Protein Alignment TBCD and alp1

DIOPT Version :9

• Sequence 1: NP_608648.1
• Gene: TBCD / 33389
• FlyBaseID: FBgn0027509
• Length: 1189
• Species: Drosophila melanogaster
• Sequence 2: NP_596393.2
• Gene: alp1 / 2539669
• PomBaseID: SPBC11C11.04c
• Length: 1105
• Species: Schizosaccharomyces pombe
• Alignment Length: 1274
• Identity: 291/1274 - (22%)
• Similarity: 504/1274 - (39%)
• Gaps: 303/1274 - (23%)

  Fly    10 DEDLPANTLEHFTELQQVLE------MIDNIKSIAANTFEREFEQYAQVLSRYQEQPHLLDPHLE 68
            ||.|..:.|...  |..||:      .::.:|.:|.     ::.|:.|.      ||.|||..|.
pombe    14 DESLITSRLSQI--LDDVLDDRSSSHSVEKLKDVAV-----KYLQFCQF------QPTLLDKLLS 65

  Fly    69 EL---LGKLLHKIRKPDLDTGELHAAFKYLYIICKVRTYKVLVKFMPHELSDLEFVLDLLGQQNP 130
            :.   |...|.|::    :.|:.::....||..||:|.||.:....|   ..::::.:|....|.
pombe    66 KYVPNLASYLLKVK----NIGKCNSITVILYQFCKIRGYKAVRVLFP---VGVQYIKELYTLLNE 123

  Fly   131 KEFEQWETRYILLLWMSILVLNPFHMSRLDAYDTSTSAPTTNCSPVNHVQSKNTKMDRIFELIQL 195
            .....|...||:|||:|..:..||.::.||                :.:..|.|    |:.:...
pombe   124 SSNNTWHFHYIVLLWLSQALNTPFPLNSLD----------------DSLDVKKT----IYTIAIK 168

  Fly   196 YVSSNDTCSSMAAFLAAKYFIRSDIKDLYLERFLDWIMEQHQADTLNVKFGQLAAVAAILKHGKR 260
            |:.::......:..:.::.|.|.|..||.| .||..........::..|.|.|.::::.||...|
pombe   169 YLENSGIDKEASCLVLSRLFSRDDGLDLLL-GFLHHCESSWFKRSIFYKIGCLFSLSSFLKICPR 232

  Fly   261 EDLLPYADKLLQWITSCQ---YKDDNDFLKYKNYVKIIQRIGLVHLKPRIA-SWRYKRGTRSLAT 321
            .|.|...|...|::...:   ...:|..|: |...|...|:|:|.|....: :|:|.........
pombe   233 NDCLQTVDVAFQFLNVAREDLVGQENSALR-KLLCKCYTRLGIVLLPVNSSPNWKYSISNPDSFF 296

  Fly   322 NLNQTTAAGGEPVVLEQSLEEGEEIVVPDAIEEVIEELLQALRSGGNDIRWSAAKGLGRVTNRLP 386
            .|..               :..||:.:  .:|.:::.||.::....:.:||||||||.::.:|||
pombe   297 QLPD---------------DSNEEVHI--YLEVIVDFLLSSVSDIDSFVRWSAAKGLAKIISRLP 344

  Fly   387 KELADEVIGSVIDI------LNPLE--------PHEAWHGACLALAELAKRGLLLPHRLEELVPL 437
            ..||::||.::|::      |||:|        ....||||.|..|:||..||:...:...::||
pombe   345 WNLAEQVIDAIIELMTENMFLNPIENTVNISITSPLVWHGAILFFAKLAGAGLIKYSKCLHILPL 409

  Fly   438 LMQALFYDEMKGYMSVGQHIRDSACYMCWAFARAYNPDDVKPFVHKISSGLLTVAVFDREVNCRR 502
            :...|.|:...|....||.|||::||..|:|...|:...::.....:...||...:||.|:|.||
pombe   410 IEVGLSYEVRYGTRVTGQSIRDASCYFVWSFYHCYSKSAIEGLQTNLILCLLQTVLFDNEINVRR 474

  Fly   503 AASAAFQESVGRLGNFPFGIEISTTTDFYSVGIRQNSYLNISDYIAQFEVYREPLINHLVQHKVS 567
            ||:||..|.:||..:.|.|:.:.:..::.||....|.|.::...:|.|..:|..:...|..: :.
pombe   475 AATAALFEVIGRHASIPDGLSLISHINYVSVTDISNCYGDLCMKVAHFPQFRSCVFQRLFTN-LQ 538

  Fly   568 HWDSAIRELTAKALHKLSLWEPEYMAAVVLPQLL-----AKTDTI-------------------- 607
            |||..:::|:|.:|.:||:..|:.: ::.||.:|     ...|.|
pombe   539 HWDVKVQQLSAFSLRQLSIKYPKEL-SIYLPPILDYLSVGNADFIFGYTIGLASIIGGFLSISFP 602

