| Sequence 1: | NP_722765.2 | Gene: | AIF / 33390 | FlyBaseID: | FBgn0031392 | Length: | 739 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_004199.1 | Gene: | AIFM1 / 9131 | HGNCID: | 8768 | Length: | 613 | Species: | Homo sapiens |
| Alignment Length: | 584 | Identity: | 270/584 - (46%) |
|---|---|---|---|
| Similarity: | 366/584 - (62%) | Gaps: | 46/584 - (7%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 174 APGGGDGGDEECECRMKDLRLKCLLGALAALLAGGFLAWFMTRDTDDSEAKKAEAEEEERKRRLV 238
Fly 239 AGLATSPPS----------------SEDLPKHVPYLIIGGGTAAFSAFRAIKSNDATAKVLMISN 287
Fly 288 EFRKPYMRPPLSKELWYTPNPNEDPIKDYRFKQWTGSERSLFFEPDEFFIDPEDLDDNANGGIAV 352
Fly 353 AQGFSVKKVDAQKRIVTLNDGYEISYDECLIATGCAPKNLPMLRDAPPSVLEKVMVYRTPDDFDR 417
Fly 418 LRKLAAEKRSITIVGNGFIGSELACSLAHYSRENNGGKVYQVFQENANMSKVLPNYLSRWTTAKM 482
Fly 483 EAQGVCVIPNASIRSAVRDETNLKLELNNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSLGGF 547
Fly 548 VVNAELEARRNLYVAGDASCFFDPLLGRRRVEHHDHSVVSGRLAGENMTGAKKPYQHQSMFWSDL 612
Fly 613 GPEIGYEGIGLVDSSLPTVGVFALPSESATRVD---QLSESSDSDVPETSTSSSQSSKSDAGASQ 674
Fly 675 DGVTCDPDEAGNYGKGVIFYLKNDKIVGILLWNLFNRIGLARTIINQNKKYDDLNEVAKLFEIH 738 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| AIF | NP_722765.2 | Pyr_redox_2 | 257..573 | CDD:285266 | 148/315 (47%) |
| Pyr_redox | 427..512 | CDD:278498 | 40/84 (48%) | ||
| AIF_C | 591..720 | CDD:291391 | 72/131 (55%) | ||
| AIFM1 | NP_004199.1 | Mitochondrial localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z0X1 | 1..31 | ||
| AIF-MLS | 52..>133 | CDD:317386 | 19/97 (20%) | ||
| Mitochondrial localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z0X1 | 63..89 | 7/38 (18%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 100..127 | 3/26 (12%) | |||
| FAD-dependent oxidoreductase. /evidence=ECO:0000250 | 134..483 | 180/351 (51%) | |||
| Pyr_redox_2 | 150..462 | CDD:311792 | 150/314 (48%) | ||
| Nuclear localization signal. /evidence=ECO:0000255 | 446..451 | 3/4 (75%) | |||
| AIF_C | 465..593 | CDD:317164 | 72/131 (55%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 513..554 | 8/40 (20%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165147834 | |
| Domainoid | 1 | 1.000 | 294 | 1.000 | Domainoid score | I1503 |
| eggNOG | 1 | 0.900 | - | - | E1_COG0446 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H3100 | |
| Inparanoid | 1 | 1.050 | 502 | 1.000 | Inparanoid score | I1366 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S4416 |
| OMA | 1 | 1.010 | - | - | QHG55504 | |
| OrthoDB | 1 | 1.010 | - | - | D152327at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0005660 | |
| OrthoInspector | 1 | 1.000 | - | - | oto90894 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_104951 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR43557 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R4367 |
| SonicParanoid | 1 | 1.000 | - | - | X5322 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 17 | 16.750 | |||||