DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31668 and SLC5A10

DIOPT Version :9

Sequence 1:	NP_001097055.2	Gene:	CG31668 / 33395	FlyBaseID:	FBgn0051668	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_016879680.2	Gene:	SLC5A10 / 125206	HGNCID:	23155	Length:	649	Species:	Homo sapiens

Alignment Length:	697	Identity:	150/697 - (21%)
Similarity:	259/697 - (37%)	Gaps:	200/697 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DTYRFGT-VDYAVFLGVTI---LSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMND 62
            |.:..|| :..|..:.:|:   |::|:|:: ...|.|||                      .:|.
Human     8 DLHTPGTQLSVADIIVITVYFALNVAVGIW-SSCRASRN----------------------TVNG 49

  Fly    63 YMMGSRNLRVFPVGMSLIASCISAVAIIGTPSE-------IYNYGTQYCFIVIALVLQGLAVSYI 120
            |.:..|::..:|:|.||.||...:...||....       :..:.....::::||       :::
Human    50 YFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLAL-------AWV 107

  Fly   121 YLPVFSALQVTSSYEYLEMRF-HSAIRSIVSII-FILDVVLYLPFLAYLPALALNQVSGMNMYLI 183
            ::|::.:.::.:..||::.|: ...||..:|:: .:|.|...:....|..||.::...|.|.||.
Human   108 FVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLS 172

  Fly   184 EAFIIVICVIYTVLGGLKAVVHTDIWQVVIMF--ASVLTI------------------------V 222
            ....:.|..:||:.|||.||::||..|.:||.  |.:|||                        :
Human   173 TILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIGGYGQLEAAYAQAIPSRTI 237

  Fly   223 VLATCYIDDQADFLEGLVRGGRLIFSE--TNPSPFARHTVWSVVIGNTFYWTSLNAVHQTVVHRY 285
            ...||:: .:.|.:.        :|.:  |...|:...| :.:.|..|:||    ...|.:|.|.
Human   238 ANTTCHL-PRTDAMH--------MFRDPHTGDLPWTGMT-FGLTIMATWYW----CTDQVIVQRS 288

  Fly   286 MSLPTLKMARASIAFLVVGAAFFISLLCYLGLLIF------------HAYRDCDPLSAGLIMNDD 338
            :|...|..|:|....     |.::.:| .:||:|.            |.|.:...:|.....:..
Human   289 LSARDLNHAKAGSIL-----ASYLKML-PMGLIIMPGMISRALFPGAHVYEERHQVSVSRTDDVG 347

  Fly   339 QLVPLFVVNSLGHVYG-------------MP----GLFIAGIFGASLSSLSVYLNSTSLVILQDL 386
            .:||...:.:.|...|             ||    ||.||.:..|.:|||:...||:|.:...|:
Human   348 CVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDI 412

  Fly   387 VRGCFKMELGEWASTIVVKGSI-----------------------VVLGLLAFAMVFVLEKVSGV 428
            .|. .:...||....:|.:..|                       .:|||:...:..|:..:.||
Human   413 WRR-LRPRSGERELLLVGRTGIPSTPPAPQSRLSFLLPETPPLERYLLGLVVMDLWLVIVALIGV 476

  Fly   429 LSISVSLAAIAASSTFG-------------------IFTVGMLVPWANTVGTAVGGIASVLLTGW 474
               ||:...:...|..|                   :|.:|:....||..| |..|:.:.|:.|.
Human   477 ---SVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQG-AFWGLIAGLVVGA 537

  Fly   475 ISFGSQFAAASGQLGSQRLPVSVEGCLANASVAENAWVAEEEVFPLYRLSYHWISPIGVLTVVVV 539
            .....:|...:...|......:|.|.:.....|    ||      |:.||.         .|||.
Human   538 TRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFA----VA------LFALSG---------AVVVA 583

  Fly   540 GSLVSLVTKPTDIKSLD--------------SDLITPVIHRFLPKEC 572
            |||::...:...|::|.              .|..||..|.|..:.|
Human   584 GSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVC 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	133/632 (21%)
SLC5A10	XP_016879680.2	SLC5-6-like_sbd	17..649	CDD:320982	147/688 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750