DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyP and PYGM

DIOPT Version :9

Sequence 1:	NP_001027219.1	Gene:	GlyP / 33386	FlyBaseID:	FBgn0004507	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_005600.1	Gene:	PYGM / 5837	HGNCID:	9726	Length:	842	Species:	Homo sapiens

Alignment Length:	840	Identity:	617/840 - (73%)
Similarity:	726/840 - (86%)	Gaps:	0/840 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKPQSDADRRKQISVRGIAEVGNVTEVKKNFNRHLHYTLVKDRNVSTLRDYYFALANTVKDNMV 65
            ||:|.||.::||||||||:|.|.||||:|||||||||:||||||||:|.||||||||:||:|::|
Human     1 MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLV 65

  Fly    66 GRWIRTQQHYYEKDPKRVYYLSLEYYMGRSLTNTMINLGIQSECEEAMYQLGLDIENLEEMEEDA 130
            |||||||||||||||||:||||||:||||:|.|||:||.:::.|:||.||||||:|.|||:||||
Human    66 GRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDA 130

  Fly   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFAQKIKNGEQVEEPDDWLRYGNPWEKARP 195
            |||||||||||||||||||||||||||||||||:|||.|||..|.|:||.|||||||||||||||
Human   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARP 195

  Fly   196 EFMLPVNFYGRVIDTPEGKKWVDTQRVFAMPYDNPIPGYNNNHVNTLRLWSAKSPIDFNLKFFND 260
            ||.|||:|||.|..|.:|.||||||.|.|||||.|:|||.||.|||:||||||:|.|||||.||.
Human   196 EFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNV 260

  Fly   261 GDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIIRRYKASKFGSREAVRN 325
            |.|||||||||||||||||||||||||||||||||||||:.||||||||||:|:||||.|:.||.
Human   261 GGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRT 325

  Fly   326 TFDHFPDKVAIQLNDTHPSLAIPELMRILVDEEHLTWEKAWDITVRSCAYTNHTVLPEALERWPV 390
            .||.|||||||||||||||||||||||||||.|.:.|:||||:|||:||||||||||||||||||
Human   326 NFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPV 390

  Fly   391 SLLESILPRHLQIIYHINFLHMENVKKKFPDDLDRMRRMSMVEEDGEKRINMAHLSIVGSHAVNG 455
            .|||::|||||||||.||...:..|...||.|:||:||||:|||...||||||||.|.|||||||
Human   391 HLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNG 455

  Fly   456 VAAIHSQILKDSLFHDFYEMEPQKFQNKTNGITPRRWLLLCNPGLSDLIAEKIGDEWPVHLDQLV 520
            ||.|||:|||.::|.||||:||.|||||||||||||||:||||||:::|||:||:::...||||.
Human   456 VARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLR 520

  Fly   521 ALKKWAKDPNFQRNVARVKQENKLKLAAILEKDYGVKINPSSMFDIQVKRIHEYKRQLLNCLHII 585
            .|..:..|..|.|:||:||||||||.||.||::|.|.|||:|:||||||||||||||||||||:|
Human   521 KLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVI 585

  Fly   586 TLYNRIKKDPTANFTPRTIMIGGKAAPGYYVAKQIIKLICAVGNVVNNDPIVGDKLKVIFLENYR 650
            |||||||::|...|.|||:||||||||||::||.||:|:.|:|:|||:||.|||:|:||||||||
Human   586 TLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYR 650

  Fly   651 VTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEMAEEMGLDNIFIFGMT 715
            |:||||::||||||||||||||||||||||||.|||||||||:||||||||||.|.:|.|||||.
Human   651 VSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMR 715

  Fly   716 VDEVEALKKKGYNAYDYYNANPEVKQVIDQIQGGFFSPGNPNEFKNIADILLKYDHYYLLADYDA 780
            |::|:.|.::||||.:||:..||::|||:|:..|||||..|:.||:|.::|:.:|.:.:.|||:.
Human   716 VEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYED 780

  Fly   781 YIKAQDLVSKTYQNQAKWLEMSINNIASSGKFSSDRTIAEYAREIWGVEPTWEKLPAPED 840
            |||.|:.||..|:|..:|..|.|.|||:|||||||||||:||||||||||:.::||||::
Human   781 YIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyP	NP_001027219.1	GT1_Glycogen_Phosphorylase	29..828	CDD:99996	590/798 (74%)
GlyP	NP_001027219.1	P_ylase	32..828	CDD:273967	587/795 (74%)
PYGM	NP_005600.1	GT1_Glycogen_Phosphorylase	29..828	CDD:99996	590/798 (74%)
PYGM	NP_005600.1	P_ylase	32..828	CDD:273967	587/795 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149380
Domainoid	1	1.000	1087	1.000	Domainoid score	I22
eggNOG	1	0.900	-	-		E1_COG0058
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2145
Inparanoid	1	1.050	1286	1.000	Inparanoid score	I164
Isobase	1	0.950	-	0	Normalized mean entropy	S394
OMA	1	1.010	-	-		QHG62832
OrthoDB	1	1.010	-	-		D108256at33208
OrthoFinder	1	1.000	-	-		FOG0000986
OrthoInspector	1	1.000	-	-		otm41957
orthoMCL	1	0.900	-	-		OOG6_100699
Panther	1	1.100	-	-	LDO	PTHR11468
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2230
SonicParanoid	1	1.000	-	-		X645
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750