Protein Alignment Glyp and PYGL

DIOPT Version :10

• Sequence 1: NP_722762.1
• Gene: Glyp / 33386
• FlyBaseID: FBgn0004507
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_002854.3
• Gene: PYGL / 5836
• HGNCID: 9725
• Length: 847
• Species: Homo sapiens
• Alignment Length: 831
• Identity: 605/831 - (72%)
• Similarity: 705/831 - (84%)
• Gaps: 0/831 - (0%)

  Fly     1 MSKPQSDADRRKQISVRGIAEVGNVTEVKKNFNRHLHYTLVKDRNVSTLRDYYFALANTVKDNMV 65
            |:||.:|.::|:|||:|||..|.||.|:||:||||||:||||||||:|.||||||||:||:|::|
Human     1 MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLV 65

  Fly    66 GRWIRTQQHYYEKDPKRVYYLSLEYYMGRSLTNTMINLGIQSECEEAMYQLGLDIENLEEMEEDA 130
            |||||||||||:|.||||||||||:||||:|.|||||||:|:.|:||:||||||||.|||:||||
Human    66 GRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDA 130

  Fly   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFAQKIKNGEQVEEPDDWLRYGNPWEKARP 195
            |||||||||||||||||||||||||||||||||||||.|||::|.||||.||||||||||||:||
Human   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRP 195

  Fly   196 EFMLPVNFYGRVIDTPEGKKWVDTQRVFAMPYDNPIPGYNNNHVNTLRLWSAKSPIDFNLKFFND 260
            ||||||:|||:|..|..|.||:|||.|.|:|||.|:|||.||.|||:|||||::|.||||:.||.
Human   196 EFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNV 260

  Fly   261 GDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIIRRYKASKFGSREAVRN 325
            |||||||||||||||||||||||||||||||||||||||:.||||||||||:|||||||......
Human   261 GDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGT 325

  Fly   326 TFDHFPDKVAIQLNDTHPSLAIPELMRILVDEEHLTWEKAWDITVRSCAYTNHTVLPEALERWPV 390
            .||.|||:||||||||||:|||||||||.||.|.|.|.|||::|.::.|||||||||||||||||
Human   326 VFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPV 390

  Fly   391 SLLESILPRHLQIIYHINFLHMENVKKKFPDDLDRMRRMSMVEEDGEKRINMAHLSIVGSHAVNG 455
            .|:|.:|||||:|||.||..|::.:...||.|:||:||||::||:|.||||||||.|||||||||
Human   391 DLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNG 455

  Fly   456 VAAIHSQILKDSLFHDFYEMEPQKFQNKTNGITPRRWLLLCNPGLSDLIAEKIGDEWPVHLDQLV 520
            ||.|||.|:|..:|.||.|:||.||||||||||||||||||||||::|||||||:::...|.||.
Human   456 VAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLT 520

  Fly   521 ALKKWAKDPNFQRNVARVKQENKLKLAAILEKDYGVKINPSSMFDIQVKRIHEYKRQLLNCLHII 585
            .|..:..|..|.|.:|:||||||||.:..||.:|.||||||||||:|||||||||||||||||:|
Human   521 KLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVI 585

  Fly   586 TLYNRIKKDPTANFTPRTIMIGGKAAPGYYVAKQIIKLICAVGNVVNNDPIVGDKLKVIFLENYR 650
            |:||||||||...|.|||::|||||||||::||.|||||.:|.:||||||:||.|||||||||||
Human   586 TMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYR 650

  Fly   651 VTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEMAEEMGLDNIFIFGMT 715
            |:||||::||.|||||||||||||||||||||.|||||||||:||||||||||.|.:|:|||||.
Human   651 VSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMR 715

  Fly   716 VDEVEALKKKGYNAYDYYNANPEVKQVIDQIQGGFFSPGNPNEFKNIADILLKYDHYYLLADYDA 780
            :|:|.||.||||.|.:||.|.||:|.|||||..|||||..|:.||:|.::|..:|.:.:.|||:|
Human   716 IDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA 780

  Fly   781 YIKAQDLVSKTYQNQAKWLEMSINNIASSGKFSSDRTIAEYAREIWGVEPT 831
            |:|.||.||:.|.|...|..|.:.|||:||||||||||.|||:.||.|||:
Human   781 YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPS 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glyp	NP_722762.1	GT35_Glycogen_Phosphorylase	29..828	CDD:340853	587/798 (74%)
PYGL	NP_002854.3	GT35_Glycogen_Phosphorylase	29..828	CDD:340853	587/798 (74%)