| Sequence 1: | XP_011539620.1 | Gene: | HSPG2 / 3339 | HGNCID: | 5273 | Length: | 4574 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_030109089.1 | Gene: | Hspg2 / 15530 | MGIID: | 96257 | Length: | 4398 | Species: | Mus musculus |
| Alignment Length: | 4577 | Identity: | 3795/4577 - (82%) |
|---|---|---|---|
| Similarity: | 4035/4577 - (88%) | Gaps: | 182/4577 - (3%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDMLADSIS 65
Human 66 GDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLESEYLKIPGDQ 130
Human 131 VVSVVFIKELDGWVFVELDVGSEGNADGAQIQEMLLRVISSGSVASYVTSPQGFQFRRLGTAQTP 195
Human 196 PPPPAAVAVAVTPVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISP 260
Human 261 TFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQE 325
Human 326 DCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQF 390
Human 391 RCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPII 455
Human 456 NWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRA 520
Human 521 GPCPDGHFYLEHSAACLPCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPGTPPLS 585
Human 586 STQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRYELARGMLEPVQR 650
Human 651 PDVVLMGAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTV 715
Human 716 YNTKMASVGLSDIAMDTTVTHATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCS 780
Human 781 GCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSD 845
Human 846 TCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEAC 910
Human 911 RCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTN 975
Human 976 AASTHTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPGST 1040
Human 1041 PLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMALAGIDTL 1105
Human 1106 LIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLY 1170
Human 1171 LGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAA 1235
Human 1236 GQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGS 1300
Human 1301 VSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTH 1365
Human 1366 FAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKGEAYF 1430
Human 1431 ARMRRAHQRTLPMALAPGLWEVLARLLPPFHQNRTSLSEEQLRAAVTAGRIPEPPEGRDWAQRAS 1495
Human 1496 QVDEAQRRMDAEIWQLLSSFAAQPQPPPQGLSPHPQPAAALRAAPPPSSSSSSSSSSASLSFSPG 1560
Human 1561 SQFSLSYEGFSLLPGSLYYWQLPRAFLGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGNNI 1625
Human 1626 MLVASQPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSVPLAASIS 1690
Human 1691 AVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLC 1755
Human 1756 HPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYR 1820
Human 1821 CTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSG 1885
Human 1886 SPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAP 1950
Human 1951 SKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQL 2015
Human 2016 SDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTL 2080
Human 2081 EWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP 2145
Human 2146 ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVA 2210
Human 2211 TSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLP 2275
Human 2276 PHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIE 2340
Human 2341 PSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVG 2405
Human 2406 TSGPLEASVLVTIEAS---VIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGS 2467
Human 2468 LPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSS 2532
Human 2533 SQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSV 2597
Human 2598 PLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPA 2662
Human 2663 RHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSAS 2727
Human 2728 LANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSR 2792
Human 2793 ETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH 2857
Human 2858 QTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA 2922
Human 2923 EGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEA 2987
Human 2988 SVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA 3052
Human 3053 RHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSS 3117
Human 3118 HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGP 3182
Human 3183 EQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELE 3247
