Protein Alignment Glyp and PYGM

DIOPT Version :10

• Sequence 1: NP_722762.1
• Gene: Glyp / 33386
• FlyBaseID: FBgn0004507
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_005600.1
• Gene: PYGM / 5837
• HGNCID: 9726
• Length: 842
• Species: Homo sapiens
• Alignment Length: 840
• Identity: 617/840 - (73%)
• Similarity: 726/840 - (86%)
• Gaps: 0/840 - (0%)

  Fly     1 MSKPQSDADRRKQISVRGIAEVGNVTEVKKNFNRHLHYTLVKDRNVSTLRDYYFALANTVKDNMV 65
            ||:|.||.::||||||||:|.|.||||:|||||||||:||||||||:|.||||||||:||:|::|
Human     1 MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLV 65

  Fly    66 GRWIRTQQHYYEKDPKRVYYLSLEYYMGRSLTNTMINLGIQSECEEAMYQLGLDIENLEEMEEDA 130
            |||||||||||||||||:||||||:||||:|.|||:||.:::.|:||.||||||:|.|||:||||
Human    66 GRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDA 130

  Fly   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFAQKIKNGEQVEEPDDWLRYGNPWEKARP 195
            |||||||||||||||||||||||||||||||||:|||.|||..|.|:||.|||||||||||||||
Human   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARP 195

  Fly   196 EFMLPVNFYGRVIDTPEGKKWVDTQRVFAMPYDNPIPGYNNNHVNTLRLWSAKSPIDFNLKFFND 260
            ||.|||:|||.|..|.:|.||||||.|.|||||.|:|||.||.|||:||||||:|.|||||.||.
Human   196 EFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNV 260

  Fly   261 GDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIIRRYKASKFGSREAVRN 325
            |.|||||||||||||||||||||||||||||||||||||:.||||||||||:|:||||.|:.||.
Human   261 GGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRT 325

  Fly   326 TFDHFPDKVAIQLNDTHPSLAIPELMRILVDEEHLTWEKAWDITVRSCAYTNHTVLPEALERWPV 390
            .||.|||||||||||||||||||||||||||.|.:.|:||||:|||:||||||||||||||||||
Human   326 NFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPV 390

  Fly   391 SLLESILPRHLQIIYHINFLHMENVKKKFPDDLDRMRRMSMVEEDGEKRINMAHLSIVGSHAVNG 455
            .|||::|||||||||.||...:..|...||.|:||:||||:|||...||||||||.|.|||||||
Human   391 HLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNG 455

  Fly   456 VAAIHSQILKDSLFHDFYEMEPQKFQNKTNGITPRRWLLLCNPGLSDLIAEKIGDEWPVHLDQLV 520
            ||.|||:|||.::|.||||:||.|||||||||||||||:||||||:::|||:||:::...||||.
Human   456 VARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLR 520

  Fly   521 ALKKWAKDPNFQRNVARVKQENKLKLAAILEKDYGVKINPSSMFDIQVKRIHEYKRQLLNCLHII 585
            .|..:..|..|.|:||:||||||||.||.||::|.|.|||:|:||||||||||||||||||||:|
Human   521 KLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVI 585

  Fly   586 TLYNRIKKDPTANFTPRTIMIGGKAAPGYYVAKQIIKLICAVGNVVNNDPIVGDKLKVIFLENYR 650
            |||||||::|...|.|||:||||||||||::||.||:|:.|:|:|||:||.|||:|:||||||||
Human   586 TLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYR 650

  Fly   651 VTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEMAEEMGLDNIFIFGMT 715
            |:||||::||||||||||||||||||||||||.|||||||||:||||||||||.|.:|.|||||.
Human   651 VSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMR 715

  Fly   716 VDEVEALKKKGYNAYDYYNANPEVKQVIDQIQGGFFSPGNPNEFKNIADILLKYDHYYLLADYDA 780
            |::|:.|.::||||.:||:..||::|||:|:..|||||..|:.||:|.::|:.:|.:.:.|||:.
Human   716 VEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYED 780

  Fly   781 YIKAQDLVSKTYQNQAKWLEMSINNIASSGKFSSDRTIAEYAREIWGVEPTWEKLPAPED 840
            |||.|:.||..|:|..:|..|.|.|||:|||||||||||:||||||||||:.::||||::
Human   781 YIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glyp	NP_722762.1	GT35_Glycogen_Phosphorylase	29..828	CDD:340853	590/798 (74%)
PYGM	NP_005600.1	GT35_Glycogen_Phosphorylase	29..828	CDD:340853	590/798 (74%)