Protein Alignment Tbcd and tbcd

DIOPT Version :10

• Sequence 1: NP_608648.1
• Gene: Tbcd / 33389
• FlyBaseID: FBgn0027509
• Length: 1189
• Species: Drosophila melanogaster
• Sequence 2: XP_073801066.1
• Gene: tbcd / 553265
• ZFINID: ZDB-GENE-060823-1
• Length: 1191
• Species: Danio rerio
• Alignment Length: 1211
• Identity: 490/1211 - (40%)
• Similarity: 707/1211 - (58%)
• Gaps: 72/1211 - (5%)

  Fly     4 SVEE--CKDED----LPANTLEHFTELQQVLEMIDNIKSIAANTFERE--FEQYAQVLSRYQEQP 60
            ||.|  |..||    ..|..|..|||..:...:|.::..|..:|..||  .|::..::.||||||
Zfish     2 SVMEGACNGEDAEVLAQACVLSEFTESTETRALISSLPDIHHDTVSREATIEKFVVIMDRYQEQP 66

  Fly    61 HLLDPHLEELLGKLLHKIRKPDLDTGELHAAFKYLYIICKVRTYKVLVKFMPHELSDLEFVLDLL 125
            ||||||||.:|..||..||........:|..||:||||.|||.||:.::..|||:||::.|||||
Zfish    67 HLLDPHLEWMLNMLLEMIRSEKSPPLLVHLCFKFLYIISKVRGYKIFMQLFPHEVSDVQPVLDLL 131

  Fly   126 GQQNPKEFEQWETRYILLLWMSILVLNPFHMSRLDAYDTSTSAPTTNCSPVNHVQSKNTKMDRIF 190
            .:|:.|:.|.||||||||||:|:..|.||.:||||.:  .::.|.||         :.:.||||.
Zfish   132 CRQDQKDTETWETRYILLLWLSMTCLIPFDLSRLDGH--LSTVPGTN---------RESTMDRIL 185

  Fly   191 ELIQLYVSSNDTCSSMAAFLAAKYFIRSDIKDLYLERFLDWIM---EQHQADTLN---VKFGQLA 249
            |:.:.::..:|.....|:.|.:|:..|.|:|...|..||||.:   .|....|:.   :..|.|.
Zfish   186 EVAKSFLRVSDKSRDAASVLVSKFVTRPDVKQKRLGDFLDWCLTTISQSSEMTMEGTVILDGALQ 250

  Fly   250 AVAAILKHGKREDLLPYADKLLQWITSCQYKDDNDFLKYKNYVKIIQRIGLVHLKPRIASWRYKR 314
            ::|.:.|||||:|.|.||..:|:.:...:..:.|.....|..||::||:||..||||:|.|||:|
Zfish   251 SLAQLFKHGKRDDFLQYAPTVLECLNQKKIAESNQATLRKLGVKVVQRLGLTFLKPRLAKWRYQR 315

  Fly   315 GTRSLATNLNQTTAAGGEPVVLE----QSLEEGEEIVVPDAIEEVIEELLQALRSGGNDIRWSAA 375
            |:||||.||.|::..  |.|...    :|:.:.|:..:|..:|.|||:||..|:.....:|||:|
Zfish   316 GSRSLAVNLAQSSVT--ESVEATKPDLESVSQEEDYDIPQEVENVIEQLLLGLKDKETIVRWSSA 378

  Fly   376 KGLGRVTNRLPKELADEVIGSVIDILNPLEPHEAWHGACLALAELAKRGLLLPHRLEELVPLLMQ 440
            ||:||||.||||||||:|:.||:|..:..|...||||.|||||||.:||||||.||.::|||:::
Zfish   379 KGIGRVTGRLPKELADDVVESVLDCFSFQETDNAWHGGCLALAELGRRGLLLPSRLSDVVPLILK 443

  Fly   441 ALFYDEMKGYMSVGQHIRDSACYMCWAFARAYNPDDVKPFVHKISSGLLTVAVFDREVNCRRAAS 505
            ||.|||.:|..|:|.::||:.||:||||||||.|.::||:|::|:|.|:...||||.|.||:|||
Zfish   444 ALTYDEKRGACSLGSNVRDAGCYVCWAFARAYEPTELKPYVNQIASSLVIATVFDRNVTCRKAAS 508

  Fly   506 AAFQESVGRLGNFPFGIEISTTTDFYSVGIRQNSYLNISDYIAQFEVYREPLINHLVQHKVSHWD 570
            |||||:|||.|.||.||:|.|..|:::||...|.||.||.|||.||.|.:|||:|||..|::|||
Zfish   509 AAFQENVGRQGTFPHGIDIITAADYFTVGNLNNCYLTISVYIAGFEEYTKPLIDHLVAMKINHWD 573

