DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPG2 and Dscam1

DIOPT Version :9

Sequence 1:	XP_011539620.1	Gene:	HSPG2 / 3339	HGNCID:	5273	Length:	4574	Species:	Homo sapiens
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	2440	Identity:	499/2440 - (20%)
Similarity:	779/2440 - (31%)	Gaps:	819/2440 - (33%)

- Green bases have known domain annotations that are detailed below.

Human  2425 GPI----PPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGS----LPARHQVRGSRLYI 2481
            ||:    |..||:.|:||.||     :.|..:|....::.|.:..|:    :|...|:......:
  Fly    38 GPVFLKEPTNRIDFSNSTGAE-----IECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLV 97

Human  2482 FQASPAD-------AGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQ 2539
            |....|:       |..|.|.|.|...:.|:        .::...|..:|....:...:.|..|.
  Fly    98 FPPFRAEDYRQEVHAQVYACLARNQFGSIIS--------RDVHVRAVVSQHYEEDIHKAFVIRGN 154

Human  2540 TLDLNCVVP---GQSHAQVTWHK-------------------RGGSLPVRHQTHGSLLRLYQASP 2582
            :..|.|.:|   ......::||.                   ..|.|.:|           :..|
  Fly   155 SAILKCDIPSFVADFVNVISWHSDEKENFYPGTEYDGKYLVLPSGELHIR-----------EVGP 208

Human  2583 ADS-GEYVCRV---LGSSVPLEASV--LVTIEPAGSV-PALG-------VTPTVRIESSSSQVAE 2633
            .|. ..|.||.   |.....|.|:.  ||..||.||| |.|.       :|.|        :|.:
  Fly   209 EDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVSPQLSGNGNQEHITLT--------RVPK 265

Human  2634 GQTLDLNCLVAGQAH----------AQVTWHKRGGSLPAR-HQVHGSRLRLLQVTPADSGEYVCR 2687
            ..::.|.|  ..||:          .:.|..|:...|..| .||.|: |.:......|||:|:|.
  Fly   266 MGSVTLMC--PAQAYPVPFFRWYKFIEGTTRKQAVVLNDRVKQVSGT-LIIKDAVVEDSGKYLCV 327

Human  2688 VVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYK 2752
            |..|.|.:....::|:...||          .:|:..:.::..|......|........|::|.|
  Fly   328 VNNSVGGESVETVLTVTAPLS----------AKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMK 382

Human  2753 RGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPP-IR 2816
            .|.::.....:    |||..|...|.|.|.|.|.|...|.|.|..:.:.|       ...|| ||
  Fly   383 DGKAIGHSEPV----LRIESVKKEDKGMYQCFVRNDQESAEASAELKLGG-------RFDPPVIR 436

Human  2817 IESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS--RHQ------THG---SHLRLHQMS 2870
            ......|:..|.::.|.||....|...|:|...|..:.:  |:|      .:|   |:|.:..:.
  Fly   437 QAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVH 501

Human  2871 VADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPG 2935
            ..|.|.|.|.|.:.:...|.|..::|           ..:|...:.....:..||||.:.|.|.|
  Fly   502 ANDGGLYKCIAKSKVGVAEHSAKLNV-----------YGLPYIRQMEKKAIVAGETLIVTCPVAG 555

Human  2936 QAHAQVTWHKRGGSLPSHHQTR---GSRLRLHHVS-PADSGEYVCRVMGSSGPLEASVLVTIEAS 2996
            .....:.|.:...:||.:.:.:   ...|.:.:|. .:|...|.|......|         ..|.
  Fly   556 YPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEG---------YSAR 611

Human  2997 GSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKC-VVPGQAHAQVTW-HKRGGNLPARHQVHGP 3059
            ||..|.|.......|...|   ..:..|.::||.| :..|....:|.| .:|........||. |
  Fly   612 GSLEVQVMVLPQIVPFAYE---DLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQ-P 672

Human  3060 LLRLNQV------------SPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYI 3112
            .:|.|::            |||.:|..:|..:..:||...||.:|:.      :|...:.:|
  Fly   673 QMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVN------VPPRWILEP--- 728

