse   375 YECAEEE---------------SDNS-----------------------LEKDIATKMRLRALSR 401

  Fly   413 YGIKPDNKRFGELHL-----TPYLRNVWSTLN--NVYSEDR------------LTGLKATLGINL 458
            ||:  |.::....|:     .|.|:::|.||:  ..|:||.            ..|:|:.:..:|
Mouse   402 YGL--DTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDNDQKSPGNKGSLVYAGIKSIVKSSL 464

  Fly   459 GHTSEALMASSRIESQVLQWPEGINNSNKLICYRSEQRDLALQLCGW---AFEQELDRFIDQLYA 520
            |     ::.|||.....|.....|.|.|       |:|.||||||||   ..:.::..|::.|..
Mouse   465 G-----MVESSRHNWSGLDKQTDIQNLN-------EERILALQLCGWIKKGTDVDVGPFLNSLVQ 517

  Fly   521 NKEYSRAAMICVFHLKIFHACNILSSAADNMRDPSMYRITVIALSSFNADRCSSTWRNQRSSANM 585
            ..|:.|||.:.:|:|.|..|..||:..|.:.:......:..:|||.: .|..:|.||...|:..:
Mouse   518 EGEWERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGY-TDEKNSLWREMCSTLRL 581

  Fly   586 QIHDPHLRAVFSFLTMEKDNFDAVLKEEGVSLSDRMAFACKYLSETKLADYVAQQIQAAIDGGDL 650
            |:::|:|..:|:|||.|...:|.||.|..|::.||:|||||:|.:.:|..|:.:......:.|:|
Mouse   582 QLNNPYLCVMFAFLTSEAGAYDGVLYENKVAVRDRVAFACKFLGDAQLNKYIEKLTNEMKEAGNL 646

  Fly   651 NGLLLTGESQDGIDILQSYMDTSFDVQTVALVAINYFRQELFEDKRIQYWIASYLDHLNSWGLWE 715
            .|:||||.::||:|:::||:|.:.||||.:...:.....::.:|:|:||||.:|.:.|::|..|.
Mouse   647 EGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWH 711

  Fly   716 KRAELDIKIESIRPSSRSSRTVFLSCNFCGKSVSNALLDEPRPR--------STTTSTNRLSSCP 772
            ||||.||....:.|||:....||:||||||||:|.:....|...        |.:.:.::::|||
Mouse   712 KRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSSVPHQGRGFSQYGVSGSPTKSKVTSCP 776

  Fly   773 SCRKPLPRCSLCLMHMGTMVNMSNGETPTTTPDV----------------------PGWQTKPFS 815
            .||||||||:|||::|||.|:...|  .||..::                      ...:...|:
Mouse   777 GCRKPLPRCALCLINMGTPVSSCPG--MTTAQNISLNSVFLHGASGSKSDEKVDLSKDKKLAQFN 839

  Fly   816 KWFSWCQTCRHGGHTEHIMQWFKQNSECPVSSCNCRCFDMDGT 858
            .||:||..||||||..|::.||:.::|||||:|.|:|..:|.|
Mouse   840 NWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTCKCMQLDTT 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mio	NP_608656.1	WD40 repeat	8..44	CDD:293791	12/44 (27%)
		WD40	60..>266	CDD:295369	79/237 (33%)
		WD40 repeat	60..101	CDD:293791	13/47 (28%)
		WD40	<65..266	CDD:225201	76/232 (33%)
		WD40 repeat	105..148	CDD:293791	22/64 (34%)
		WD40 repeat	155..188	CDD:293791	11/33 (33%)
		WD40 repeat	195..231	CDD:293791	11/37 (30%)
		WD40 repeat	236..284	CDD:293791	20/49 (41%)
		Zn_ribbon_17	741..852	CDD:305234	52/140 (37%)
Mios	XP_036022022.1	WD40 repeat	64..105	CDD:293791	11/40 (28%)
		WD40	112..>299	CDD:421866	66/188 (35%)
		WD40 repeat	116..176	CDD:293791	22/59 (37%)
		WD40 repeat	188..220	CDD:293791	11/33 (33%)
		WD40 repeat	227..264	CDD:293791	11/36 (31%)
		WD40 repeat	270..318	CDD:293791	20/47 (43%)
		WD40 repeat	325..347	CDD:293791	3/21 (14%)
		mRING-H2-C3H3C2_Mio	782..876	CDD:319605	35/95 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835057
Domainoid	1	1.000	226	1.000	Domainoid score	I2514
eggNOG	1	0.900	-	-		E1_KOG1008
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10371
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1630
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55445
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005795
OrthoInspector	1	1.000	-	-		oto93641
orthoMCL	1	0.900	-	-		OOG6_104395
Panther	1	1.100	-	-	LDO	PTHR16453
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1695
SonicParanoid	1	1.000	-	-		X4772
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790