Protein Alignment Tbcd and TTN1

DIOPT Version :10

• Sequence 1: NP_608648.1
• Gene: Tbcd / 33389
• FlyBaseID: FBgn0027509
• Length: 1189
• Species: Drosophila melanogaster
• Sequence 2: NP_191633.3
• Gene: TTN1 / 825245
• AraportID: AT3G60740
• Length: 1254
• Species: Arabidopsis thaliana
• Alignment Length: 1273
• Identity: 409/1273 - (32%)
• Similarity: 644/1273 - (50%)
• Gaps: 196/1273 - (15%)

  Fly     6 EECKDEDLPANTLEHF--TELQQVLEMIDNIKSIAANTFEREFEQYAQVLSRYQEQPHLLDPHLE 68
            ||..:.|.....|:.:  .|.:.|..::|:|.|...........:...::.:||||..|::|:||
plant    24 EEDDEHDSKERVLQRYFLQEWKLVKSLLDDIVSNGRVVDPTSVHKIRSIMDKYQEQGQLVEPYLE 88

  Fly    69 ELLGKLLHKIR--------KPDLDTGELHAAFK----YLYIICKVRTYKVLVKFMPHELSDLEFV 121
            .::..|:..||        |||    |:....|    .:|.:..|..||.::||.||::||||..
plant    89 SIVSPLMFIIRSKTVDLEAKPD----EILEIIKPISIIIYALVTVCGYKAVIKFFPHQVSDLELA 149

  Fly   122 LDL------------LGQQNPKEFEQWETRYILLLWMSILVLNPFHMSRLDAYDTSTSAPTT--- 171
            :.|            |.|::..|.   |.:.:.|||:|||||.||.:|   :.|||.:...|
plant   150 VLLLEKCHSTNSVSALRQESTGEM---EAKCVTLLWLSILVLVPFDIS---SVDTSIADDKTFGV 208

  Fly   172 -NCSPVNHVQSKNTKMDRIFELIQLYVSSNDTCSSMAAFLAAKYFIRSDIKDLYLERFLDWIME- 234
             :.:|:         :.:|....:.|:.|......::..|.:|...|.|:...: ..|.:|..|
plant   209 DDLAPL---------VLKILGFCKDYLCSAGPMRRISGLLLSKLLTRPDMGKAF-SSFFEWTYEV 263

  Fly   235 -QHQADTLNVKF---GQLAAVAAILKHGKREDLLPYADKLLQWIT--SCQYKDDNDFLKYKNYVK 293
             ..:.|::...|   |.:.|::||.|...|:.||.....:|..:|  |.........|..|..:|
plant   264 LSCKEDSVTNHFRLLGVMEALSAIFKTASRKVLLDVLPIVLNDVTVLSKSNAAAKSSLLRKYLIK 328

  Fly   294 IIQRIGLVHLKPRIASWRYKRGTRSLATNLNQTTAAGGEP------VVLEQSL--EEGEEIVVPD 350
            :.||||||.|..|..||||...|.||:.|::.:::....|      ::..:||  :|.|::.||:
plant   329 LTQRIGLVCLPHRSPSWRYVAQTASLSENMSTSSSQRLAPDHTVTAILQPESLDDQEDEDMDVPE 393

  Fly   351 AIEEVIEELLQALRSGGNDIRWSAAKGLGRVTNRLPKELADEVIGSVIDILNPLEPHEAWHGACL 415
            .:||:||.||..||.....:|||||||:||||:||...|:|||:.||:::.:|.|...:|||.||
plant   394 ILEEIIEMLLSGLRDTDTVVRWSAAKGIGRVTSRLTSVLSDEVLSSVLELFSPGEGDGSWHGGCL 458

  Fly   416 ALAELAKRGLLLPHRLEELVPLLMQALFYDEMKGYMSVGQHIRDSACYMCWAFARAYNPDDVKPF 480
            ||||||:||||||.....:||::::||.||..:|..|||.|:||:|.|:||||.|||:..|:|..
plant   459 ALAELARRGLLLPRSFPLVVPVIVKALHYDVRRGPHSVGSHVRDAAAYVCWAFGRAYSHKDMKNV 523

  Fly   481 VHKISSGLLTVAVFDREVNCRRAASAAFQESVGRLGNFPFGIEISTTTDFYSVGIRQNSYLNISD 545
            :.:::..||.|..|||||||||||:|||||:|||.||:|.||:|.:..|::|:..|.||||.::.
plant   524 LDQLAPDLLIVGSFDREVNCRRAAAAAFQENVGRQGNYPHGIDIVSIADYFSLSSRVNSYLQVAV 588

  Fly   546 YIAQFEVYREPLINHLVQHKVSHWDSAIRELTAKALHKLSLWEPEYMAAVVLPQLLAKTDTIDIN 610
            .|||:|.|..|.::.|:.:|:.|||.::|||.|:||..|..:||::.|..||.:|:..|.:.|:.
plant   589 SIAQYEGYLYPFVDELLYNKICHWDKSLRELAAEALAPLVKYEPKHFANYVLEKLIPCTLSTDLC 653