  Fly   571 SAIRELTAKALHKLSLWEPEYMAAVVLPQLLAKTDTIDINCRHGCVLAMGEITLTLRKLEEKSDP 635
            .|||||..||||.|::..|||||..||||||.....:|::.|||.:||..|||..|.||..:::.
Zfish   574 GAIRELATKALHNLTIQAPEYMANTVLPQLLPMATGMDLHSRHGAILACAEITHALYKLAAQNNR 638

  Fly   636 QVV-YLSNQRVAELNELIITFLDKNFYRGMSGDLMKSCTSSYIKNCSLAKLQATPECLVS-WQKV 698
            .|. .:|:..:..|.::.....|:..|||..|:||:....|.|:..||:|:....|.::: ||.:
Zfish   639 SVTDLMSSDTIEGLKDIHQKLSDRKQYRGFGGELMRPAVCSLIEKLSLSKMPFKDEPVIAGWQWL 703

  Fly   699 IDSCL----ITKS---NAIRDGAVEAFGELCTTYYCSDSRHGE---NEAIINTYLTGADNDLEEH 753
            ||..|    :..|   ..|:|.||.|...||..||..:....:   .|.:::.||:...:. |..
Zfish   704 IDDSLKNLHLFSSGVRRGIQDAAVSALAALCWQYYQVEPGVADVKMQEELVSQYLSALQSP-EVL 767

  Fly   754 IRMGYIAALGVLPSFMIRCHLQAILDSLVKHSLTPLQAVL-VGEMGDRENIQAYRWSEARTQSVL 817
            .|.|...|||.||.|||...||.||..        |||.. |.:.|:       ..:|||..:..
Zfish   768 TRCGCALALGSLPPFMIHNKLQQILSG--------LQATCRVAQKGE-------SLTEARRDAAT 817

  Fly   818 ALTKLVKTVGY--GGGIDSFAEPKNFNKVIECLLRALQEYTLDNRGDIGAWVREAAMSSLYEI-- 878
            |::::...||.  .|..|......|...|.|.||..:.:|:.|:|||:|||||.||||||.::
Zfish   818 AMSQVCVAVGVCAQGRPDQVLCEDNIRPVYEALLGCMNDYSTDSRGDVGAWVRAAAMSSLMDVTL 882

  Fly   879 -VTTCPPDLLAPEQVHEIVVGFMQQAVEKIDRTRGLGGRLCCQLIHH-QPRIPYIREHSKLLEIF 941
             |....|:||:.:.|..::....|||.|||||.|...|.:..:|:|. .|.:|:|..|.:||.||
Zfish   883 LVVASAPELLSSDIVLRMMCCLAQQAAEKIDRYRAHAGTVFLRLLHSTDPAVPHIPHHEELLSIF 947

  Fly   942 PAD-ADSVLWLFADHTFPLFCELLSLPDYSKRVLLGLSASIGQLTESLIKYASSALFHFLRSNPE 1005
            |.: .:|:.|..|...||...:||.||.|....||||..|:|.||||.::::|.:||.:|:...:
Zfish   948 PPETGNSLNWNAASQAFPHITQLLRLPQYQYHTLLGLCVSVGGLTESTVRFSSQSLFDYLKGIQQ 1012

  Fly  1006 ---TVPRLCSEVVQIFEEHLLNERVTYPLLSFLDILIGSGTVESVLHDEANPFAEDIFRLLNLEV 1067
               .:.:....:::||.::|.|:||:.|||..:|.::.:|..:.....|::||..::..|...|:
Zfish  1013 DFTMLQQFGDTLLRIFRDNLRNDRVSVPLLKMVDQILANGCFDLFTRQESHPFCVELLSLCKEEI 1077

  Fly  1068 KGYKKLYKTATSISAFCQLLQVP-RLSKRILSKLSVFLGLQHVHVRKTAATKLYEALALHGDVTE 1131
            |..|.:.|..:.|:.||.|:|.| .:.|::|.:|.:.|......:|||.|:::||.|..:.||.|
Zfish  1078 KKSKDVQKLLSCIAVFCGLVQFPGDVRKKVLVQLLMLLCHPFPLIRKTTASQVYEMLLTYDDVIE 1142

  Fly  1132 VPEENMDEILTLLSETDWTQPLVEVRPLRNQLCQLMDIKPP 1172
             .|:.:.:::..||:|:|...:..||..|||||..:.:..|
Zfish  1143 -DEQVLADVMASLSDTNWESDIATVRSHRNQLCDWLGVPKP 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbcd	NP_608648.1	TFCD_C	24..>584	CDD:473247	270/571 (47%)
		HEAT repeat	355..383	CDD:293787	15/27 (56%)
		HEAT repeat	393..423	CDD:293787	16/29 (55%)
		TFCD_C	893..1075	CDD:463643	63/186 (34%)
tbcd	XP_073801066.1	None