DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AIF and aifm1

DIOPT Version :9

Sequence 1:	NP_722765.2	Gene:	AIF / 33390	FlyBaseID:	FBgn0031392	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_005165182.1	Gene:	aifm1 / 373125	ZFINID:	ZDB-GENE-030826-11	Length:	748	Species:	Danio rerio

Alignment Length:	774	Identity:	292/774 - (37%)
Similarity:	414/774 - (53%)	Gaps:	131/774 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GVRCL-------------TQRFIRQAYILANRRLLGPVPQRSPPAYAPLRPAHSSLYQMVKKRTL 56
            |..||             ::|:..:...:|:|:     .|.|.||.|....|.|....:.::.||
Zfish    64 GAACLGGGIYAYRTVSQDSERYNERMRQIASRQ-----SQESKPAKALAEVAESKEEPVAEEPTL 123

  Fly    57 EARTKLQANKYPNHQVCVTKPSTTPPVEEYETAVEGAGVPAYANAQFQAHSQSEPLFKVGFAD-V 120
                                  ..|.|||.....:....|..........|..||..::...: |
Zfish   124 ----------------------IEPAVEESPVTEDIVESPEAVAEPIVKSSIPEPAVEIAVTEPV 166

  Fly   121 KSVCSAKDVLKS----DSAKLSTSQPVLDSCKATSPCEEFKRKRKETTCQPCDEDGTAPGGGDGG 181
            ......:.|::|    ...:.|..:|::::....:..|..:..:.|....|..|....|
Zfish   167 VEASVPESVIESPLMEPVVEASVQEPIIEATATETVAEAPEVIQSEEPIAPVVESEPVP------ 225

  Fly   182 DEECECRMKDLRLKCLLGALAALLAGGFLAWFMTRDTDDSEAKKAEAEEEERKRRLVAGLATSP- 245
                                          ...|....::.:....|.|            |||
Zfish   226 ------------------------------VVSTEHVPEASSVSESAPE------------TSPA 248

  Fly   246 --PSSE---------DLPKHVPYLIIGGGTAAFSAFRAIKSNDATAKVLMISNEFRKPYMRPPLS 299
              |::|         |:.:|.|||:||||||:|:|.|:|::.|..|:||:|:.|...||||||||
Zfish   249 AAPAAEPIDPTAPHLDVLEHAPYLLIGGGTASFAAARSIRARDPGARVLIITEESDLPYMRPPLS 313

  Fly   300 KELWYTPNPNEDPIKDYRFKQWTGSERSLFFEPDEFFIDPEDLDDNANGGIAVAQGFSVKKVDAQ 364
            ||||::.:|.  ..:..|||||.|.|||::|:|..|::.|.||....|||:||.....|..:|.:
Zfish   314 KELWFSDDPK--VTESLRFKQWNGKERSIYFQPPSFYVSPADLAKVENGGVAVLTDSKVVHMDVR 376

  Fly   365 KRIVTLNDGYEISYDECLIATGCAPKNLPMLRDAPPSVLEKVMVYRTPDDFDRLRKLAAEKRSIT 429
            ...|.|:||.||||::||||||..|:||.::..|...|:::..::|..:||..|.|::.|.:|||
Zfish   377 GNKVKLSDGSEISYEKCLIATGGVPRNLQVIDRAGEEVIKRTTLFRKIEDFRSLEKISREVKSIT 441

  Fly   430 IVGNGFIGSELACSLAHYSRENNGGKVYQVFQENANMSKVLPNYLSRWTTAKMEAQGVCVIPNAS 494
            |:|.||:||||||:|...|.: .|.:|.|:|.|..||.||||.|||.|||.|:..:||.||.:|.
Zfish   442 IIGGGFLGSELACALGRRSAD-PGLEVMQLFPEKGNMGKVLPEYLSNWTTEKVRKEGVNVITDAV 505

  Fly   495 IRSAVRDETNLKLELNNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSLGGFVVNAELEARRNL 559
            :::.......|:::|.:|..:.:|.:|..||..|:.:||..:.||||...||:.|||||:||.|:
Zfish   506 VKNVTYKNDKLEIKLKDGRLVKTDHIVAAVGLEPSVELAKSAGLEVDSDFGGYRVNAELQARSNI 570

  Fly   560 YVAGDASCFFDPLLGRRRVEHHDHSVVSGRLAGENMTGAKKPYQHQSMFWSDLGPEIGYEGIGLV 624
            :|||||:||:|..|||||||||||:||||||||||||||.|||.|||||||||||::|||.||:|
Zfish   571 WVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGANKPYWHQSMFWSDLGPDVGYEAIGIV 635

  Fly   625 DSSLPTVGVFALPSESATRVDQLSESSDSDVPETSTSSSQS---SKSD----AGASQDG-VTCDP 681
            |||||||||||             :::..|.|:.:|..|.:   |:|:    ||..:.| ||..|
Zfish   636 DSSLPTVGVFA-------------KATAKDTPKAATEQSGTGIRSESETEAVAGVLEVGTVTPAP 687

  Fly   682 --DEAGNYGKGVIFYLKNDKIVGILLWNLFNRIGLARTIINQNKKYDDLNEVAKLFEIH 738
              .:..:||||:||||::..:|||:|||:|||:.:||.||...:.:.|||||||||.||
Zfish   688 PVQQKEDYGKGIIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGEAHTDLNEVAKLFNIH 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AIF	NP_722765.2	Pyr_redox_2	257..573	CDD:285266	148/315 (47%)
		Pyr_redox	427..512	CDD:278498	40/84 (48%)
		AIF_C	591..720	CDD:291391	71/138 (51%)
aifm1	XP_005165182.1	AIF-MLS	<56..203	CDD:291623	28/165 (17%)
		Pyr_redox_2	274..584	CDD:285266	146/312 (47%)
		Pyr_redox	439..523	CDD:278498	40/84 (48%)
		AIF_C	602..728	CDD:291391	71/138 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581704
Domainoid	1	1.000	293	1.000	Domainoid score	I1488
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3100
Inparanoid	1	1.050	484	1.000	Inparanoid score	I1403
OMA	1	1.010	-	-		QHG55504
OrthoDB	1	1.010	-	-		D152327at33208
OrthoFinder	1	1.000	-	-		FOG0005660
OrthoInspector	1	1.000	-	-		oto40245
orthoMCL	1	0.900	-	-		OOG6_104951
Panther	1	1.100	-	-	LDO	PTHR43557
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4367
SonicParanoid	1	1.000	-	-		X5322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800