DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AIF and Aifm1

DIOPT Version :9

Sequence 1:NP_722765.2 Gene:AIF / 33390 FlyBaseID:FBgn0031392 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_112646.1 Gene:Aifm1 / 83533 RGDID:620817 Length:612 Species:Rattus norvegicus


Alignment Length:584 Identity:268/584 - (45%)
Similarity:370/584 - (63%) Gaps:46/584 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 APGGGDGGDEECECRMKDLRLKCLLGALAALLAGGFLAWFMTRDTDDSEAKKAEAEEEERKRRLV 238
            |..|..||      :|.:..|..::| |:.:.||.:             |.|...|:::|....:
  Rat    54 ASSGPSGG------KMDNSVLVLIVG-LSTIGAGAY-------------AYKTIKEDQKRYNERI 98

  Fly   239 AGLATSPPSSE----------------DLPKHVPYLIIGGGTAAFSAFRAIKSNDATAKVLMISN 287
            .||..||...:                .:|.|||:|:||||||||:|.|:|::.|..|:||::|.
  Rat    99 MGLGLSPEEKQRRAIASAAEGGSVPPIRVPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSE 163

  Fly   288 EFRKPYMRPPLSKELWYTPNPNEDPIKDYRFKQWTGSERSLFFEPDEFFIDPEDLDDNANGGIAV 352
            :...||||||||||||::.:||  ..|..:|:||.|.|||::|:|..|::..:||....|||:||
  Rat   164 DPELPYMRPPLSKELWFSDDPN--VTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAV 226

  Fly   353 AQGFSVKKVDAQKRIVTLNDGYEISYDECLIATGCAPKNLPMLRDAPPSVLEKVMVYRTPDDFDR 417
            ..|..|..:|.:..:|.||||.:|::::||||||..|::|..:..|...|..:..::|...||..
  Rat   227 LTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRA 291

  Fly   418 LRKLAAEKRSITIVGNGFIGSELACSLAHYSRENNGGKVYQVFQENANMSKVLPNYLSRWTTAKM 482
            |.|::.|.:|||::|.||:||||||:|...| :.:|.:|.|:|.|..||.|:||.|||.||..|:
  Rat   292 LEKISREVKSITVIGGGFLGSELACALGRKS-QASGIEVIQLFPEKGNMGKILPEYLSNWTMEKV 355

  Fly   483 EAQGVCVIPNASIRSAVRDETNLKLELNNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSLGGF 547
            :.:||.|:|||.::|.......|.::|.:|..:.:|.:|..||..||.:||....||:|...|||
  Rat   356 KREGVKVMPNAIVQSVGVSGGKLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGF 420

  Fly   548 VVNAELEARRNLYVAGDASCFFDPLLGRRRVEHHDHSVVSGRLAGENMTGAKKPYQHQSMFWSDL 612
            .|||||:||.|::|||||:||:|..|||||||||||:||||||||||||||.|||.|||||||||
  Rat   421 RVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDL 485

  Fly   613 GPEIGYEGIGLVDSSLPTVGVFALPSESATRVD---QLSESSDSDVPETSTSSSQSSKSDAGASQ 674
            ||::|||.|||||||||||||||    .||..|   ..:|.|.:.:...|.:.|::|:.....|.
  Rat   486 GPDVGYEAIGLVDSSLPTVGVFA----KATAQDNPKSATEQSGTGIRSESETESEASEITIPPSD 546

  Fly   675 DGVTCDPDEAGNYGKGVIFYLKNDKIVGILLWNLFNRIGLARTIINQNKKYDDLNEVAKLFEIH 738
            ..|...|.|..:|||||||||::..:|||:|||:|||:.:||.||...::::|||||||||.||
  Rat   547 PAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIH 610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AIFNP_722765.2 Pyr_redox_2 257..573 CDD:285266 144/315 (46%)
Pyr_redox 427..512 CDD:278498 39/84 (46%)
AIF_C 591..720 CDD:291391 73/131 (56%)
Aifm1NP_112646.1 Mitochondrial localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z0X1 1..30
Mitochondrial localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z0X1 62..88 8/39 (21%)
FAD-dependent oxidoreductase. /evidence=ECO:0000250|UniProtKB:Q9Z0X1 133..482 176/351 (50%)
Pyr_redox_2 149..446 CDD:285266 133/299 (44%)
Pyr_redox 301..385 CDD:278498 39/84 (46%)
Nuclear localization signal. /evidence=ECO:0000255 445..450 3/4 (75%)
AIF_C 464..592 CDD:291391 73/131 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 512..551 8/38 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166341693
Domainoid 1 1.000 288 1.000 Domainoid score I1507
eggNOG 1 0.900 - - E1_COG0446
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3100
Inparanoid 1 1.050 499 1.000 Inparanoid score I1321
OMA 1 1.010 - - QHG55504
OrthoDB 1 1.010 - - D152327at33208
OrthoFinder 1 1.000 - - FOG0005660
OrthoInspector 1 1.000 - - oto97989
orthoMCL 1 0.900 - - OOG6_104951
Panther 1 1.100 - - LDO PTHR43557
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X5322
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

Return to query results.
Submit another query.