  Fly   611 CRHGCVLAMGEITLTLRKLEEKSDPQVVYL----SNQRVAELNELIITFLDK-NFYRGMSGDLMK 670
            .|||..||.||:.|.|.        |..|:    |.:|:|.    |:..::| ..|||..|::|:
plant   654 MRHGATLAAGEVVLALH--------QCGYVLSADSQKRMAG----IVPSIEKARLYRGKGGEIMR 706

  Fly   671 SCTSSYIKNCSLAKL---QATPECLVSWQKVIDSCLITKSNAIRDGAVEAFGELCTTYYCSDSRH 732
            ...|.:|:..||:.:   :.|...|:.   .:...|...::.|::.||.|..:|
plant   707 LAVSRFIECISLSHVTLAERTERILLD---TLTENLRHPNSQIQNAAVSAVKQL----------- 757

  Fly   733 GENEAIINTYLTGAD--------------NDLEEHIRMGYIAALGVLPSFMIRCHLQAI---LDS 780
                  :.:||.|.|              .|....:|.|...||||||..::....:.|   |.|
plant   758 ------VQSYLVGNDKKSVDLILKHLKHLTDPNVAVRRGSALALGVLPYELLTAKWKDIVLKLCS 816

  Fly   781 LVKHSLTPLQAVLVGEMGDRENIQAYRWSEARTQSVLALTKLVKTVGYGGGIDSFAEPKNFN--- 842
            ..|..:.|         .||:       :|||..:|..||.:.:|:......|    |.|.:
plant   817 ACKIEVNP---------EDRD-------AEARVNAVKGLTSVCETLTQKRASD----PGNDDLSL 861

  Fly   843 ------KVIECLLRALQEYTLDNRGDIGAWVREAAMSSL------------------YEIVTTCP 883
                  :|::.||:||.:|::|||||:|:||||||:..|                  |...|:
plant   862 FLLIKTEVMDTLLKALDDYSVDNRGDVGSWVREAAVHGLEKCTYILCKKMETYSEGDYNDDTS-- 924

  Fly   884 PDLLAPEQVHEIVVGFMQQAVEKIDRTRGLGGRLCCQLIHHQ----PRIPYIREHSKLLEIFPAD 944
             .|........::.|.::|.|||:|:.|....::..::::|:    |.:|| ||  ||.||.|..
plant   925 -SLFDSNLATRLIGGMLKQGVEKMDKLRETAAKVLQRILYHKSVSVPHVPY-RE--KLEEILPNK 985

  Fly   945 ADSVLWLFADHTFPLFCELLSLPDYSKRVLLGLSASIGQLTESLIKYASSALFHFLRSNPETVPR 1009
            | ::.|.....:||.|.:||.|..|||.|:.||..|||.|.:||.|.:..||..::|......|:
plant   986 A-NLQWAVPAFSFPRFVQLLKLRCYSKEVMSGLVISIGGLQDSLRKASLVALLEYMREGEAKDPK 1049

  Fly  1010 --------LCSEVVQIFEEHLLNERVTYPLLSFLDILIGSGTVESVLHDEANPFA--EDIFRLLN 1064
                    |..:::.|.:|:...:||..|.|..::||..|   :..|:.|:..|:  ..:...|.
plant  1050 EQQSRESALGDDILWILQEYKKCDRVMVPCLQTIEILFSS---KIFLNQESYTFSFYAGVMDSLA 1111

  Fly  1065 LEVKGYKKLYKTATSISAFCQLLQVPR-LSKRILSKLSVFLGLQHVHVRKTAATKLYEALALHGD 1128
            :|::..|...|....::....:..|.. :|.:..|:|..|||.::..:||.||.::|.||..:|.
plant  1112 IELRASKDFTKLKAGLAILGYIASVSHFISTKAFSQLLSFLGHRYPMIRKAAAEQVYLALLQNGI 1176

  Fly  1129 VTEVPEENMDEILTLLSETDWTQPLVEVRPLRNQLCQL 1166
            :  |.||.|::::.::||:.|...:...:..|.:||:|
plant  1177 L--VTEEKMEKVIEIISESCWEADMETTKTQRLELCEL 1212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbcd	NP_608648.1	TFCD_C	24..>584	CDD:473247	224/602 (37%)
		HEAT repeat	355..383	CDD:293787	16/27 (59%)
		HEAT repeat	393..423	CDD:293787	16/29 (55%)
		TFCD_C	893..1075	CDD:463643	59/195 (30%)
TTN1	NP_191633.3	TFCD_C	<376..>988	CDD:473247	241/670 (36%)
		HEAT repeat	732..756	CDD:293787	5/26 (19%)
		HEAT repeat	773..800	CDD:293787	8/26 (31%)
		HEAT repeat	810..845	CDD:293787	13/50 (26%)
		HEAT repeat	868..900	CDD:293787	18/31 (58%)
		TFCD_C	933..1122	CDD:463643	59/195 (30%)