DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aop and elf2a

DIOPT Version :9

Sequence 1:	NP_001259908.1	Gene:	aop / 33392	FlyBaseID:	FBgn0000097	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001004116.1	Gene:	elf2a / 445489	ZFINID:	ZDB-GENE-040822-41	Length:	514	Species:	Danio rerio

Alignment Length:	523	Identity:	130/523 - (24%)
Similarity:	195/523 - (37%)	Gaps:	149/523 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 TGSNGSQPNIMPMKGISSASSNHSDSEEEYSETSGGVSKMPPAPLSYSTASPPGTPILKDIKPNW 299
            |....:|..:.|            |.||.|.|      |..||.:.....|       .|::..:
Zfish    18 TADEEAQQEVCP------------DGEESYGE------KDCPAVIVEQVNS-------ADVEQCY 57

  Fly   300 TQQL-----TNSF-VNSWSQQQ--QQQQQQQAAAVAAV------AAQAQQH-----QLQQQQQQQ 345
            ..|:     .|:: |...:::|  :.:.|:.||...:|      ||:|..|     .||..:..:
Zfish    58 AAQVLVYDDQNTYLVQDVAEEQVVETELQEMAAVEVSVHDKTIEAAEALLHMDSPASLQGDRSTE 122

  Fly   346 QLPQKLTLD---NTAGPV-----VTPAGGSIS-------APTTP--------SYMYKAKREFFPE 387
            :|..::.::   ...|||     |.....|:.       .|.||        ..:||.|    .:
Zfish   123 ELLSEVEVEVRTEDMGPVAKDIIVLQEADSLKKKKRAGRKPRTPRNCCDGSLDLVYKRK----SK 183

  Fly   388 NSEPNTNGRLLWDFLQQLLNDRN--QKYSDLIAWKCRDTGVFKIVDPAGLAKLWGIQKNHLSMNY 450
            :|:.:|.  .||:||..||.|:.  .||   |.|..::.|:||:||...::||||..||...|||
Zfish   184 DSKGSTT--YLWEFLLDLLQDKETCPKY---IKWTQKEKGIFKLVDSKAVSKLWGRHKNKPDMNY 243

  Fly   451 DKMSRALRYYYRVNILRKVQGERHCYQFLRNPTELKNI------KNISLLRQSTPANGNGGSPSM 509
            :.|.|||||||:..||.||:|:|..|||...|.::..|      .:|...::.|||..|..:|
Zfish   244 ETMGRALRYYYQRGILSKVEGQRLVYQFKEMPKDIVFIDDDNMDDSIEEGKRETPAASNRSNP-- 306

  Fly   510 PQGSSQAPGSPAGQNWNP--------QQQSQQQQQSPQRPASRNGPMSLPAVAAVAAAAAAAYGP 566
                 :..|||:  |..|        |......|||....::..|.:.|.....|......
Zfish   307 -----RGKGSPS--NAVPKIINLTSGQDAFMTVQQSGDSISAAPGTVRLAMQVPVLMTTQG---- 360

  Fly   567 PPTSPLFMHAINGAFHYLSAAAAGPPPNSPALNTPSAVGGPDK-----FQFHPLKLENGSGSGSE 626
            ...|.:.|::              |...||.|..|:::.|.:.     .|..|..:.....||..
Zfish   361 QKISTVTMNS--------------PTVRSPILPAPNSISGGNSAGKVLLQAVPTLVPAQGQSGER 411

  Fly   627 ----------SAGEDLKPTDLSVSSKSTA-TSNEDCYPLIRNADGLTTIKLIRYNEHQVAASPAG 680
                      ..|:...|..||..|..|. |||.....|...:..:||              ||.
Zfish   412 ITLQLITLPTMPGKPGTPITLSALSPLTVPTSNTQVLKLAIPSSIITT--------------PAS 462

  Fly   681 QSP 683
            .:|
Zfish   463 TAP 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aop	NP_001259908.1	SAM_PNT-Tel_Yan	49..116	CDD:176085
aop	NP_001259908.1	ETS	395..482	CDD:197710	42/88 (48%)
elf2a	NP_001004116.1	Elf-1_N	4..112	CDD:289109	25/118 (21%)
elf2a	NP_001004116.1	Ets	192..271	CDD:278602	40/81 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3804
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810