DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aop and ETV3L

DIOPT Version :9

Sequence 1:	NP_001259908.1	Gene:	aop / 33392	FlyBaseID:	FBgn0000097	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001004341.1	Gene:	ETV3L / 440695	HGNCID:	33834	Length:	361	Species:	Homo sapiens

Alignment Length:	323	Identity:	93/323 - (28%)
Similarity:	133/323 - (41%)	Gaps:	67/323 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 PA--GGSISAPTTPSYMYKAKREFFPENSEPNTNGRLLWDFLQQLLNDRNQKYSDLIAWKCRDTG 425
            ||  |..||....|.:.|||:       |.|.:....||.|:.:||  :.:::..:|||:..:.|
Human    11 PANPGNWISGLAFPDWAYKAE-------SSPGSRQIQLWHFILELL--QKEEFRHVIAWQQGEYG 66

  Fly   426 VFKIVDPAGLAKLWGIQKNHLSMNYDKMSRALRYYYRVNILRKVQGERHCYQFLRNPTELKNIKN 490
            .|.|.||..:|:|||.:|....|||||:||||||||...||.|.:|:|..|:|  |.::| .:.|
Human    67 EFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKF--NFSKL-IVVN 128

  Fly   491 ISLLRQSTPANGN--GGSPSM------PQG---------------------SSQAPGSPAGQNWN 526
            ..|.....|.:.:  .|:|::      |.|                     ..|.|..|
Human   129 YPLWEVRAPPSPHLLLGAPALCRPALVPVGVQSELLHSMLFAHQAMVEQLTGQQTPRGP------ 187

  Fly   527 PQQQSQQQ--QQSPQRPASRNGPMSLPAVAAVAAA-----AAAAYGP--PPTSPLFMHAINGAF- 581
            |:....::  ..|..|..|..||..|.....:.:.     ..|::.|  ||..|.....::|.|
Human   188 PETSGDKKGSSSSVYRLGSAPGPCRLGLCCHLGSVQGELPGVASFTPPLPPPLPSNWTCLSGPFL 252

  Fly   582 HYLSAAAAGPPPNSPALNTPSAVGGPDKFQFHPLKLENGSGSGSESAGE-----DLKPTDLSV 639
            ..|.:....|....|.:..|.....|..:.|..|.|..|.|.|   |||     .|:|..|.|
Human   253 PPLPSEQQLPGAFKPDILLPGPRSLPGAWHFPGLPLLAGLGQG---AGERLWLLSLRPEGLEV 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aop	NP_001259908.1	SAM_PNT-Tel_Yan	49..116	CDD:176085
aop	NP_001259908.1	ETS	395..482	CDD:197710	38/86 (44%)
ETV3L	NP_001004341.1	ETS	38..124	CDD:197710	39/89 (44%)
ETV3L	NP_001004341.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..201		4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910