DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aop and etv7

DIOPT Version :9

Sequence 1:	NP_001259908.1	Gene:	aop / 33392	FlyBaseID:	FBgn0000097	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001076493.1	Gene:	etv7 / 100009655	ZFINID:	ZDB-GENE-070209-53	Length:	391	Species:	Danio rerio

Alignment Length:	554	Identity:	134/554 - (24%)
Similarity:	209/554 - (37%)	Gaps:	192/554 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MLPVQLSLNSLNPGIWSDVL---WRCPPAPSSQLAELKTQLPPSLPSDPRLWSREDVLVFLRFCV 67
            ::.:|...|...|.:.|..|   ...|.:.|..:.|...:||..|..:|.||::|||.::||:..
Zfish    10 LIKLQHGCNGNKPSVCSPTLPDPQNEPSSVSEAVPEELCKLPGRLRINPSLWNKEDVNLWLRWAQ 74

  Fly    68 REFDLPKLDFDLFQMNGKALCLLTRADFGHRCPGAGDVLHNVLQMLIIESHMMQWHLPNSPVTPT 132
            ||:.|.:.|...|:||||||||||:.||..|||.:||||:.:||      |:.|...
Zfish    75 REYSLRRADHQGFEMNGKALCLLTKEDFRLRCPSSGDVLYELLQ------HVKQQRR-------- 125

  Fly   133 SRYPLSPHSHPPTPTWPPLNAPPENSPFHSSAHSLAGHHFMAPNSVTLSPPPSVDSQASSPPQAP 197
                            ..:.:|..:|....|..:..|.:..:..||.:.|
Zfish   126 ----------------CAIFSPSSSSGTQISHETTTGLYVPSNRSVPVCP--------------- 159

  Fly   198 YQNGGATGAAPGSAGGSAPAAGGATNTSNPTSSSASSTGSNGSQPNIMPMKGISSASSNH-SDSE 261
                                    .|.::...|:|.||.....:.::.       |...| .|.:
Zfish   160 ------------------------VNPNSRAVSAACSTAQMQDRTHLF-------ADPEHPQDMQ 193

  Fly   262 EEYSETSGGVSKMPPAPLSYSTASPPGTPILKDIKPNWTQQLTNSFVNSWSQQQQQQQQQQAAAV 326
            .|....|                       ||:..|                |....:.:||.||
Zfish   194 TEIFHHS-----------------------LKEKMP----------------QISPDKSRQAIAV 219

  Fly   327 AAVAAQAQQHQLQQQQQQQQLPQKLTLDNTAGPVVTPAGGSISAPTTPSYMYKAKREFFPENSEP 391
            .:.                  .:.|.|.|              .|..|:           :|::|
Zfish   220 FST------------------EEPLNLSN--------------KPERPA-----------KNTQP 241

  Fly   392 N-TNGR-----LLWDFLQQLLNDRNQKYSDLIAWKCRDTGVFKIVDPAGLAKLWGIQKNHLSMNY 450
            : ..||     ||||::.|||:|  .:|...|.|:..:..:|::|||.|||:|||..||..:|.|
Zfish   242 SEATGRIPDCKLLWDYVYQLLSD--SRYEAFIRWEDPNDMIFRVVDPNGLARLWGNHKNRANMTY 304

  Fly   451 DKMSRALRYYYRVNILRKVQGERHCYQFLRNPTELKNIKNISLLRQSTPANGNGGSPSMPQGSSQ 515
            :|||||||:||::||::|..|:|..::||:.|.|:              ..|......:|    :
Zfish   305 EKMSRALRHYYKLNIIKKETGQRLLFRFLKTPEEI--------------IQGRSDRAEVP----E 351

  Fly   516 APGSPAGQNWNPQQQSQQQQQSPQRPASRNGPMS 549
            :|.||.    :|..:.:..:.||....:...|.|
Zfish   352 SPDSPV----SPDYREEALEVSPASTPTTLSPSS 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aop	NP_001259908.1	SAM_PNT-Tel_Yan	49..116	CDD:176085	34/66 (52%)
aop	NP_001259908.1	ETS	395..482	CDD:197710	43/91 (47%)
etv7	NP_001076493.1	SAM_PNT-Tel_Yan	56..123	CDD:176085	35/72 (49%)
etv7	NP_001076493.1	ETS	251..336	CDD:197710	41/86 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8930
eggNOG	1	0.900	-	-		E1_KOG3804
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	181	1.000	Inparanoid score	I3975
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D357152at33208
OrthoFinder	1	1.000	-	-		FOG0005558
OrthoInspector	1	1.000	-	-		oto41466
orthoMCL	1	0.900	-	-		OOG6_110462
Panther	1	1.100	-	-	LDO	PTHR11849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4726
SonicParanoid	1	1.000	-	-		X5189
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860