Human  3113 EASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQ--THGSQLR-----LHL--VSPAD 3168
              :.....:|....:.|...|....||||.|..|..|..::  .....:|     ||:  :...:
  Fly   729 --TDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTN 791

Human  3169 SGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAA 3233
            .|.|:|.|.:|.|....|...::|......:.:||         :.|.::|:.|..:|.. .|..
  Fly   792 EGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLR---------NQTARRGEPAVLQCEA-KGEK 846

Human  3234 PISLEWKTRNQELE---DNVH-----ISPNG--SIITIVGTRPSNHGTYRCVASNAYGVAQSVVN 3288
            ||.:.|...|..|:   ||.:     |...|  |.::|..|..|:...:.|||:||:|...:.:|
  Fly   847 PIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASIN 911

Human  3289 LSVHGPPTVSVLPEGPVWVKV----GKAVTLECVSAGEP---------------RSSARWTRISS 3334
            :      .|..:||.|..:||    |::|.|   |..:|               ||.|.|:.|..
  Fly   912 M------IVQEVPEMPYALKVLDKSGRSVQL---SWAQPYDGNSPLDRYIIEFKRSRASWSEIDR 967

Human  3335 TPAKLEQRTYGLMDSHAV-LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAP-GAPQV 3397
            .          ::..|.. .|:....|:.......:|:||:||:|....|.:.|...|| |.||
  Fly   968 V----------IVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQ- 1021

Human  3398 QAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYI-- 3460
                 .:.||..:..|:|  .|..|.|...|:             |:.|          |.|:
  Fly  1022 -----NIKVEPVNQTTMR--VTWKPPPRTEWN-------------GEIL----------GYYVGY 1056

Human  3461 --CNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLP 3523
              .|..|  .:...||....|..      .||       .::||.|...|     |:|.|
  Fly  1057 KLSNTNS--SYVFETINFITEEG------KEH-------NLELQNLRVYT-----QYSVV----- 1096

Human  3524 GRATARNELLHFERAAPEDSGRYRCRVTNKVGS---AEAFAQLLVQGPPGSLPA-TSIPAGSTPT 3584
                                    .:..||:|:   :|...|...:|.|...|: |:....::.|
  Fly  1097 ------------------------IQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQT 1137

Human  3585 VQ---VTPQLETKSIGASVEFHCAV--PSDRGTQLRWFKEGGQLPPGHSVQDGVLR--------- 3635
            ::   |:|.||  |....::.:..|  |||     .|:.|..:.....:..|.||.
  Fly  1138 IRVGWVSPPLE--SANGVIKTYKVVYAPSD-----EWYDETKRHYKKTASSDTVLHGLKKYTNYT 1195

Human  3636 IQNLDQSCQGTYI------CQAHGPWGKAQASAQLVIQALPSVLINIR----------------- 3677
            :|.|..:..|..:      ||......:|....:.::....::|::.|
  Fly  1196 MQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSK 1260

Human  3678 -----TSVQTVVVGH-AVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQY 3736
                 |..:|..|.| .:.||...|...||...|
  Fly  1261 AEGAETETKTQKVPHYQMSFEATELEKNKPYEFW------------------------------- 1294

Human  3737 RCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSA-------------AVFPCIASGYPTPD 3788
             .||:...|..|       |:...::||.: :|||..|             |..||:|.|.|.|:
  Fly  1295 -VTASTTIGEGQ-------QSKSIVAMPSD-QVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPE 1350

Human  3789 ISWSKLDG-SLPPDSR---LENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYF 3849
            |:| |:.| ....:.|   |.:..|::.||..||||.|.|.|.|...| .:..|    :.:|...
  Fly  1351 ITW-KIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAK-DSITH----KLIVLAP 1409

Human  3850 TQTPYSFLPLPTIKDA----------------------------YRKFEIKITFRPDSADGMLLY 3886
            .|:|:..|. .|..||                            :...|:.:..:..:.:|:|..
  Fly  1410 PQSPHVTLS-ATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCG 1473

Human  3887 NGQKRVPGSPTNL-ANRQPDFISFGLVGGRPEF----RFDAGSGMATIRH---------PTPLAL 3937
            :..:.......|: |....|.::....|.:|:.    ||...|..:...|         |    :
  Fly  1474 SRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCP----M 1534

