DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aop and Etv6

DIOPT Version :9

Sequence 1:	NP_001259908.1	Gene:	aop / 33392	FlyBaseID:	FBgn0000097	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_038963620.1	Gene:	Etv6 / 312777	RGDID:	1559537	Length:	464	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	130/482 - (26%)
Similarity:	207/482 - (42%)	Gaps:	116/482 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PAPSS-QLAELKTQLPPSLPSDPRLWSREDVLVFLRFCVREFDLPKLDFDLFQMNGKALCLLTRA 93
            |.|.: ::.|....||..|...|..|||:||..:|::...||.|..::.:.|:||||||.|||:.
  Rat    47 PVPRALRMEEDSIHLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIESNTFEMNGKALLLLTKE 111

  Fly    94 DFGHRCPGAGDVLHNVLQMLIIESHMMQWHLPNSPVTPTSRYPLSPHSHPPTPTWPPLNAPPE-- 156
            ||.:|.|.:||||:.:||      |:::...|        |...||..||..    .::..||
  Rat   112 DFRYRSPHSGDVLYELLQ------HILKQRKP--------RILFSPFFHPGN----SIHTKPEVL 158

  Fly   157 ------------NSPFHSSAHSLAGHH-------FMAPNS-VTLSPPPSVDSQASSPPQAPYQNG 201
                        .:| .:.|.||  ||       ...|.| :|.:..||.|.:...|.::|..|.
  Rat   159 LHQNHEEDNCVQRTP-RTPAESL--HHNPPTIELLHRPRSPITTNHRPSPDPEQQRPLRSPLDNM 220

  Fly   202 GATGAAPGSAGGSAPAAGGATNTSNPTSSSASSTGSNGSQPNIMPMKGISSASSNHSDSEEEYSE 266
            ....:....|.|  |......|.......|.|...:|...|         |:.||...|......
  Rat   221 IRRLSPAERAQG--PRLQQENNHQESYPLSVSPMENNHCPP---------SSESNPKPSSPWQES 274

  Fly   267 TSGGVSKMPPAPLSYSTASPPGTPILKDIKPNWTQQLTNSFVNSWSQQQQQQQQQQAAAVAAVAA 331
            |.  |.::.|:|:.:        |::  :.|..:.....|.::.....:
  Rat   275 TR--VIQLMPSPIMH--------PLI--LNPRHSVDFKQSRISEDGMHR---------------- 311

  Fly   332 QAQQHQLQQQQQQQQLPQKLTLDNTAGPVVTPAGGSISAPTTPSYMYKAKREFFPENSEP---NT 393
            :.:...|..::....:...:.              |:|.|              .|::.|   ..
  Rat   312 EGKPINLSHREDLAYMNHIMV--------------SVSPP--------------EEHAMPIGRIA 348

  Fly   394 NGRLLWDFLQQLLNDRNQKYSDLIAWKCRDTGVFKIVDPAGLAKLWGIQKNHLSMNYDKMSRALR 458
            :.|||||::.|||:|  .:|.:.|.|:.:::.:|:||||.|||:|||..||..:|.|:|||||||
  Rat   349 DCRLLWDYVYQLLSD--SRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALR 411

  Fly   459 YYYRVNILRKVQGERHCYQFLRNPTEL 485
            :||::||:||..|:|..::|::.|.|:
  Rat   412 HYYKLNIIRKEPGQRLLFRFMKTPDEI 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aop	NP_001259908.1	SAM_PNT-Tel_Yan	49..116	CDD:176085	30/66 (45%)
aop	NP_001259908.1	ETS	395..482	CDD:197710	43/86 (50%)
Etv6	XP_038963620.1	SAM_PNT-Tel_Yan	67..134	CDD:176085	31/72 (43%)
Etv6	XP_038963620.1	ETS	350..436	CDD:197710	43/87 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7236
eggNOG	1	0.900	-	-		E1_KOG3804
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	178	1.000	Inparanoid score	I3924
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D357152at33208
OrthoFinder	1	1.000	-	-		FOG0005558
OrthoInspector	1	1.000	-	-		oto97114
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11849
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5189
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	11.020