DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aop and EHF

DIOPT Version :9

Sequence 1:	NP_001259908.1	Gene:	aop / 33392	FlyBaseID:	FBgn0000097	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001193545.1	Gene:	EHF / 26298	HGNCID:	3246	Length:	322	Species:	Homo sapiens

Alignment Length:	274	Identity:	70/274 - (25%)
Similarity:	112/274 - (40%)	Gaps:	76/274 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 SNGSQPNIMPMKGISSASSNH--SDSEEEYSETSGGVSKMPPAPLSYSTASPPGTPILKDIKPNW 299
            :|....|.:|.:.. ..:..|  |.|.:|::..:|...:     |.||.        |:.:|.|.
Human    87 TNQLDANCIPFQEF-DINGEHLCSMSLQEFTRAAGTAGQ-----LLYSN--------LQHLKWNG 137

  Fly   300 ----------------TQQLTNSFVNSWSQQQQQQQQQQAAAVAAVAAQAQQHQLQQQQQQQQLP 348
                            |:|...|.:|:|..:.........:.|..:.::
Human   138 QCSSDLFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTVDLLDSK---------------- 186

  Fly   349 QKLTLDNTAGPVVTPAGGSISAPTTPSYMYKAKREFFPENSEP---------NTNGRLLWDFLQQ 404
                         |.....||. ||.|::..|:.....:..:|         |..|..||:|::.
Human   187 -------------TFCRAQISM-TTTSHLPVAESPDMKKEQDPPAKCHTKKHNPRGTHLWEFIRD 237

  Fly   405 -LLN-DRNQKYSDLIAWKCRDTGVFKIVDPAGLAKLWGIQKNHLSMNYDKMSRALRYYYRVNILR 467
             ||| |:|   ..||.|:.|..|||:.:....:|:|||.:||:.||.|:|:|||:||||:..||.
Human   238 ILLNPDKN---PGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILE 299

  Fly   468 KVQGERHCYQFLRN 481
            :|.|.|..|:|.:|
Human   300 RVDGRRLVYKFGKN 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aop	NP_001259908.1	SAM_PNT-Tel_Yan	49..116	CDD:176085
aop	NP_001259908.1	ETS	395..482	CDD:197710	41/89 (46%)
EHF	NP_001193545.1	SAM_PNT-ESE-3-like	61..138	CDD:188882	14/64 (22%)
EHF	NP_001193545.1	ETS	228..315	CDD:197710	41/89 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3804
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810