DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AIF and aifm5

DIOPT Version :9

Sequence 1:	NP_722765.2	Gene:	AIF / 33390	FlyBaseID:	FBgn0031392	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_001920911.2	Gene:	aifm5 / 557064	ZFINID:	ZDB-GENE-091118-96	Length:	543	Species:	Danio rerio

Alignment Length:	393	Identity:	101/393 - (25%)
Similarity:	169/393 - (43%)	Gaps:	66/393 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 PKHVPY------------LIIGGGTAAFSAFRAIKSNDATAKVLMISNEFRKPYMRPPLSKELWY 304
            ||.|.:            :::|||.|.......::..:...:::|:|.:...||.:..|||.:
Zfish   125 PKRVKWMGVRDQSVSHTVMLLGGGAACLMCAETLRQENYGGRIIMVSRDDLLPYDKTRLSKVM-- 187

  Fly   305 TPNPNEDPIKDYRFKQWTGSERSLFFEPD-EFFIDPEDLDDNANGGIAVAQGFSVKKVDAQKRIV 368
              |...|.:...|.        ..|.:.| |.::..|.|                 .:|..|:.|
Zfish   188 --NAESDSLLMRRM--------DFFHKHDIEVWLKKEAL-----------------SIDTNKKTV 225

  Fly   369 TLNDGYEISYDECLIATGCAPKNLPMLRDAPPSVLEKVMVYRTPDDFDRLRKLAAEKRSITIVGN 433
            |.:||...|||:.||||||..|.|    |.|.:.||:|::..||:|...:.......|:: |||.
Zfish   226 TFDDGLIQSYDQILIATGCRAKGL----DCPGANLERVLMLETPEDARCVHYACTGCRTV-IVGT 285

  Fly   434 GFIGSELACSLAHYSRENNGGKVYQVFQENANMSKVLPNYLSRWTTAKMEAQGVCVIPNASIRSA 498
            .|||.|:|..|.     :....:..:........|.|...:.:.|...:|.:||....|.::...
Zfish   286 SFIGMEVAAYLL-----DTSSSMTVIGSSELPYQKTLGREIGKVTMTMLEEKGVTFYMNDAVAEV 345

  Fly   499 VRDETNLK-LELNNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSLGGFVVNAELEARRNL--- 559
            ......:| ::|.:|:|:.:|:::|.:|.:||::....||:.:|..  .:|:..|. .|.|:
Zfish   346 QGKNRRVKAVKLKSGITIEADLLIVAIGVSPNSEFLKGSRVRMDSK--NYVIVDEY-MRTNITDV 407

  Fly   560 YVAGDASCFFDPL---LGRR-RVEHHDHSVVSGRLAGENMTGAKKPYQHQSMFWSDL-GPEIGYE 619
            |.|||.:.|  ||   .|:: .:.|...:...||:|..||...:........:|:.| |..|.|.
Zfish   408 YCAGDLTSF--PLKMAKGQKVSLGHWQIAQAHGRIAALNMLCREVELNTVPYYWTVLFGRTIRYA 470

  Fly   620 GIG 622
            |.|
Zfish   471 GYG 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AIF	NP_722765.2	Pyr_redox_2	257..573	CDD:285266	84/335 (25%)
		Pyr_redox	427..512	CDD:278498	18/85 (21%)
		AIF_C	591..720	CDD:291391	10/33 (30%)
aifm5	XP_001920911.2	Rieske_AIFL_N	21..114	CDD:239560
		Pyr_redox_2	140..438	CDD:285266	86/341 (25%)
		Pyr_redox	279..360	CDD:278498	19/86 (22%)
		Reductase_C	457..535	CDD:291425	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810