DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBCD and YHL008C

DIOPT Version :9

Sequence 1:	NP_608648.1	Gene:	TBCD / 33389	FlyBaseID:	FBgn0027509	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_011855.1	Gene:	YHL008C / 856381	SGDID:	S000001000	Length:	627	Species:	Saccharomyces cerevisiae

Alignment Length:	291	Identity:	55/291 - (18%)
Similarity:	97/291 - (33%)	Gaps:	79/291 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 AYDTSTSAPTTNCSPVNHVQSKNTKMDR-IFELIQLYVSSNDTCSSMAAFLAAKYFIRSDIKDLY 224
            :|.|..|..:....|.:.:.|.|..|:. :.|.:|....||.|..|....|.........||.:.
Yeast   331 SYFTGRSLNSLRSIPSSVITSDNVTMESDLGEPVQFIPKSNSTTRSPHLGLPHNLPHNHSIKSIN 395

  Fly   225 LERFLDWIMEQH---------------------------------------QADTLNVKFGQLAA 250
            ..|    |.::|                                       :|:|.|
Yeast   396 RHR----INKRHSLRSPPGVFPVRGMGEPLEREKTIEDATYDPKENELFLRRAETHN-------- 448

  Fly   251 VAAILKHGKREDLLPYADKLLQWITSCQYKDDNDFLKYKNYVKIIQRIG------LVHLKPRIAS 309
             :|.:|:.|:||     |.||:.:.:.:.::..::.|...|..:..:.|      :.||...::|
Yeast   449 -SAYVKNKKKED-----DNLLRLVKTEEDREQKEYEKNGGYNILENKPGTRLEKIITHLAENVSS 507

  Fly   310 WRYKRGTRSLATNLNQTT----AAGGEPVVLE--QSLEEGEEIVVPDAIEEVIEELLQALRSGGN 368
               :..|..:.....|.|    |....|...:  .||.:.....:......|.:|...:..:...
Yeast   508 ---REVTPPILPRTTQDTFPHNAPASSPAYTDDAHSLRKANSTTLGGLFRAVSKEFHSSKDAESP 569

  Fly   369 D--IRWSAAKGLGRVTNRLPKELADEVIGSV 397
            |  ::..||.|:    ||..:..|:.|.|.|
Yeast   570 DDLLKKMAAVGI----NRNARITANNVAGIV 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBCD	NP_608648.1	TFCD_C	24..>584	CDD:303064	55/291 (19%)
		HEAT repeat	355..383	CDD:293787	6/29 (21%)
		HEAT repeat	393..423	CDD:293787	3/5 (60%)
		TFCD_C	890..1075	CDD:289385
YHL008C	NP_011855.1	FocA	3..269	CDD:225027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2116
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900