  Fly   608 -DINCRHGCVLAMGEITLTLRKLEEKSDPQV----------VYLSNQRV-----AELNELIITFL 656
             |||..|.  |...:..|:|:|...:...::          ::.::.||     :|...:||..:
pombe   603 FDINRIHD--LLSHKNLLSLKKFSRQQQTKIILGILKGIQQIFANDIRVDRAFFSEAFSVIIAAI 665

  Fly   657 DKNFYRGMSGDLMKSCTSSYIKNCSLAKLQATPECLVSWQKVIDSCLITKSNAIRDGAVEAFGEL 721
            |.     ....::|..:.:|........::.|.|.|:.:              ||.
pombe   666 DL-----QEETIIKDISDAYSVLVKFDDMEETLEVLLDY--------------IRK--------- 702

  Fly   722 CTTYYCSDSRHGENEAIINTYLTGADNDLEEHIRMGYIAALGVLPSFMIR-----CHLQAILDSL 781
                 ||.|:..                     |:.|| .|..||:...|     |.|  :||..
pombe   703 -----CSTSKEA---------------------RIVYI-ILQNLPNISFRYQKKICKL--LLDIY 738

  Fly   782 VK-HSLTPLQAVLVGEMGDRENIQAYRWSEARTQSVLALTKLVKTVGYGGGIDSFAEPKNFNKVI 845
            .: ||: ..||.:...:                |:::..|              :.:.::..:.:
pombe   739 PQLHSI-DYQAPVANAL----------------QNIIPFT--------------YEKTESIEEFV 772

  Fly   846 ECLLRALQEYTLDNRGDIGAWVREAAMSSLYEIVTTCPPDLLAPEQVHEIVVGF-MQQAVEKIDR 909
            :.||:....|..|.|||:|:|:|:.||.::..::..........|.:....:.: ::|..:|||.
pombe   773 KELLQVCSNYLTDTRGDVGSWIRKPAMKAISSLLVKDSSGKKLSEDIVWCCISYIIRQTFDKIDS 837

  Fly   910 TRGLGGRLCCQLIHHQPRIPY-IREHSKLLEIF------PADADSVLWLFADHTFPLFCELLSLP 967
            .|||..:...|:     |:.| ||....|..|.      |.....||       ..|...||.:|
pombe   838 LRGLAYQALEQI-----RVHYLIRRCEALTNIINRIRNNPNMDGEVL-------NELNISLLEIP 890

  Fly   968 DYSKRVLLGLSASIG---------QLTESLIKYASSALFHFLRSNPETVPRLCSEVVQIFEEHLL 1023
            :...:...|::....         :..|..:.|.......|.:||.....|   :::|::.:.|.
pombe   891 NLRLQAFYGITVFTADGFGSDLAVKCFEFYLSYVYQLEDSFKKSNSRYGKR---DLLQLYIDILS 952

  Fly  1024 NE----RVTYPLLSFLDILIGSGTVESVLHDEANPFAEDIFRLLNLEVKGYKKLY---------- 1074
            :|    |..:|::.....|:..|    ...|..|             |||..|..
pombe   953 SEDEIARFYFPIMKSFTSLLAYG----CFTDFQN-------------VKGMSKAIFIVQRRALTC 1000

  Fly  1075 KTATSISAFCQLLQVPRLSKRIL-----SKLSVFLGLQHVH-VRKTAATKLYEALALHGDVTEVP 1133
            |:...:||..:|.:...|||..|     .|.:..|.|..:. ||..||..|..|.:: |.:|.:|
pombe  1001 KSPGGLSAILELYRTLFLSKNELLRHHALKYTANLLLNPIEKVRYQAADTLLYAKSI-GLLTFLP 1064

  Fly  1134 EENMDEILTLLSETDWTQPLVE----VRPLRNQLCQLMD 1168
            .|...::|||    ||..|:.:    |:.|||.:.:.:|
pombe  1065 NELNQKLLTL----DWFVPVSQNATFVKQLRNIIQKQID 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBCD	NP_608648.1	TFCD_C	24..>584	CDD:303064	152/586 (26%)
		HEAT repeat	355..383	CDD:293787	10/27 (37%)
		HEAT repeat	393..423	CDD:293787	15/43 (35%)
		TFCD_C	890..1075	CDD:289385	42/215 (20%)
alp1	NP_596393.2	CIN1	13..1105	CDD:227559	291/1274 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	224	1.000	Domainoid score	I532
eggNOG	1	0.900	-	-		E1_COG2116
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I843
OMA	1	1.010	-	-		QHG55142
OrthoFinder	1	1.000	-	-		FOG0004779
OrthoInspector	1	1.000	-	-		oto101936
orthoMCL	1	0.900	-	-		OOG6_102599
Panther	1	1.100	-	-	LDO	PTHR12658
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R52
SonicParanoid	1	1.000	-	-		X3933
TreeFam	1	0.960	-	-
	13	12.860