DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uch and Uchl4

DIOPT Version :9

Sequence 1:	NP_001188681.1	Gene:	Uch / 33397	FlyBaseID:	FBgn0010288	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_291085.1	Gene:	Uchl4 / 93841	MGIID:	1890440	Length:	233	Species:	Mus musculus

Alignment Length:	228	Identity:	115/228 - (50%)
Similarity:	153/228 - (67%)	Gaps:	6/228 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WTPLESNPEVLTKYIHKLGVSPAWSVTDVIGLEDDTLEWIPRPVKAFILLFPCSETYEKHRAEEH 68
            |.|||:||||..:::.:||:.|.|...||.|:|.:.|..|||||.|.:||||.:|.||..|.||.
Mouse     6 WLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMESELLSIIPRPVCAVLLLFPITEKYEVFRTEEE 70

  Fly    69 DRIKEVEEQHPEDLFYMRQFTHNAC---GTVALIHSVANNKE-VDIDRG-VLKDFLEKTASLSPE 128
            ::||...:.....:::|:|...|||   ||:.|||::||||: |..:.| .||.|||::.|:|||
Mouse    71 EKIKSQGQDVTSSVYFMKQTISNACGTIGTIGLIHAIANNKDKVHFESGSTLKKFLEESVSMSPE 135

  Fly   129 ERGRALEKDEKFTADHEALAQEGQTNAAN-HEKVIHHFIALVNKEGTLYELDGRKSFPIKHGPTS 192
            ||.:.||..:.....||..|.||||.|.: .|||..||||||:.:|.||||||.|.|||.||.||
Mouse   136 ERAKYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGWKPFPINHGKTS 200

  Fly   193 EETFVKDAAKVCKEFMARDPNEVRFTVLALTAA 225
            :||.::|..||||:||.|||:|:||..:||:||
Mouse   201 DETLLEDVIKVCKKFMERDPDELRFNAIALSAA 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uch	NP_001188681.1	Peptidase_C12_UCH_L1_L3	4..222	CDD:187737	111/223 (50%)
Uchl4	NP_291085.1	Peptidase_C12_UCH_L1_L3	6..230	CDD:187737	111/223 (50%)
		Interaction with ubiquitin. /evidence=ECO:0000250	8..13		3/4 (75%)
		Interaction with ubiquitin. /evidence=ECO:0000250	222..227		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2849
eggNOG	1	0.900	-	-		E1_KOG1415
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3443
Isobase	1	0.950	-	0	Normalized mean entropy	S1557
OMA	1	1.010	-	-		QHG53971
OrthoDB	1	1.010	-	-		D1013351at2759
OrthoFinder	1	1.000	-	-		FOG0001664
OrthoInspector	1	1.000	-	-		otm43659
orthoMCL	1	0.900	-	-		OOG6_101218
Panther	1	1.100	-	-	O	PTHR10589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1588
SonicParanoid	1	1.000	-	-		X1061
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820