DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uch and ubh-1

DIOPT Version :9

Sequence 1:	NP_001188681.1	Gene:	Uch / 33397	FlyBaseID:	FBgn0010288	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_504654.1	Gene:	ubh-1 / 179039	WormBaseID:	WBGene00006721	Length:	216	Species:	Caenorhabditis elegans

Alignment Length:	223	Identity:	85/223 - (38%)
Similarity:	123/223 - (55%)	Gaps:	18/223 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WTPLESNPEVLTKYIHKLGVSPAWSVTDVIGLEDDTLEWIPRPVKAFILLFPCSETYEKHRAEEH 68
            ||||||||.|:...|.|:|||...:| ||:..:|::   |.:|..|.||.||   .|:|    ..
Worm     5 WTPLESNPSVINPMIEKMGVSGVKTV-DVLFFDDES---IGKPQHAVILCFP---EYKK----VD 58

  Fly    69 DRIKEVEEQ---HPEDLFYMRQFTHNACGTVALIHSVANNKE-VDIDRGVLKDFLEKTASLSPEE 129
            :.:|.:.||   ..:.:|:|:|...|||||.||.||:||.:: :::..|....:|.:...:..||
Worm    59 EIMKPIYEQAKAADDSVFFMKQKISNACGTFALFHSLANLEDRINLGDGSFAKWLAEAKKVGIEE 123

  Fly   130 RGRALEKDEKFTADHEALAQEGQTNAANHEKVIHHFIALVNKEGTLYELDGRKSFPIKHGPTSEE 194
            |...|..:.:....|.|.|.:|||  |....|.||||..|.|.|.|||:|.|:.|..:.||||:.
Worm   124 RSDFLANNAELAGIHAAAATDGQT--APSGDVEHHFICFVGKNGILYEIDSRRPFAREIGPTSDA 186

  Fly   195 TFVKDAAKVCKEFMARDPNEVRFTVLAL 222
            |.||||...|:..:.:..| |.|:.:|:
Worm   187 TLVKDAGAACQHLIEKLDN-VSFSAIAV 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uch	NP_001188681.1	Peptidase_C12_UCH_L1_L3	4..222	CDD:187737	84/221 (38%)
ubh-1	NP_504654.1	Peptidase_C12_UCH_L1_L3	5..212	CDD:187737	84/220 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156492
Domainoid	1	1.000	136	1.000	Domainoid score	I3054
eggNOG	1	0.900	-	-		E1_KOG1415
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I3093
Isobase	1	0.950	-	0	Normalized mean entropy	S1557
OMA	1	1.010	-	-		QHG53971
OrthoDB	1	1.010	-	-		D1013351at2759
OrthoFinder	1	1.000	-	-		FOG0001664
OrthoInspector	1	1.000	-	-		otm14163
orthoMCL	1	0.900	-	-		OOG6_101218
Panther	1	1.100	-	-	LDO	PTHR10589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1588
SonicParanoid	1	1.000	-	-		X1061
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750