Protein Alignment CG31668 and SLC5A11

DIOPT Version :10

• Sequence 1: NP_001097055.2
• Gene: CG31668 / 33395
• FlyBaseID: FBgn0051668
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_001339171.1
• Gene: SLC5A11 / 115584
• HGNCID: 23091
• Length: 675
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 145/629 - (23%)
• Similarity: 233/629 - (37%)
• Gaps: 162/629 - (25%)

  Fly    10 DYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMNDYMMGSRNLRVFP 74
            |.||.:...:..:|:||:        :..||...|               :..|.:...::..:|
Human    28 DIAVLVLYFLFVLAVGLW--------STVKTKRDT---------------VKGYFLAGGDMVWWP 69

  Fly    75 VGMSLIASCISAVAIIGTPSEIYNYGTQYCFIVIALVLQG----LAVSYIYLPVFSALQVTSSYE 135
            ||.||.||.:.:...||    :...|......|.|..|.|    |.:::|:||::.|.|||:..|
Human    70 VGASLFASNVGSGHFIG----LAGSGAATGISVSAYELNGLFSVLMLAWIFLPIYIAGQVTTMPE 130

  Fly   136 YLEMRFHSAIRSIVSIIFILDVVLYLPFL---------AYLPALALNQVSGMNMYLIEAFIIVIC 191
            ||..|| ..||     |.|:..|||| |:         .|..|:.:.|...:::||....::.|.
Human   131 YLRKRF-GGIR-----IPIILAVLYL-FIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAIT 188

  Fly   192 VIYTVLGGLKAVVHTDIWQVVIMFASVLTIVVLATCYIDDQADFLE----------------GLV 240
            .:|||.|||.||::||..|.:||....||::..:...:.......|                ||.
Human   189 AVYTVAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSENSSCGLP 253

  Fly   241 RGGRL-IFSETNPSPFARHTVWSVV-----IGNTFYWTSLNAVHQTVVHRYMSLPTLKMARAS-- 297
            |.... ||.:    |......|..|     |.:.:||    ...|.:|.|.::...|..|:..
Human   254 REDAFHIFRD----PLTSDLPWPGVLFGMSIPSLWYW----CTDQVIVQRTLAAKNLSHAKGGAL 310

  Fly   298 -IAFLVVGAAFFISLLCYLGLLIFHAYRDC-DPLSAGLIMND-----DQLVPLFVVNSLGHVYGM 355
             .|:|.|...|.:.....:..::|.....| ||.....|.::     |...|..|:..|  ..|:
Human   311 MAAYLKVLPLFIMVFPGMVSRILFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELL--PTGL 373

  Fly   356 PGLFIAGIFGASLSSLSVYLNSTSLVILQDLVRGCFKMELGEW--------ASTIVVKGSIVVLG 412
            .||.:|.:..|.:|||:...||.|.:...||           |        ...:::.|.:.||.
Human   374 RGLMMAVMVAALMSSLTSIFNSASTIFTMDL-----------WNHLRPRASEKELMIVGRVFVLL 427

  Fly   413 LLAFAMVFV--------------LEKVSGVLSISVSLAAIAASSTFGIFTVGMLVPWANTVGTAV 463
            |:..:::::              ::.:|..|...|::          :|.:|......|..| |.
Human   428 LVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAV----------VFIMGCFWKRTNEKG-AF 481

  Fly   464 GGIASVLLTGWISFGSQFAAASGQLGS-QRLPVSVEGCLANASVAENAWVAEEEVFPLYRLSYHW 527
            .|:.|.||.|.:.....|.....:... ...||.|:.                       :.|.:
Human   482 WGLISGLLLGLVRLVLDFIYVQPRCDQPDERPVLVKS-----------------------IHYLY 523

  Fly   528 ISPIGVLTVVVVGSLVSLVTKPTDIKSLDSDLI-----TPVIHR 566
            .|.|.....::..|.||..|:|.. |.:.|.|.     .||:.:
Human   524 FSMILSTVTLITVSTVSWFTEPPS-KEMVSHLTWFTRHDPVVQK 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	134/587 (23%)
SLC5A11	NP_001339171.1	SLC5sbd_SGLT6	28..675	CDD:271381	145/629 (23%)