Protein Alignment AIF and Aifm3

DIOPT Version :9

• Sequence 1: NP_722765.2
• Gene: AIF / 33390
• FlyBaseID: FBgn0031392
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: XP_006522653.1
• Gene: Aifm3 / 72168
• MGIID: 1919418
• Length: 610
• Species: Mus musculus
• Alignment Length: 760
• Identity: 163/760 - (21%)
• Similarity: 250/760 - (32%)
• Gaps: 281/760 - (36%)

  Fly    73 CVTKPSTTPPVE-------------EYETAVEGAGVP-AYANAQFQAHSQSEPLFKVGFADVKSV 123
            |.:||.   |||             :.|.:..|.|.| .|.......|..:|
Mouse     4 CFSKPK---PVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAE------------- 52

  Fly   124 CSAKDVLKSDSAKLSTSQPVLDSCKATSP--CEEFKRKRKETTCQPCD-EDGTAPGGGDGGDEEC 185
                       .:|.|.||.      .||  |.|      .|.|...| |:|
Mouse    53 -----------ERLPTPQPY------PSPQDCVE------ATVCHVKDLENG------------- 81

  Fly   186 ECRMKDLRL---KCLL----GALAAL----------LAGGFLA-------W------FMTRDTDD 220
              :|:::.|   |.||    |...||          |..|.|:       |      ..|.|.:|
Mouse    82 --QMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNISTGDLED 144

  Fly   221 ----SEAKKAEAEEEERK--------------RRLVAGLATSPPSSEDLPKHVPYLIIGGGTAAF 267
                ....|.:.:.|:.|              |..|.....||.:......:|  ||:|.|.|..
Mouse   145 FPGLDSLHKFQVKIEKEKVTIRASKQALQLQRRTKVMAKCISPSAGHSSSTNV--LIVGAGAAGL 207

  Fly   268 SAFRAIKSNDATAKVLMISNEFRKPYMRPPLSKELWYTPNPNEDPIKDYRFKQWTGSERSLFFEP 332
            .....::....:.::::.:.:...||.|..|||.|...|                   ..|...|
Mouse   208 VCAETLRQEGFSDRIVLCTLDRHLPYDRAKLSKSLDAQP-------------------EQLALRP 253

  Fly   333 DEFFIDPEDLDDNANGGIAVAQGFSVKKVDAQKRIVTLNDGYEISYDECLIATGCAPKNLPML-R 396
            .|||         ...||.:.....|..||.:.:.|...||:::.|.:.|:|.|.:||.|... :
Mouse   254 KEFF---------RAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAPGSSPKTLTCKGK 309

  Fly   397 DAPPSVLEKVMVYRTPDDFDRLRKLAAEKRSITIVGNGFIGSELACSL---AH------------ 446
            |     :|.|...|||:|.:|:.:| |..|:..:||.||:|.|:|..|   ||
Mouse   310 D-----VENVFTIRTPEDANRVLRL-ARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPF 368

  Fly   447 --YSRENNGGKVYQVFQENANMSKVLPNYLSRWTTAKMEAQGVCVIPNASIRSAVRDETNLKLEL 509
              :..|..|..:.::|:.|.      ..:..:...:::.||      ...::..|         |
Mouse   369 RRFLGERVGRALMKMFENNR------VKFYMQTEVSELRAQ------EGKLQEVV---------L 412

  Fly   510 NNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSLGGFVVNAELEAR-RNLYVAGDASCFFDPLL 573
            .:...|.:||.|:.:|..|.|.....|.:.:| |.|...||..::.. ..::.||||..|  ||.
Mouse   413 KSSKVLRADVCVLGIGAVPATGFLRQSGIGLD-SRGFIPVNKMMQTNVPGVFAAGDAVTF--PLA 474

  Fly   574 GRR----RVEHHDHSVVSGRLAGENMTGAKK-----PYQHQSMFWSDLGPEIGYEGIGLVDSSLP 629
            .|.    .:.|...:...||:|.:||...:.     ||...:||    |..:.|.|.|
Mouse   475 WRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEINTVPYLWTAMF----GKSLRYAGYG------- 528

  Fly   630 TVGVFALPSESATRVDQLSESSDSDVPETSTSSSQSSKSDAGASQDGVTCDPDEAGNYGKGVIFY 694
                               |..|..:                     :..|.:|.    |.|.||
Mouse   529 -------------------EGFDDVI---------------------IQGDLEEL----KFVAFY 549

  Fly   695 LKNDKIVGILLWNLFNRIGLARTIINQNKKYDDLNEVAKLFEIHA 739
            .|:|:::.:...|                 ||.:  |:|:.|:.|
Mouse   550 TKSDEVIAVASMN-----------------YDPI--VSKVAEVLA 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AIF	NP_722765.2	Pyr_redox_2	257..573	CDD:285266	81/334 (24%)
		Pyr_redox	427..512	CDD:278498	18/101 (18%)
		AIF_C	591..720	CDD:291391	22/133 (17%)
Aifm3	XP_006522653.1	Rieske_AIFL_N	70..163	CDD:239560	22/107 (21%)
		Pyr_redox_2	198..493	CDD:369639	84/352 (24%)
		Reductase_C	512..>562	CDD:379686	17/104 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810