DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31668 and slc5a2

DIOPT Version :9

Sequence 1:	NP_001097055.2	Gene:	CG31668 / 33395	FlyBaseID:	FBgn0051668	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_002940641.3	Gene:	slc5a2 / 100380144	XenbaseID:	XB-GENE-5961970	Length:	617	Species:	Xenopus tropicalis

Alignment Length:	621	Identity:	137/621 - (22%)
Similarity:	244/621 - (39%)	Gaps:	117/621 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMNDYMMGSRNLRVFP 74
            |.:|.:|..|:.|.:||:                     ..|..|.|:  :..|.:..|::...|
Frog    26 DISVIVGYFIIIIGVGLW---------------------SMRRANRGT--VGGYFLAGRSMSWGP 67

  Fly    75 VGMSLIASCISA---VAIIGT--PSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSALQVTSSY 134
            ||.||.||.|.:   |.:.||  .|.|...|.::..:.:.|.|     .:|::||:...:|.:..
Frog    68 VGASLFASNIGSGHFVGLAGTGAASGIAVAGFEWNALFVVLFL-----GWIFVPVYLTAEVVTMP 127

  Fly   135 EYLEMRFHSAIRSIVSIIFILDVVLYLPFL-----AYLPALALNQVSGMNMYLIEAFIIVICVIY 194
            |||:.||..  :.|...:..|.:|:|: |.     .:..|:.:....|.|:||....::||..||
Frog   128 EYLKKRFGG--QRIQMYLSALSLVMYI-FTKISVDMFSGAVFIQVALGWNIYLSVIALLVITTIY 189

  Fly   195 TVLGGLKAVVHTDIWQVVIMFASVLTIVVLATCYIDDQADFLEGLVRGGRLIFSETNPS------ 253
            ||.|||.|:::||..|..::......:.|.|...:......:|..:.....:....:.|
Frog   190 TVTGGLAALMYTDTVQTFVIIGGACVLSVYAFNEVGGYDALMEKYMTAVPTVLGNVSESCAVPRA 254

  Fly   254 --------PFARHTVW-SVVIG----NTFYWTSLNAVHQTVVHRYM---SLPTLKMARASIAFLV 302
                    |.:....| ::::|    :|:||.|    .|.:|.|.:   |:..:|:......::.
Frog   255 DSLHLLRDPISGDLPWPALILGLTIVSTWYWCS----DQVIVQRCLAARSITHVKLGCVLCGYMK 315

  Fly   303 VGAAFFISLLCYLGLLIFHAYRDCDPLSAGLIMNDDQL------VPLFVVNSLGHVYGMPGLFIA 361
            :...|.:.:...:..::|.....|...|..|.....::      .|..|:..:.:  |:.||.:|
Frog   316 ILPMFLMVMPGMISRVLFTEDVACVEPSRCLAACGTKIGCSNIAYPKLVIELMPN--GLRGLMLA 378

  Fly   362 GIFGASLSSLSVYLNSTSLVILQDLVRGCFKMELGEWASTIVVKGSI--VVLGLLAFAMVFVLEK 424
            .:..|.:|||:...||:..:...|:.|   :|........:::.|.:  |.|..|:.|.:.|::.
Frog   379 VMLAALMSSLASIFNSSGTLFTMDVWR---RMRPRAEEKELLLVGRVWTVCLVALSIAWIPVVQA 440

  Fly   425 VSG--VLSISVSLAAIAASSTFGIFTVGMLVPWANTVGTAVGGIASVLLTGWISFGSQFAAASGQ 487
            ..|  :.....|:|:..|.....::.:.:.|...|..| |..|:...|..|......:|...||
Frog   441 AQGGQLFDYIQSVASFLAPPIAAVYFLALFVKRVNEPG-AFWGLVGGLFLGLCRMVPEFIFGSG- 503

  Fly   488 LGSQRLPVSVEGCLANASVAENAWVAEEEVFPLYRLSYHWISPIGVLTVVVVGS---LVSLVTKP 549
                       .|.|.:|.            |......|::. ..::..:..|:   :|||.|.|
Frog   504 -----------SCSAPSSC------------PTIICGVHYLY-FAIILFLCSGAIVLIVSLCTPP 544

  Fly   550 TDIKSLDSDLITPVIHRFLPKECFEQGNAEENSVKD 585
            ...|.|.. |:..:.|...|:|     ..||..|.|
Frog   545 IPEKKLHR-LVYSLRHSQEPRE-----EMEETGVSD 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	121/562 (22%)
slc5a2	XP_002940641.3	SLC5-6-like_sbd	25..617	CDD:382020	137/621 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010