DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31668 and slc5a8

DIOPT Version :9

Sequence 1:	NP_001097055.2	Gene:	CG31668 / 33395	FlyBaseID:	FBgn0051668	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_021331097.1	Gene:	slc5a8 / 100329285	ZFINID:	ZDB-GENE-141211-63	Length:	609	Species:	Danio rerio

Alignment Length:	582	Identity:	175/582 - (30%)
Similarity:	287/582 - (49%)	Gaps:	98/582 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTYRFGTVDYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMNDYMM 65
            |.:..|...||.||:.:..:|..||:|:.|..:|::...                      |:::
Zfish     3 MSSAVFSVWDYVVFIMMLAVSTGIGVYYAFAARSQSSSA----------------------DFLV 45

  Fly    66 GSRNLRVFPVGMSLIASCISAVAIIGTPSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSALQV 130
            ..|:|...||.:||.||.:||:.::|||.|:|.||..:..|..|........|.|:||||..|.|
Zfish    46 AGRSLSAPPVALSLTASFMSAITVLGTPVEVYKYGAIFILICFAYAFMVALSSEIFLPVFYRLGV 110

  Fly   131 TSSYEYLEMRFHSAIRSIVSIIFILDVVLYLPFLAYLPALALNQVSGMNMYLIEAFIIVICVIYT 195
            ||:||                      |||...:.|.||||||||:|::::.......|:|.:|.
Zfish   111 TSTYE----------------------VLYTGLVIYAPALALNQVTGVDLWGAVISTGVVCTLYC 153

  Fly   196 VLGGLKAVVHTDIWQVVIMFASVLTIVVLATCYIDDQADFLEGLV--------RGGRLIFSETNP 252
            .||||||||.||::||.||.|.:|.::|        |:..|:|.:        .|||:...:.:|
Zfish   154 TLGGLKAVVWTDVFQVGIMLAGLLAVIV--------QSVLLQGGIPRIISDSAHGGRINLWDFDP 210

  Fly   253 SPFARHTVWSVVIGNTFYWTSLNAVHQTVVHRYMSLPTLKMARAS--IAFLVVGAAFFISLLCYL 315
            :|..|||.||:.:|.||||||...::...|.||:|..:|..|:.:  |..:.:....|.::.|
Zfish   211 NPLRRHTFWSITVGGTFYWTSFYGINHAQVQRYISCKSLIHAKMALFINLVTLWVVTFCAVFC-- 273

  Fly   316 GLLIFHAYRDCDPLSAGLIMNDDQLVPLFVVNSLGHVYGMPGLFIAGIFGASL-----SSLSVYL 375
            ||.::..|::|||..|..:...|||:|..|::.|....|:||||:|..:..:.     |::|..:
Zfish   274 GLCLYSVYKNCDPWMAKKVSAQDQLMPYLVLDILSEFPGLPGLFVAAAYSGTFMFIVNSTVSSSV 338

  Fly   376 NSTSLVILQDLVRGCFKMELGE----WASTIVVKGSIVVLGLLAFAMVFVLEKVSGVLSISVSLA 436
            |:.:.|.:.|::|.  .:.|.|    |||    |...:..|.:...|..:...:.|:|..:.|::
Zfish   339 NALAAVTVTDVLRP--YLSLSEKQLSWAS----KAMSLFYGAVCIGMAGIASMMGGMLQAAFSIS 397

  Fly   437 AIAASSTFGIFTVGMLVPWANTVGTAVGGIASVLLTGWISFGSQFAAASGQLGSQRLPVSVEGCL 501
            .:......|:|::.:|.|.||:.|...|.::.:.|:.|:..|:|......: .|:.|.::..||
Zfish   398 GVIGGPLLGLFSLAILFPCANSKGGLAGLVSGLGLSLWVCIGAQIYPPPAE-NSRPLTLNTHGC- 460

  Fly   502 ANASVAENA--WVAEEEVF---------PL-----YRLSYHWISPIGVLTVVVVGSLVSLVT 547
             |.|:|.:.  |.|..:::         ||     |.|||.:...:|.:|.:.||.:||:::
Zfish   461 -NLSMAPDTTNWTASMDIYRIEEETLERPLLADNWYSLSYLYFGLLGTVTAIAVGLIVSILS 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	167/556 (30%)
slc5a8	XP_021331097.1	SLC5-6-like_sbd	6..527	CDD:320982	174/579 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.950