DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TBCD and TBCD

DIOPT Version :9

Sequence 1:NP_608648.1 Gene:TBCD / 33389 FlyBaseID:FBgn0027509 Length:1189 Species:Drosophila melanogaster
Sequence 2:NP_005984.3 Gene:TBCD / 6904 HGNCID:11581 Length:1192 Species:Homo sapiens


Alignment Length:1202 Identity:480/1202 - (39%)
Similarity:713/1202 - (59%) Gaps:67/1202 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 EECKDEDLP-ANTLEHFTELQQVLEMIDNIKSIAANTFERE--FEQYAQVLSRYQEQPHLLDPHL 67
            ||.:||.|. ...||.|.|..:...::..::.:.....|||  .|::..::.:||||||||||||
Human    14 EEAEDETLAFGAALEAFGESAETRALLGRLREVHGGGAEREVALERFRVIMDKYQEQPHLLDPHL 78

  Fly    68 EELLGKLLHKIRKPDLDTGELHAAFKYLYIICKVRTYKVLVKFMPHELSDLEFVLDLLGQQNPKE 132
            |.::..||..::........:|.|||:||||.|||.||..::..|||::|:|.||||:..||||:
Human    79 EWMMNLLLDIVQDQTSPASLVHLAFKFLYIITKVRGYKTFLRLFPHEVADVEPVLDLVTIQNPKD 143

  Fly   133 FEQWETRYILLLWMSILVLNPFHMSRLDAYDTSTSAPTTNCSPVNHVQSKNTKMDRIFELIQLYV 197
            .|.|||||:||||:|:..|.||..||||.  ...:.|.         |::.:.||||.::.:.|:
Human   144 HEAWETRYMLLLWLSVTCLIPFDFSRLDG--NLLTQPG---------QARMSIMDRILQIAESYL 197

  Fly   198 SSNDTCSSMAAFLAAKYFIRSDIKDLYLERFLDWI---MEQHQADTLN---VKFGQLAAVAAILK 256
            ..:|.....||.|.:::..|.|:|...:..||||.   :.:....|:.   ...|.|.|:|.|.|
Human   198 IVSDKARDAAAVLVSRFITRPDVKQSKMAEFLDWSLCNLARSSFQTMQGVITMDGTLQALAQIFK 262

  Fly   257 HGKREDLLPYADKLLQWITSCQYKDDNDFLKYKNYVKIIQRIGLVHLKPRIASWRYKRGTRSLAT 321
            ||||||.||||..:|:.:..|:..:.|..|..|..||::||:||..|||::|:|||:||.||||.
Human   263 HGKREDCLPYAATVLRCLDGCRLPESNQTLLRKLGVKLVQRLGLTFLKPKVAAWRYQRGCRSLAA 327

  Fly   322 NLNQTTAAGGE--PVVLEQSLEEGEEIVVPDAIEEVIEELLQALRSGGNDIRWSAAKGLGRVTNR 384
            ||...|....|  |::|.:..:|.::  ||:.:|.|||:||..|:.....:|||||||:||:..|
Human   328 NLQLLTQGQSEQKPLILTEDDDEDDD--VPEGVERVIEQLLVGLKDKDTVVRWSAAKGIGRMAGR 390

  Fly   385 LPKELADEVIGSVIDILNPLEPHEAWHGACLALAELAKRGLLLPHRLEELVPLLMQALFYDEMKG 449
            ||:.|||:|:|||:|..:..|..:||||.|||||||.:||||||.||.::|.::::||.|||.:|
Human   391 LPRALADDVVGSVLDCFSFQETDKAWHGGCLALAELGRRGLLLPSRLVDVVAVILKALTYDEKRG 455

  Fly   450 YMSVGQHIRDSACYMCWAFARAYNPDDVKPFVHKISSGLLTVAVFDREVNCRRAASAAFQESVGR 514
            ..|||.::||:|||:||||||||.|.::||||..|||.|:..|||||::||||||||||||:|||
Human   456 ACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIAAVFDRDINCRRAASAAFQENVGR 520

  Fly   515 LGNFPFGIEISTTTDFYSVGIRQNSYLNISDYIAQFEVYREPLINHLVQHKVSHWDSAIRELTAK 579
            .|.||.||:|.||.|:::||.|.|.:|.||.:||.|..|.:|:|:|||..|:||||..||||.|:
Human   521 QGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAAR 585

  Fly   580 ALHKLSLWEPEYMAAVVLPQLLAKTDTIDINCRHGCVLAMGEITLTLRKL-EEKSDPQVVYLSNQ 643
            |||.|:...||:.|..|.|:||:.|.:.|::.|||.:||..|:...|.|| .:::.|...:|..|
Human   586 ALHNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQ 650

