DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AIF and aifm3

DIOPT Version :9

Sequence 1:	NP_722765.2	Gene:	AIF / 33390	FlyBaseID:	FBgn0031392	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001121885.1	Gene:	aifm3 / 100150876	-ID:	-	Length:	599	Species:	Danio rerio

Alignment Length:	760	Identity:	161/760 - (21%)
Similarity:	256/760 - (33%)	Gaps:	275/760 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 CVTKPSTTPPVE--------EYETAVEGAGVPAYANAQFQAHSQSEPLFKVGFADVKSVCSAKDV 129
            |::||.   |||        :.|..|:...    .|.:....|:..|...:|.      ||.:|.
Zfish     4 CLSKPK---PVEVKVELTLLDKEKEVDLMS----PNGKASPFSECRPNGSLGH------CSDEDS 55

  Fly   130 LKSDSAKLSTSQPVLDSCKATSPCEEFKRKRKETTCQPCDEDGTAPGGGDGGDEECECRMKDLR- 193
            :        |.:|              :||.::..                  |...|.:|||.
Zfish    56 M--------TLRP--------------QRKNRDYI------------------EASVCHIKDLEN 80

  Fly   194 ---LKCLLGALAALLA---GGFLA-------------------------W------FMTRDTDD- 220
               .:..|||..|||.   |.|.|                         |      ..|.|.:|
Zfish    81 GQMREVDLGAGRALLIKEHGEFFAMGHKCPHYGAPLVKGVLSKGHVRCPWHGACFNIATGDIEDF 145

  Fly   221 ------------SEAKKA------EAEEEERKRRLVAGLATSPPSSEDLPKHVPYLIIGGGTAAF 267
                        .|.:|.      :|.:.:|:.::::..:....||... .||  ||||.|.|..
Zfish   146 PGLDSLPTFQVRVEKEKVIIRANKQALQTQRRSKVMSKCSAVINSSTGF-SHV--LIIGSGPAGL 207

  Fly   268 SAFRAIKSNDATAKVLMISNEFRKPYMRPPLSKELWYTPNPNEDPIKDYRFKQWTGSERSLFFEP 332
            .....::....|.::::.:.:...||.||.|||.|                   ..:...|....
Zfish   208 VCAETLRQEGFTDRIVICTTDKHLPYDRPKLSKSL-------------------ESTAEQLQLRS 253

  Fly   333 DEFFIDPEDLDDNANGGIAVAQGFSVKKVDAQKRIVTLNDGYEISYDECLIATGCAPKNLPML-R 396
            .:||    .:.|     |.|.....|..||.:...||..||:::.|.:..||||..||.|... :
Zfish   254 SDFF----QMHD-----IEVLLEKEVVSVDVKTHTVTFRDGFKMEYRKLFIATGSRPKPLSYKGK 309

  Fly   397 DAPPSVLEKVMVYRTPDDFDRLRKLAAEKRSITIVGNGFIGSELACSLAHYSR------------ 449
            |     :..|...|||:|.:.:..||:.|.:: |:|..|||.|:|.:|...:.
Zfish   310 D-----VGNVFHLRTPEDANSIVTLASSKNAV-IIGTSFIGMEVAAALTDKAHSVSVIGIEAVPF 368

  Fly   450 -----ENNGGKVYQVFQENANMSKVLPNYLSRWTTAKMEAQGVCVIPNASIRSAVRDETNLKLEL 509
                 |..|..:.::|:.|.....:|...   |     |.:|    .|..::..|         |
Zfish   369 RKALGEKVGKALMKLFESNRVKFYMLNEV---W-----EMRG----HNGQLKEVV---------L 412

  Fly   510 NNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSLGGFV-VNAELEAR-RNLYVAGDASCFFDPL 572
            .:|..|.:||.|:.:|.:|.|.....|.:.:|..  ||: ||..::.. ..::..||...|  |
Zfish   413 KSGKVLRADVCVIGIGSSPATAFLKQSGVHIDSK--GFIPVNKTMQTNIDGVFAGGDVVTF--P- 472

  Fly   573 LGRR-----RVEHHDHSVVSGRLAGENMTGAKKPYQHQSMFWSDL-GPEIGYEGIGLVDSSLPTV 631
            ||.|     .:.|...:.|.||||...:.|.....:....||:.: |..|.|.|.|
Zfish   473 LGLRSNKKVNIPHWQMAHVHGRLAALGIMGKASDIKTVPYFWTAMFGKSIRYAGYG--------- 528

  Fly   632 GVFALPSESATRVDQLSESSDSDVPETSTSSSQSSKSDAGASQDG-----VTCDPDEAGNYGKGV 691
                                                       ||     :..|.||.    |.|
Zfish   529 -------------------------------------------DGFDDVVIQGDLDEL----KFV 546

  Fly   692 IFYLKNDKIVGILLWN---LFNRI----GLARTIINQNKKYDDLN 729
            .||.|::::|.:...|   :.:|:    |..:||..::.:..|::
Zfish   547 AFYTKSEEVVAVASMNYDPIVSRVAEVFGSGKTIRKRDVETGDMS 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AIF	NP_722765.2	Pyr_redox_2	257..573	CDD:285266	82/335 (24%)
		Pyr_redox	427..512	CDD:278498	19/101 (19%)
		AIF_C	591..720	CDD:291391	25/141 (18%)
aifm3	NP_001121885.1	Rieske_AIFL_N	70..164	CDD:239560	19/93 (20%)
		Pyr_redox_2	196..493	CDD:285266	89/358 (25%)
		NAD_binding_8	199..>218	CDD:290186	5/18 (28%)
		Pyr_redox	334..415	CDD:278498	19/102 (19%)
		Reductase_C	512..>562	CDD:291425	18/105 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810