DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31668 and Slc5a6

DIOPT Version :9

Sequence 1:	NP_001097055.2	Gene:	CG31668 / 33395	FlyBaseID:	FBgn0051668	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_570102.1	Gene:	Slc5a6 / 170551	RGDID:	69648	Length:	634	Species:	Rattus norvegicus

Alignment Length:	594	Identity:	195/594 - (32%)
Similarity:	303/594 - (51%)	Gaps:	56/594 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DTYR----FGTVDYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMND 62
            ||.|    |..|||.||..:.:||:.||||...                      :.:|...:.:
  Rat    15 DTNRVISTFSVVDYVVFGLLLVLSLVIGLYHAC----------------------RGWGRHTVGE 57

  Fly    63 YMMGSRNLRVFPVGMSLIASCISAVAIIGTPSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSA 127
            .:|..|.:...||.:||:|:..|||||:|.|:|||.:||||.|:..:..|..|..::|::|||..
  Rat    58 LLMADRKMGCLPVALSLLATFQSAVAILGGPAEIYRFGTQYWFLGCSYFLGLLIPAHIFIPVFYR 122

  Fly   128 LQVTSSYEYLEMRFHSAIRSIVSIIFILDVVLYLPFLAYLPALALNQVSGMNMYLIEAFIIVICV 192
            |.:||:|||||:||:.|:|...::.||..:|:|:....|.|:||||.|:|.:::|....:.::|.
  Rat   123 LHLTSAYEYLELRFNKAVRICGTVTFIFQMVVYMGVALYAPSLALNAVTGFDLWLSVLALGIVCN 187

  Fly   193 IYTVLGGLKAVVHTDIWQVVIMFASVLTIVVLATCYIDDQADF-----LEGLVRGGRLIFSETNP 252
            |||.|||||||:.||::|.:|||...|.::::....:......     ..||:.|     .|.:|
  Rat   188 IYTALGGLKAVIWTDVFQTLIMFLGQLVVIIVGAAKVGGLGHVWAVASQHGLISG-----IELDP 247

  Fly   253 SPFARHTVWSVVIGNTFYWTSLNAVHQTVVHRYMSLPTLKMARASIAFLVVGAAFFISLLCYLGL 317
            .||.|||.|::..|..|...||..|:|..|.||:|..:.|.|..|...:.......:.:.|.:||
  Rat   248 DPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSHSEKAAVLSCYAVFPCQQVALCMSCLIGL 312

  Fly   318 LIFHAYRDCDPLSAGLIMNDDQLVPLFVVNSLGHVYGMPGLFIAGIFGASLSSLSVYLNSTSLVI 382
            ::|..|:.............||||..||::.|..:.|:||||:|.:|..|||::|...||.:.|.
  Rat   313 VMFAYYKKYSMSPQQEQAAPDQLVLYFVMDLLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVT 377

  Fly   383 LQDLVRGCFKMELGEWASTIVVKGSIVVLGLLAFAMVFVLEKVSGVLSISVSLAAIAASSTFGIF 447
            ::||::..|. :|.|..:.::.:......||:...|.:|...:..||..::|:..:......|:|
  Rat   378 MEDLIQPWFP-QLTETRAIMLSRSLAFAYGLVCLGMAYVSSHLGSVLQAALSIFGMVGGPLLGLF 441

  Fly   448 TVGMLVPWANTVGTAVGGIASVLLTGWISFGS-----QFAAASGQL-GS-----QRLPVSVEGCL 501
            .:||..|.||.:|..||.:..:.:..||..||     ..||||..| ||     ..|.|:....|
  Rat   442 CLGMFFPCANPLGAIVGLLTGLTMAFWIGIGSIVSRMSSAAASPPLNGSSSFLPSNLTVATVTTL 506

  Fly   502 ANASVAENAWVAEEEVFPLYRLSYHWISPIGVLTVVVVGSLVSLVTKPTDIKSLDSDLITPVIHR 566
            ..:::::...:.:     .|.|||.|.|.....||:.||.:|||:|.....:||:...|.||:.:
  Rat   507 MPSTLSKPTGLQQ-----FYSLSYLWYSAHNSTTVIAVGLIVSLLTGGMRGRSLNPGTIYPVLPK 566

  Fly   567 ---FLPKEC 572
               .||..|
  Rat   567 LLALLPLSC 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	175/537 (33%)
Slc5a6	NP_570102.1	SLC5-6-like_sbd	23..548	CDD:382020	183/557 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I11950
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920