DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aop and etv4

DIOPT Version :9

Sequence 1:	NP_001259908.1	Gene:	aop / 33392	FlyBaseID:	FBgn0000097	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_009304861.1	Gene:	etv4 / 30700	ZFINID:	ZDB-GENE-990415-71	Length:	495	Species:	Danio rerio

Alignment Length:	469	Identity:	119/469 - (25%)
Similarity:	167/469 - (35%)	Gaps:	121/469 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 TW-PPLNAPPENSPFHSSAHSLAGHHFMAPNSVTL-SPPPSVDSQASSPPQAP-----------Y 198
            || .....|..:..|....||        .|||.. |||..:..:..||...|           |
Zfish    61 TWLTEAQVPDSDEQFVPDFHS--------ENSVAFHSPPVKIKKEPQSPGSDPSQSCSHKQSFSY 117

  Fly   199 QNG---------GATGAAPGSAGGSAPAAGGA-------------------TNTSNPTSSSASST 235
            .||         ....||...||||..:..|.                   :...||.|:|.
Zfish   118 PNGEQCLYASAYEQKRAAVAGAGGSKSSCPGTPMSPMQHYSPKPTVGTRQESGYMNPPSASQ--- 179

  Fly   236 GSNGSQPNIMPMKGISSASSNHSDSEEEYSETSGGVSKMPPAPLS-------YSTASPPGTPILK 293
             |:....:..||...|...|..::....::.....:.:|.||..|       :...|.|..|.
Zfish   180 -SHACHSHSYPMNPSSRFPSGSAEMCPPFASQGQALQRMHPAHASGGGGGGYHRQHSDPCLPY-- 241

  Fly   294 DIKPNWTQQLTNSFVNSWSQQQQQQQQQQAAAVAAVAAQAQQHQLQQQQQQQQLPQKLTLDNTAG 358
                               ..||..:|:....:...||.....|.|:......:.::...|.|..
Zfish   242 -------------------PPQQTFKQEYMDPLYDRAAHINGPQPQRFPPAHMMVKQEPTDYTYE 287

  Fly   359 PVVTPA---------GGSISAPTTPSYMYKAKREFFPENSEPNT----------------NGRL- 397
            |...|.         |.|.....:..||::......||..|...                .|.|
Zfish   288 PADVPGCPSMYHHNEGYSNPQHNSEGYMFENDSRVVPEKFEGEVKQEGGSVFREGAPYQRRGSLQ 352

  Fly   398 LWDFLQQLLNDRNQKYSDLIAWKCRDTGV-FKIVDPAGLAKLWGIQKNHLSMNYDKMSRALRYYY 461
            ||.||..||:|.:..:  .|||..|  |: ||:::|..:|:|||:|||..:|||||:||:|||||
Zfish   353 LWQFLVALLDDPSNAH--FIAWTGR--GMEFKLIEPEEVARLWGMQKNRPAMNYDKLSRSLRYYY 413

  Fly   462 RVNILRKVQGERHCYQFLRNPTELKNIKNISLLRQSTPA------NGNGGSP--SMPQGSSQAPG 518
            ...|::||.|||:.|:|:..|..|.::......|.|..|      |.....|  .:.:|.|..|
Zfish   414 EKGIMQKVAGERYVYKFVCEPEALISLAFPDNQRPSLKAEFERYVNEEDTVPLSHLDEGVSYPP- 477

  Fly   519 SPAGQNWNPQQQSQ 532
            .||..|..||..|:
Zfish   478 EPAATNMGPQPYSK 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aop	NP_001259908.1	SAM_PNT-Tel_Yan	49..116	CDD:176085
aop	NP_001259908.1	ETS	395..482	CDD:197710	44/88 (50%)
etv4	XP_009304861.1	ETS_PEA3_N	5..349	CDD:282476	59/320 (18%)
etv4	XP_009304861.1	ETS	350..434	CDD:197710	43/87 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910