Human 3248 DNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKA 3312
Human 3313 VTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTA 3377
Human 3378 QKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE 3442
Human 3443 GDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHG 3507
Human 3508 TPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSL 3572
Human 3573 PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQ 3637
Human 3638 NLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQ 3702
Human 3703 VTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEV 3767
Human 3768 RVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGK 3832
Human 3833 VKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPT 3897
Human 3898 NLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPV 3962
Human 3963 NGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISH 4027
Human 4028 CPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYT 4092
Human 4093 CRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSG 4157
Human 4158 PVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRPVLRSS 4222
Human 4223 PGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYD 4287
Human 4288 SSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPG 4352
Human 4353 FSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEV 4417
Human 4418 RTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTAL 4482
Human 4483 REGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLHSA 4547
Human 4548 RPGAPPPQPLDLQHRAQAGANTRPCPS 4574 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HSPG2 | XP_011539620.1 | SEA | 80..193 | CDD:214554 | 94/112 (84%) |
| LDLa | 216..251 | CDD:238060 | 33/34 (97%) | ||
| LDLa | 302..336 | CDD:238060 | 29/33 (88%) | ||
| LDLa | 342..376 | CDD:238060 | 31/33 (94%) | ||
| LDLa | 385..420 | CDD:238060 | 31/34 (91%) | ||
| IG | 431..507 | CDD:214652 | 69/75 (92%) | ||
| Ig_Perlecan_D2_like | 438..515 | CDD:143220 | 71/76 (93%) | ||
| LamB | 608..734 | CDD:214597 | 109/125 (87%) | ||
| EGF_Lam | 782..824 | CDD:238012 | 38/41 (93%) | ||
| EGF_Lam | 831..888 | CDD:238012 | 56/56 (100%) | ||
| Laminin_EGF | 897..939 | CDD:278482 | 36/41 (88%) | ||
| LamB | 1003..1130 | CDD:214597 | 107/126 (85%) | ||
| EGF_Lam | 1176..1225 | CDD:238012 | 43/48 (90%) | ||
| EGF_Lam | 1227..1282 | CDD:238012 | 52/54 (96%) | ||
| Laminin_EGF | 1293..1340 | CDD:278482 | 41/46 (89%) | ||
| LamB | 1574..1699 | CDD:214597 | 105/124 (85%) | ||
| EGF_Lam | 1746..1794 | CDD:238012 | 44/47 (94%) | ||
| Laminin_EGF | 1796..1851 | CDD:278482 | 50/54 (93%) | ||
| Ig_2 | 1866..1958 | CDD:290606 | 79/91 (87%) | ||
| IG_like | 1866..1946 | CDD:214653 | 68/79 (86%) | ||
| Ig3_Perlecan_like | 1954..2039 | CDD:143231 | 82/84 (98%) | ||
| IG | 1961..2040 | CDD:214652 | 76/78 (97%) | ||
| I-set | 2049..2133 | CDD:254352 | 70/83 (84%) | ||
| Ig | 2063..2133 | CDD:299845 | 57/69 (83%) | ||
| I-set | 2139..2225 | CDD:254352 | 79/85 (93%) | ||
| IGc2 | 2153..2215 | CDD:197706 | 57/61 (93%) | ||
| IG_like | 2240..2317 | CDD:214653 | 63/76 (83%) | ||
| IGc2 | 2247..2307 | CDD:197706 | 48/59 (81%) | ||
| IG | 2341..2418 | CDD:214652 | 65/76 (86%) | ||
| IGc2 | 2348..2408 | CDD:197706 | 53/59 (90%) | ||
| IG_like | 2434..2508 | CDD:214653 | 63/73 (86%) | ||
| IGc2 | 2441..2500 | CDD:197706 | 52/58 (90%) | ||
| IG_like | 2530..2607 | CDD:214653 | 64/76 (84%) | ||
| IGc2 | 2537..2595 | CDD:197706 | 50/57 (88%) | ||
| I-set | 2620..2703 | CDD:254352 | 69/82 (84%) | ||
| IGc2 | 2633..2693 | CDD:197706 | 50/59 (85%) | ||
| IG | 2731..2800 | CDD:214652 | 65/68 (96%) | ||
| IGc2 | 2731..2790 | CDD:197706 | 56/58 (97%) | ||
| IG_like | 2819..2896 | CDD:214653 | 63/76 (83%) | ||
| IGc2 | 2826..2885 | CDD:197706 | 50/58 (86%) | ||
| IG | 2916..2993 | CDD:214652 | 65/76 (86%) | ||
| IGc2 | 2923..2983 | CDD:197706 | 49/59 (83%) | ||
| IG | 3016..3093 | CDD:214652 | 69/76 (91%) | ||
| IGc2 | 3023..3083 | CDD:197706 | 53/59 (90%) | ||
| Ig_2 | 3112..3192 | CDD:290606 | 60/79 (76%) | ||
| IG_like | 3115..3192 | CDD:214653 | 58/76 (76%) | ||
| I-set | 3205..3291 | CDD:254352 | 75/85 (88%) | ||
| ig | 3209..3289 | CDD:278476 | 69/79 (87%) | ||
| IG | 3303..3385 | CDD:214652 | 59/81 (73%) | ||
| Ig | 3313..3382 | CDD:143165 | 50/68 (74%) | ||
