DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AIF and Aifm2

DIOPT Version :9

Sequence 1:NP_722765.2 Gene:AIF / 33390 FlyBaseID:FBgn0031392 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_722474.2 Gene:Aifm2 / 71361 MGIID:1918611 Length:380 Species:Mus musculus


Alignment Length:359 Identity:70/359 - (19%)
Similarity:131/359 - (36%) Gaps:69/359 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 HVPYLIIGGGTAAFSAFRAIKSNDATAKVLMISNEFRKPYMRPPLSKELWYTPNPNEDPIKDYRF 318
            ||  :|:|||....:|...:::             ...|:|...:.....:.       :...|.
Mouse    13 HV--VIVGGGFGGIAAASQLQA-------------LNVPFMLVDMKDSFHHN-------VAALRA 55

  Fly   319 KQWTGSERSLFFEPDEFFIDPEDLDDNANGGIAVAQGFSVKKVDAQKRIVTLNDGYEISYDECLI 383
            ...:|..:..|......|      .||...|..:.       :|.:.|:|.|..|..:.:...::
Mouse    56 SVESGFAKKTFISYSATF------KDNFRQGKVIG-------IDLKNRMVLLQGGEALPFSHLIL 107

  Fly   384 ATGCAPKNLPMLRDAP-PSVLEKVMVYRTP-DDFDRLRKLAAEKRSITIVGNGFIGSELACSLAH 446
            |||..         .| |....:|...:.. ..::.:.|.....:.|.:||.|..|.|:|   |.
Mouse   108 ATGST---------GPFPGKFNEVSCQQAAIQAYEDMVKQIQRSQFIVVVGGGSAGVEMA---AE 160

  Fly   447 YSRENNGGKVYQVFQENANMSKVLPNYLSRWTTAKMEAQGVCVIPN---ASIRSAVRDETN--LK 506
            ...|....:|..:........|.|...:.:.....:..:||.::.:   :::....|:|..  :|
Mouse   161 IKTEYPEKEVTLIHSRVPLADKELLPCVRQEVKEILLRKGVQLLLSERVSNLEELPRNEYREYIK 225

  Fly   507 LELNNGMTLMSDVVVVCVGCTPNTDL---AGPSRLEVDRSLGGFVVN--AELEARRNLYVAGDAS 566
            :|.:.|..:.:::|:||.|...|:..   |..|||   .|.|...||  .::|...|:|..||.:
Mouse   226 VETDKGTEVATNMVIVCNGIKINSSAYRSAFESRL---ASNGALKVNEFLQVEGYSNIYAIGDCA 287

  Fly   567 CFFDPLLGRRRVEHHDHSVVSGRLAGENMTGAKK 600
            ...:|.:..       |:.:...:|..|:..:.|
Mouse   288 DTKEPKMAY-------HAGLHANVAVANIVNSMK 314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AIFNP_722765.2 Pyr_redox_2 257..573 CDD:285266 64/327 (20%)
Pyr_redox 427..512 CDD:278498 18/89 (20%)
AIF_C 591..720 CDD:291391 3/10 (30%)
Aifm2NP_722474.2 Pyr_redox_2 20..302 CDD:285266 62/336 (18%)
TIM_phosphate_binding <268..364 CDD:304361 12/54 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0446
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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