DRSC/TRiP Functional Genomics Resources

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Protein Alignment AIF and Aifm1

DIOPT Version :10

Sequence 1:NP_722765.2 Gene:AIF / 33390 FlyBaseID:FBgn0031392 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_036149.1 Gene:Aifm1 / 26926 MGIID:1349419 Length:612 Species:Mus musculus


Alignment Length:584 Identity:269/584 - (46%)
Similarity:370/584 - (63%) Gaps:46/584 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 APGGGDGGDEECECRMKDLRLKCLLGALAALLAGGFLAWFMTRDTDDSEAKKAEAEEEERKRRLV 238
            |..|..||      :|.:..|..::| |:.:.||.:             |.|...|:::|....|
Mouse    54 ASSGSSGG------KMDNSVLVLIVG-LSTIGAGAY-------------AYKTIKEDQKRYNERV 98

  Fly   239 AGLATSPPSSE----------------DLPKHVPYLIIGGGTAAFSAFRAIKSNDATAKVLMISN 287
            .||..||...:                ..|.|||:|:||||||||:|.|:|::.|..|:||::|.
Mouse    99 MGLGLSPEEKQRRAIASATEGGSVPQIRAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSE 163

  Fly   288 EFRKPYMRPPLSKELWYTPNPNEDPIKDYRFKQWTGSERSLFFEPDEFFIDPEDLDDNANGGIAV 352
            :...||||||||||||::.:||  ..|..:|:||.|.|||::|:|..|::..:||.:..|||:||
Mouse   164 DPELPYMRPPLSKELWFSDDPN--VTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPNIENGGVAV 226

  Fly   353 AQGFSVKKVDAQKRIVTLNDGYEISYDECLIATGCAPKNLPMLRDAPPSVLEKVMVYRTPDDFDR 417
            ..|..|..:|.:..:|.||||.:|::::||||||..|::|..:..|...|..:..::|...||..
Mouse   227 LTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRA 291

  Fly   418 LRKLAAEKRSITIVGNGFIGSELACSLAHYSRENNGGKVYQVFQENANMSKVLPNYLSRWTTAKM 482
            |.|::.|.:|||::|.||:||||||:|...| :.:|.:|.|:|.|..||.|:||.|||.||..|:
Mouse   292 LEKISREVKSITVIGGGFLGSELACALGRKS-QASGIEVIQLFPEKGNMGKILPQYLSNWTMEKV 355

  Fly   483 EAQGVCVIPNASIRSAVRDETNLKLELNNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSLGGF 547
            :.:||.|:|||.::|.......|.::|.:|..:.:|.:|..||..||.:||....||:|...|||
Mouse   356 KREGVKVMPNAIVQSVGVSGGRLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGF 420

  Fly   548 VVNAELEARRNLYVAGDASCFFDPLLGRRRVEHHDHSVVSGRLAGENMTGAKKPYQHQSMFWSDL 612
            .|||||:||.|::|||||:||:|..|||||||||||:||||||||||||||.|||.|||||||||
Mouse   421 RVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDL 485

  Fly   613 GPEIGYEGIGLVDSSLPTVGVFALPSESATRVD---QLSESSDSDVPETSTSSSQSSKSDAGASQ 674
            ||::|||.|||||||||||||||    .||..|   ..:|.|.:.:...|.:.|::|:.....|.
Mouse   486 GPDVGYEAIGLVDSSLPTVGVFA----KATAQDNPKSATEQSGTGIRSESETESEASEITIPPSA 546

  Fly   675 DGVTCDPDEAGNYGKGVIFYLKNDKIVGILLWNLFNRIGLARTIINQNKKYDDLNEVAKLFEIH 738
            ..|...|.|..:|||||||||::..:|||:|||:|||:.:||.||...::::|||||||||.||
Mouse   547 PAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIH 610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AIFNP_722765.2 NirB 256..719 CDD:440863 234/465 (50%)
AIF_C 591..721 CDD:464279 74/132 (56%)
Aifm1NP_036149.1 Mitochondrial localization signal. /evidence=ECO:0000305|PubMed:9989411 1..30
AIF-MLS 51..>128 CDD:464407 19/93 (20%)
Mitochondrial localization signal. /evidence=ECO:0000305|PubMed:9989411 62..88 8/39 (21%)
FAD-dependent oxidoreductase 133..482 176/351 (50%)
NirB 147..595 CDD:440863 225/454 (50%)
Nuclear localization signal. /evidence=ECO:0000255 445..450 3/4 (75%)
AIF_C 464..593 CDD:464279 74/132 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 512..551 8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

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