Human  3938 GHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGC 4002
            .||...:..|...:.:.|..::.|.|     .:..|||
  Fly  1535 SHFVVESKKRDQIEWNQISNNVKPDN-----NYVVLDL--------------------------- 1567

Human  4003 VRELRIQGEEIVFHDLNLTAHGISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQ 4067
                    |...:::|.:|||.                              .||||.:..:.:.
  Fly  1568 --------EPATWYNLRITAHN------------------------------SAGFTVAEYDFAT 1594

Human  4068 ALHCHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVT----TPSLSGAGSYLALPALT 4128
                                                    :|||    .|...|:|.       .
  Fly  1595 ----------------------------------------LTVTGGTIAPLDDGSGH-------G 1612

Human  4129 NTHHELR--------LDVEFK-PLAPDGVLL------------------FSGGKSGPVEDFVSLA 4166
            |.|..:|        ||:.|. ||....|::                  ..||:.....|.|...
  Fly  1613 NVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQ 1677

Human  4167 MVG-------GHLEFRYELGSGLAVLRSAEPLALGRWHRVSAERLNKD-GSLRVNGGRPVLRSSP 4223
            .:|       ...:.|.|||......|...|:....::  :.:|:.:. |.||.|......|.:|
  Fly  1678 TMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYN--TCDRIKRGRGGLRSNHSTWDPRRNP 1740

Human  4224 GKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDS 4288
                  ||:..|    ..|.||:.     ..|:                          |..:.:
  Fly  1741 ------NLYEEL----KAPPVPMH-----GNHY--------------------------GHAHGN 1764

Human  4289 SPCE-RQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPG 4352
            :.|. |.|......|..|   .|..|   ||:.::           :|         |:.:....
  Fly  1765 AECHYRHPGMEDEICPYA---TFHLL---GFREEM-----------DP---------TKAMNFQT 1803

Human  4353 FSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEV 4417
            |.                 |..|..| ..||..|.....    ..||||.|||
  Fly  1804 FP-----------------HQNGHAG-PVPGHAGTMLPP----GHPGHVHSRS------------ 1834

Human  4418 RTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGS---GEARLVS-----EDPIN-- 4472
                                        |.|......|||..:   |::.:.:     :||.|
  Fly  1835 ----------------------------GSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCA 1871

Human  4473 -DGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAK--------GSVYIGGAPDVATLTG 4528
             :.::.|.|        .:...|..|.||  |||.....|.        ||.|.|.........|
  Fly  1872 EEDQYRRYT--------RVNSQGGSLYSG--PGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYG 1926

