DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31668 and SLC5A6

DIOPT Version :9

Sequence 1:	NP_001097055.2	Gene:	CG31668 / 33395	FlyBaseID:	FBgn0051668	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_066918.2	Gene:	SLC5A6 / 8884	HGNCID:	11041	Length:	635	Species:	Homo sapiens

Alignment Length:	584	Identity:	196/584 - (33%)
Similarity:	306/584 - (52%)	Gaps:	47/584 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FGTVDYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMNDYMMGSRNL 70
            |..:||.||:.:.:||:|||||...                      :.:|...:.:.:|..|.:
Human    24 FSIMDYVVFVLLLVLSLAIGLYHAC----------------------RGWGRHTVGELLMADRKM 66

  Fly    71 RVFPVGMSLIASCISAVAIIGTPSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSALQVTSSYE 135
            ...||.:||:|:..|||||:|.|||||.:||||.|:.....|..|..::|::|||..|.:||:||
Human    67 GCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYE 131

  Fly   136 YLEMRFHSAIRSIVSIIFILDVVLYLPFLAYLPALALNQVSGMNMYLIEAFIIVICVIYTVLGGL 200
            |||:||:..:|...::.||..:|:|:..:.|.|:||||.|:|.:::|....:.::|.:||.||||
Human   132 YLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGL 196

  Fly   201 KAVVHTDIWQVVIMFASVLTIVVLATCYIDDQADFLEGLVRGGRLIFSETNPSPFARHTVWSVVI 265
            |||:.||::|.::||...|.::::.:..:...........:.||:...|.:|.||.|||.|::..
Human   197 KAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAF 261

  Fly   266 GNTFYWTSLNAVHQTVVHRYMSLPTLKMARASIAFLVVGAAFFISLLCYLGLLIFHAYRDCDPLS 330
            |..|...||..|:|..|.||:|..|.|.|..|...:.......:.:.|.:||::|..|::. |:|
Human   262 GGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMFAYYQEY-PMS 325

  Fly   331 AGLIM-NDDQLVPLFVVNSLGHVYGMPGLFIAGIFGASLSSLSVYLNSTSLVILQDLVRGCFKME 394
            ..... ..||.|..||::.|..:.|:||||||.:|..|||::|...||.:.|.::||:|..|. |
Human   326 IQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFP-E 389

  Fly   395 LGEWASTIVVKGSIVVLGLLAFAMVFVLEKVSGVLSISVSLAAIAASSTFGIFTVGMLVPWANTV 459
            ..|..:.::.:|.....|||...|.::..::..||..::|:..:......|:|.:||..|.||..
Human   390 FSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPP 454

  Fly   460 GTAVGGIASVLLTGWISFGSQFAAASGQLGSQRLPVSVEGCLANASVAENAWVAE-EEVFPL--- 520
            |..||.:|.:::..||..||...:    :||...|....|  ::.|:..|..||. ..:.||
Human   455 GAVVGLLAGLVMAFWIGIGSIVTS----MGSSMPPSPSNG--SSFSLPTNLTVATVTTLMPLTTF 513

  Fly   521 ---------YRLSYHWISPIGVLTVVVVGSLVSLVTKPTDIKSLDSDLITPVIHR---FLPKEC 572
                     |.|||.|.|.....||:|||.:|||:|.....:||:...|.||:.:   .||..|
Human   514 SKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSC 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	178/535 (33%)
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	187/555 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6739
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.770