| IG | 3404..3478 | CDD:214652 | 60/73 (82%) | ||
| IGc2 | 3409..3468 | CDD:197706 | 49/58 (84%) | ||
| I-set | 3482..3565 | CDD:254352 | 57/82 (70%) | ||
| IGc2 | 3496..3555 | CDD:197706 | 39/58 (67%) | ||
| IG_like | 3589..3666 | CDD:214653 | 67/76 (88%) | ||
| Ig | 3600..3666 | CDD:299845 | 58/65 (89%) | ||
| I-set | 3676..3755 | CDD:254352 | 70/78 (90%) | ||
| IGc2 | 3686..3745 | CDD:197706 | 53/58 (91%) | ||
| I-set | 3764..3841 | CDD:254352 | 67/76 (88%) | ||
| Ig | 3779..3834 | CDD:299845 | 48/54 (89%) | ||
| LamG | 3848..4008 | CDD:238058 | 153/159 (96%) | ||
| EGF_CA | <4035..4064 | CDD:238011 | 26/28 (93%) | ||
| LamG | 4117..4266 | CDD:238058 | 139/148 (94%) | ||
| EGF | 4291..4321 | CDD:278437 | 27/29 (93%) | ||
| EGF_CA | 4328..4359 | CDD:238011 | 26/30 (87%) | ||
| LamG | 4386..4545 | CDD:238058 | 133/158 (84%) | ||
| Hspg2 | XP_030109089.1 | EGF_CA | 4153..4184 | CDD:238011 | 26/30 (87%) |
| LamG | 4211..4369 | CDD:238058 | 133/158 (84%) | ||
| SEA | 80..194 | CDD:382994 | 95/113 (84%) | ||
| LDLa | 216..251 | CDD:238060 | 33/34 (97%) | ||
| Ldl_recept_a | 300..336 | CDD:365841 | 29/35 (83%) | ||
| LDLa | 342..376 | CDD:238060 | 31/33 (94%) | ||
| LDLa | 385..420 | CDD:238060 | 31/34 (91%) | ||
| Ig_Perlecan_like | 438..515 | CDD:143220 | 71/76 (93%) | ||
| LamB | 607..733 | CDD:214597 | 109/125 (87%) | ||
| EGF_Lam | 781..823 | CDD:238012 | 38/41 (93%) | ||
| EGF_Lam | 830..887 | CDD:238012 | 56/56 (100%) | ||
| Laminin_EGF | 896..938 | CDD:365839 | 36/41 (88%) | ||
| Laminin_B | 1007..1141 | CDD:365838 | 112/133 (84%) | ||
| EGF_Lam | 1175..1224 | CDD:238012 | 43/48 (90%) | ||
| EGF_Lam | 1225..1281 | CDD:238012 | 52/55 (95%) | ||
| Laminin_EGF | 1292..1339 | CDD:365839 | 41/46 (89%) | ||
| Laminin_B | 1413..1545 | CDD:365838 | 123/296 (42%) | ||
| EGF_Lam | 1580..1628 | CDD:238012 | 44/47 (94%) | ||
| EGF_Lam | 1629..1686 | CDD:238012 | 51/56 (91%) | ||
| IG_like | 1699..1779 | CDD:214653 | 68/79 (86%) | ||
| Ig_Perlecan_like | 1787..1872 | CDD:143231 | 82/84 (98%) | ||
| IG_like | 1888..1966 | CDD:214653 | 65/77 (84%) | ||
| I-set | 1972..2058 | CDD:369462 | 79/85 (93%) | ||
| IG_like | 2073..2150 | CDD:214653 | 63/76 (83%) | ||
| IG | 2174..2249 | CDD:214652 | 65/76 (86%) | ||
| IG | 2269..2342 | CDD:214652 | 63/72 (88%) | ||
| IG | 2364..2441 | CDD:214652 | 64/76 (84%) | ||
| Ig | 2450..2535 | CDD:386229 | 70/84 (83%) | ||
| IG | 2563..2632 | CDD:214652 | 65/68 (96%) | ||
| IGc2 | 2658..2717 | CDD:197706 | 50/58 (86%) | ||
| IG_like | 2748..2825 | CDD:214653 | 65/76 (86%) | ||
| IG | 2846..2922 | CDD:214652 | 69/75 (92%) | ||
| IG_like | 2943..3021 | CDD:214653 | 58/77 (75%) | ||
| Ig | 3034..3120 | CDD:386229 | 75/85 (88%) | ||
| IG_like | 3132..3213 | CDD:214653 | 59/81 (73%) | ||
| IG | 3230..3306 | CDD:214652 | 61/75 (81%) | ||
| Ig | 3327..3390 | CDD:319273 | 45/62 (73%) | ||
| Ig | 3428..3494 | CDD:386229 | 58/65 (89%) | ||
| Ig | 3518..3583 | CDD:386229 | 60/64 (94%) | ||
| I-set | 3587..3669 | CDD:369462 | 71/81 (88%) | ||
| LamG | 3676..3833 | CDD:238058 | 153/159 (96%) | ||
| EGF_CA | 3856..3889 | CDD:238011 | 29/32 (91%) | ||
| EGF_CA | <3901..3930 | CDD:238011 | 27/28 (96%) | ||
| LamG | 3942..4091 | CDD:238058 | 139/148 (94%) | ||
| EGF | 4116..4146 | CDD:333761 | 27/29 (93%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C83968681 | |
| Domainoid | 1 | 1.000 | 329 | 1.000 | Domainoid score | I14565 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG3509 | |
| HGNC | 1 | 1.500 | - | - | ||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H68473 | |
| Inparanoid | 1 | 1.050 | 4349 | 1.000 | Inparanoid score | I209 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S7730 |
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 1 | 1.010 | - | - | QHG46672 | |
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 1 | 1.000 | - | - | FOG0006846 | |
| OrthoInspector | 1 | 1.000 | - | - | oto113000 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_107789 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR10574 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3412 |
| SonicParanoid | 1 | 1.000 | - | - | X4935 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| 18 | 18.240 | |||||