Human  4529 GRFSSG--ITGCVKNLVLHSARPGAPPPQPLDLQH 4561
            .|.|.|  ..|..:|....|..|..|||:..|:.:
  Fly  1927 SRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSN 1961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPG2	XP_011539620.1	SEA	80..193	CDD:214554
		LDLa	216..251	CDD:238060
		LDLa	302..336	CDD:238060
		LDLa	342..376	CDD:238060
		LDLa	385..420	CDD:238060
		IG	431..507	CDD:214652
		Ig_Perlecan_D2_like	438..515	CDD:143220
		LamB	608..734	CDD:214597
		EGF_Lam	782..824	CDD:238012
		EGF_Lam	831..888	CDD:238012
		Laminin_EGF	897..939	CDD:278482
		LamB	1003..1130	CDD:214597
		EGF_Lam	1176..1225	CDD:238012
		EGF_Lam	1227..1282	CDD:238012
		Laminin_EGF	1293..1340	CDD:278482
		LamB	1574..1699	CDD:214597
		EGF_Lam	1746..1794	CDD:238012
		Laminin_EGF	1796..1851	CDD:278482
		Ig_2	1866..1958	CDD:290606
		IG_like	1866..1946	CDD:214653
		Ig3_Perlecan_like	1954..2039	CDD:143231
		IG	1961..2040	CDD:214652
		I-set	2049..2133	CDD:254352
		Ig	2063..2133	CDD:299845
		I-set	2139..2225	CDD:254352
		IGc2	2153..2215	CDD:197706
		IG_like	2240..2317	CDD:214653
		IGc2	2247..2307	CDD:197706
		IG	2341..2418	CDD:214652
		IGc2	2348..2408	CDD:197706
		IG_like	2434..2508	CDD:214653	19/84 (23%)
		IGc2	2441..2500	CDD:197706	14/69 (20%)
		IG_like	2530..2607	CDD:214653	20/104 (19%)
		IGc2	2537..2595	CDD:197706	15/83 (18%)
		I-set	2620..2703	CDD:254352	22/93 (24%)
		IGc2	2633..2693	CDD:197706	19/70 (27%)
		IG	2731..2800	CDD:214652	19/68 (28%)
		IGc2	2731..2790	CDD:197706	16/58 (28%)
		IG_like	2819..2896	CDD:214653	21/87 (24%)
		IGc2	2826..2885	CDD:197706	18/69 (26%)
		IG	2916..2993	CDD:214652	16/80 (20%)
		IGc2	2923..2983	CDD:197706	15/63 (24%)
		IG	3016..3093	CDD:214652	22/90 (24%)
		IGc2	3023..3083	CDD:197706	18/73 (25%)
		Ig_2	3112..3192	CDD:290606	20/88 (23%)
		IG_like	3115..3192	CDD:214653	20/85 (24%)
		I-set	3205..3291	CDD:254352	25/95 (26%)
		ig	3209..3289	CDD:278476	24/89 (27%)
		IG	3303..3385	CDD:214652	23/101 (23%)
		Ig	3313..3382	CDD:143165	18/84 (21%)
		IG	3404..3478	CDD:214652	16/77 (21%)
		IGc2	3409..3468	CDD:197706	12/62 (19%)
		I-set	3482..3565	CDD:254352	14/85 (16%)
		IGc2	3496..3555	CDD:197706	9/58 (16%)
		IG_like	3589..3666	CDD:214653	19/93 (20%)
		Ig	3600..3666	CDD:299845	15/82 (18%)
		I-set	3676..3755	CDD:254352	15/101 (15%)
		IGc2	3686..3745	CDD:197706	9/59 (15%)
		I-set	3764..3841	CDD:254352	31/93 (33%)
		Ig	3779..3834	CDD:299845	23/58 (40%)
		LamG	3848..4008	CDD:238058	28/201 (14%)
		EGF_CA	<4035..4064	CDD:238011	4/28 (14%)
		LamG	4117..4266	CDD:238058	36/183 (20%)
		EGF	4291..4321	CDD:278437	9/30 (30%)
EGF_CA	4328..4359	CDD:238011	3/30 (10%)
LamG	4386..4545	CDD:238058	37/179 (21%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	24/104 (23%)
		IG	57..133	CDD:214652	16/88 (18%)
		IG_like	267..343	CDD:214653	20/78 (26%)
		Ig	269..340	CDD:143165	20/73 (27%)
		IG_like	353..425	CDD:214653	19/75 (25%)
		IGc2	361..413	CDD:197706	15/55 (27%)
		I-set	433..527	CDD:254352	24/93 (26%)
		IGc2	446..517	CDD:197706	18/70 (26%)
		I-set	533..618	CDD:254352	20/93 (22%)
		IGc2	544..607	CDD:197706	15/62 (24%)
		Ig	641..714	CDD:143165	18/73 (25%)
		IGc2	735..804	CDD:197706	18/68 (26%)
		I-set	819..914	CDD:254352	27/110 (25%)
		Ig	833..921	CDD:299845	27/94 (29%)
		FN3	918..1011	CDD:238020	25/105 (24%)
		FN3	1018..1116	CDD:238020	34/177 (19%)
		FN3	1124..1217	CDD:238020	21/99 (21%)
		FN3	1222..1312	CDD:238020	18/128 (14%)
		Ig	1339..1406	CDD:299845	25/72 (35%)
		FN3	1409..1499	CDD:238020	12/90 (13%)
		FN3	1504..1584	CDD:238020	20/153 (13%)
		Dscam_C	1890..2008	CDD:289151	22/74 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910