DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AIF and AIFM2

DIOPT Version :9

Sequence 1:	NP_722765.2	Gene:	AIF / 33390	FlyBaseID:	FBgn0031392	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001185625.1	Gene:	AIFM2 / 84883	HGNCID:	21411	Length:	373	Species:	Homo sapiens

Alignment Length:	333	Identity:	70/333 - (21%)
Similarity:	123/333 - (36%)	Gaps:	58/333 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 SPPSSEDLPKHVPYLIIGGGTAAFSAFRAIKSNDATAKVLMISNEFRKPYMRPPLSKELWYTPNP 308
            |..|.|....||  :|:|||....:|...:::             ...|:|...:.....:.
Human     3 SQVSVESGALHV--VIVGGGFGGIAAASQLQA-------------LNVPFMLVDMKDSFHHN--- 49

  Fly   309 NEDPIKDYRFKQWTGSERSLFFEPDEFFIDPEDLDDNANGGIAVAQGFSVKKVDAQKRIVTLNDG 373
                :...|....||..:..|......|      .||...|:.|.       :|.:.::|.|..|
Human    50 ----VAALRASVETGFAKKTFISYSVTF------KDNFRQGLVVG-------IDLKNQMVLLQGG 97

  Fly   374 YEISYDECLIATGCAPKNLPMLRDAPPSVLEKVMVYRTPDDFDRLRKLAAEKRSITIVGNGFIGS 438
            ..:.:...::||| :....|...:...|....:..|.     |.:|:: ...|.|.:||.|..|.
Human    98 EALPFSHLILATG-STGPFPGKFNEVSSQQAAIQAYE-----DMVRQV-QRSRFIVVVGGGSAGV 155

  Fly   439 ELACSLAHYSRENNGGKVYQVFQENANMSKVLPNYLSRWTTAKMEAQGVCVIPNASIRSAVRDET 503
            |:|   |....|....:|..:..:.|...|.|...:.:.....:..:||.::.:..:.:......
Human   156 EMA---AEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPL 217

  Fly   504 N-----LKLELNNGMTLMSDVVVVCVGCTPNTDL---AGPSRLEVDRSLGGFVVNAEL--EARRN 558
            |     :|::.:.|..:.:::|::|.|...|:..   |..|||   .|.|...||..|  |...|
Human   218 NEYREYIKVQTDKGTEVATNLVILCTGIKINSSAYRKAFESRL---ASSGALRVNEHLQVEGHSN 279

  Fly   559 LYVAGDAS 566
            :|..||.:
Human   280 VYAIGDCA 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AIF	NP_722765.2	Pyr_redox_2	257..573	CDD:285266	65/320 (20%)
		Pyr_redox	427..512	CDD:278498	17/89 (19%)
		AIF_C	591..720	CDD:291391
AIFM2	NP_001185625.1	NirB	39..356	CDD:330997	58/282 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810