DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31668 and slc5a5

DIOPT Version :9

Sequence 1:	NP_001097055.2	Gene:	CG31668 / 33395	FlyBaseID:	FBgn0051668	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001082860.1	Gene:	slc5a5 / 561445	ZFINID:	ZDB-GENE-060503-585	Length:	601	Species:	Danio rerio

Alignment Length:	609	Identity:	190/609 - (31%)
Similarity:	300/609 - (49%)	Gaps:	59/609 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTYR---FGTVDYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMND 62
            ||:.|   |..||||||..:..:|:.||| |..:||        ||            |..|::.
Zfish     3 MDSDRPPGFCLVDYAVFAAMLGVSVGIGL-FQSLRK--------TP------------GRSKVDS 46

  Fly    63 YMMGSRNLRVFPVGMSLIASCISAVAIIGTPSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSA 127
            :..|.|.....|||:||.||.:|||.::|.|||.|.||.::.::.:...|..|..:.:::|||..
Zfish    47 FFTGGRGFSAVPVGLSLCASFMSAVQVLGVPSETYLYGFKFLYMCLGQGLNSLMTAVLFVPVFYR 111

  Fly   128 LQVTSSYEYLEMRFHSAIRSIVSIIFILDVVLYLPFLAYLPALALNQVSGMNMYLIEAFIIVICV 192
            |::|||.:||.|||...::.:.|:.||:..:||...:.:.||:.|||.:|:||:.......:||.
Zfish   112 LKITSSSQYLGMRFGRGMQLLGSLQFIVATLLYTGIVIFAPAVILNQATGLNMWASLFSTGLICT 176

  Fly   193 IYTVLGGLKAVVHTDIWQVVIMFASVLTIVVLATCYIDDQADFLEGLVRGGRLIFSETNPSPFAR 257
            .||.:||:|||:.||::|:|:|.:..:.:.:..|......|..||....|.|:.|::....|..|
Zfish   177 FYTTVGGMKAVIWTDVFQIVVMLSGFIAVFIQGTILAGGPARVLEIANNGSRINFNDFAIDPQRR 241

  Fly   258 HTVWSVVIGNTFYWTSLNAVHQTVVHRYMSLPTLKMARASIAFLVVGAAFFISLLCYLGLLIFHA 322
            ::.||..:|.|..|.|:...:|..|.||:|..|.|.|:.::....||....:|.....|:::|..
Zfish   242 YSFWSFTVGGTMVWLSMYGANQAQVQRYISCRTEKQAQLALLVNQVGLCLIVSSAATCGIVMFAL 306

  Fly   323 YRDCDPLSAGLIMNDDQLVPLFVVNSLGHVYGMPGLFIAGIFGASLSSLSVYLNSTSLVILQDLV 387
            |.:||||..|.|...||.:|..|::...:..|.||||:|..:..:||::|..:|:.:.|.::|::
Zfish   307 YSNCDPLKIGRISAPDQYMPYLVLDIFRNHPGFPGLFLACAYSGTLSTVSTSINAMAAVTMEDVM 371

  Fly   388 RGCFKMELGEWASTIVVKGSIVV---------LGLLAFAMVFVLEKVSGVLSISVSLAAIAASST 443
            :        .|..||..:..:::         ||.:..|.:..|.. .|||..|.::..:.....
Zfish   372 K--------PWLITISQRKQLMLSRALSLFYGLGCITMAALSSLLD-WGVLQGSFTVMGVVNGPL 427

  Fly   444 FGIFTVGMLVPWANTVGTAVGGIASVLLTGWISFGSQFAAASGQLGSQRLPVSVEGCL-ANASVA 507
            .|.|.:||.||..|..|...|......|:.|::.||.....|.|:... ||.|...|| .||::.
Zfish   428 LGAFALGMFVPATNKPGVFSGVAVGFCLSLWLAVGSTIYPPSPQIMGV-LPTSAGQCLTTNATLN 491

  Fly   508 ENAWVAEEEVFPL-------YRLSYHWISPIGVLTVVVVGSLVSLVTKPTDIKSLDSDLITPVIH 565
            ..|.|....| ||       |.:||.:...:....||:||.:||.:|.||     ..|.|:|.:.
Zfish   492 TTASVLASSV-PLDYSFQNIYSISYLYFGALSTSAVVLVGVVVSYITGPT-----KKDSISPGLL 550

  Fly   566 RF--LPKECFEQGNAEENSVKDNP 587
            |:  ..|.|....:....::..||
Zfish   551 RWNLEQKPCDASCHILNETITLNP 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	169/538 (31%)
slc5a5	NP_001082860.1	SLC5-6-like_sbd	14..549	CDD:320982	181/571 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950