  Fly   644 RVAELNELIITFLDKNFYRGMSGDLMKSCTSSYIKNCSLAKLQATPECLV-SWQKVIDSCL---- 703
            .|..|.::.....|:..|||:.|.||:......|:..||:|:....:.:: .||.:|:..|    
Human   651 AVQGLKQIHQQLYDRQLYRGLGGQLMRQAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLH 715

  Fly   704 ITKSNA---IRDGAVEAFGELCTTYYCSDSRHGE---NEAIINTYLTGADNDLEEHIRMGYIAAL 762
            :..|::   ::|.||.|...||:.||..:....:   .|.:|..||....|. ||..|.|:..||
Human   716 LISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP-EEMTRCGFSLAL 779

  Fly   763 GVLPSFMIRCHLQAILDSL--VKHSLTPLQAVLVGEMGDRENIQAYRWSEARTQSVLALTKLVKT 825
            |.||.|:::..||.:|..|  |.|: :|            |::.   ::|:|...:.|:.::.:|
Human   780 GALPGFLLKGRLQQVLTGLRAVTHT-SP------------EDVS---FAESRRDGLKAIARICQT 828

  Fly   826 VGY-GGGIDSFAEPKNFNKVIECLLRALQEYTLDNRGDIGAWVREAAMSSLYE---IVTTCPPDL 886
            ||. .|..|.....:|.:::...||..:.:||.|:|||:|.|||:|||:||.:   ::....|:|
Human   829 VGVKAGAPDEAVCGENVSQIYCALLGCMDDYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPEL 893

  Fly   887 LAPEQVHEIVVGFMQQAVEKIDRTRGLGGRLCCQLIH-HQPRIPYIREHSKLLEIFP-ADADSVL 949
            :.......|:....|||.|||||.|.....:...|:| ..|.||::....:|.::|| :|..||.
Human   894 IEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEKLFPRSDVASVN 958

  Fly   950 WLFADHTFPLFCELLSLPDYSKRVLLGLSASIGQLTESLIKYASSALFHFLR---SNPETVPRLC 1011
            |......||...:||.||.|...|||||..|:|.||||.|::::.:||.:::   |:|:.:....
Human   959 WSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFS 1023

  Fly  1012 SEVVQIFEEHLLNERVTYPLLSFLDILIGSGTVESVLHDEANPFAEDIFRLLNLEVKGYKKLYKT 1076
            ..::||||::||||||:.|||..||.::..|..:....:|.:|||..:..|...|:|..|.:.|.
Human  1024 GTLLQIFEDNLLNERVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKL 1088

  Fly  1077 ATSISAFCQLLQVP-RLSKRILSKLSVFLGLQHVHVRKTAATKLYEALALHGDVTEVPEENMDEI 1140
            .:.|:.||:::|.| .:.::.|.:|.:.|..:...:|||.|:::||.|..:.||  |..:.:||:
Human  1089 LSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDV--VGADVLDEV 1151

  Fly  1141 LTLLSETDWTQPLVEVRPLRNQLCQLMDIKPP 1172
            :|:||:|.|...|..||..||:||.|:.:..|
Human  1152 VTVLSDTAWDAELAVVREQRNRLCDLLGVPRP 1183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBCDNP_608648.1 TFCD_C 24..>584 CDD:303064 268/569 (47%)
HEAT repeat 355..383 CDD:293787 15/27 (56%)
HEAT repeat 393..423 CDD:293787 17/29 (59%)
TFCD_C 890..1075 CDD:289385 69/189 (37%)
TBCDNP_005984.3 TFCD_C 63..>914 CDD:303064 367/876 (42%)
HEAT 1 361..399 20/37 (54%)
HEAT 2 557..594 21/36 (58%)
HEAT 3 596..632 15/35 (43%)
TFCD_C 897..1087 CDD:289385 70/194 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144547
Domainoid 1 1.000 661 1.000 Domainoid score I152
eggNOG 1 0.900 - - E1_COG2116
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4368
Inparanoid 1 1.050 832 1.000 Inparanoid score I457
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55142
OrthoDB 1 1.010 - - D79003at2759
OrthoFinder 1 1.000 - - FOG0004779
OrthoInspector 1 1.000 - - oto91319
orthoMCL 1 0.900 - - OOG6_102599
Panther 1 1.100 - - LDO PTHR12658
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R52
SonicParanoid 1 1.000 - - X3933
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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