DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyP and pygb

DIOPT Version :9

Sequence 1:	NP_001027219.1	Gene:	GlyP / 33386	FlyBaseID:	FBgn0004507	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_997974.2	Gene:	pygb / 403051	ZFINID:	ZDB-GENE-040928-2	Length:	843	Species:	Danio rerio

Alignment Length:	840	Identity:	613/840 - (72%)
Similarity:	723/840 - (86%)	Gaps:	0/840 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKPQSDADRRKQISVRGIAEVGNVTEVKKNFNRHLHYTLVKDRNVSTLRDYYFALANTVKDNMV 65
            ||||.:|.:|||||||||||.:|:|.|:||:||||||:||||||||:|.||||||||:||:|::|
Zfish     1 MSKPLTDHERRKQISVRGIAGLGDVAEIKKSFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLV 65

  Fly    66 GRWIRTQQHYYEKDPKRVYYLSLEYYMGRSLTNTMINLGIQSECEEAMYQLGLDIENLEEMEEDA 130
            ||||||||:||||||||::|||||:||||:|.|||||||:|:.|:||:||||||:|.|||:||||
Zfish    66 GRWIRTQQYYYEKDPKRIHYLSLEFYMGRTLQNTMINLGLQNTCDEAIYQLGLDLEELEEIEEDA 130

  Fly   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFAQKIKNGEQVEEPDDWLRYGNPWEKARP 195
            |||||||||||||||||||:|||||||||||||:|||.|||.:|.|:||.|||||||||||||||
Zfish   131 GLGNGGLGRLAACFLDSMASLGLAAYGYGIRYEFGIFNQKIAHGWQIEEADDWLRYGNPWEKARP 195

  Fly   196 EFMLPVNFYGRVIDTPEGKKWVDTQRVFAMPYDNPIPGYNNNHVNTLRLWSAKSPIDFNLKFFND 260
            |:||||:|||||..|.:|.||||||.|.|||||.|:|||.||.|||:||||||:|.||||:.||.
Zfish   196 EYMLPVHFYGRVEHTHDGPKWVDTQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFNLQEFNV 260

  Fly   261 GDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIIRRYKASKFGSREAVRN 325
            |||||||||||||||||||||||||||||||||||||||:.||||||||||:|:||||.|:.||.
Zfish   261 GDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRT 325

  Fly   326 TFDHFPDKVAIQLNDTHPSLAIPELMRILVDEEHLTWEKAWDITVRSCAYTNHTVLPEALERWPV 390
            :|:.|.:|||||||||||:||||||||||||.|||.|||||:||.::||||||||||||||||||
Zfish   326 SFETFHEKVAIQLNDTHPALAIPELMRILVDIEHLDWEKAWEITTKTCAYTNHTVLPEALERWPV 390

  Fly   391 SLLESILPRHLQIIYHINFLHMENVKKKFPDDLDRMRRMSMVEEDGEKRINMAHLSIVGSHAVNG 455
            .:.|.:|||||||:|.||..|::.:...:|.|.||:||||::||...||||||||.:||||||||
Zfish   391 YMFEKLLPRHLQIVYEINRRHLDRISALYPGDTDRLRRMSLIEEGDPKRINMAHLCVVGSHAVNG 455

  Fly   456 VAAIHSQILKDSLFHDFYEMEPQKFQNKTNGITPRRWLLLCNPGLSDLIAEKIGDEWPVHLDQLV 520
            ||.|||.|:|.::|.||.::||:||||||||||||||||||||||:|:||||||:::...|.||.
Zfish   456 VARIHSDIVKTTVFKDFCDIEPEKFQNKTNGITPRRWLLLCNPGLADIIAEKIGEDFLTDLFQLR 520

  Fly   521 ALKKWAKDPNFQRNVARVKQENKLKLAAILEKDYGVKINPSSMFDIQVKRIHEYKRQLLNCLHII 585
            .|..:..|..|.|:||:||||||.|.||.||.:|.|||||.|:||||||||||||||||||||||
Zfish   521 KLLDFINDEMFIRDVAKVKQENKQKFAAYLENEYNVKINPESIFDIQVKRIHEYKRQLLNCLHII 585

  Fly   586 TLYNRIKKDPTANFTPRTIMIGGKAAPGYYVAKQIIKLICAVGNVVNNDPIVGDKLKVIFLENYR 650
            ||||||||:|...|.|||:||||||||||::||.|||||.:||.|||:||:|||:||||||||||
Zfish   586 TLYNRIKKEPNKKFVPRTVMIGGKAAPGYHMAKMIIKLITSVGEVVNHDPVVGDRLKVIFLENYR 650

  Fly   651 VTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEMAEEMGLDNIFIFGMT 715
            |:||||::||||||||||||||||||||||||.|||||||||:||||||||||.|.:|:|||||.
Zfish   651 VSLAEKVVPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMR 715

  Fly   716 VDEVEALKKKGYNAYDYYNANPEVKQVIDQIQGGFFSPGNPNEFKNIADILLKYDHYYLLADYDA 780
            |.:||.:.||||||.:||...||:|.|:|||..|||||..|..||::.::|:.:|.:.:.|||::
Zfish   716 VQDVEDMDKKGYNAREYYERLPELKLVMDQISTGFFSPKEPELFKDVVNMLMDHDRFKVFADYES 780

  Fly   781 YIKAQDLVSKTYQNQAKWLEMSINNIASSGKFSSDRTIAEYAREIWGVEPTWEKLPAPED 840
            ||..||.|::.|:|..:|.:..|.|||:||||||||||||||||||||||:..|:|.|.:
Zfish   781 YISCQDKVNELYKNPKEWTKKVIRNIAASGKFSSDRTIAEYAREIWGVEPSDVKIPPPNE 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyP	NP_001027219.1	GT1_Glycogen_Phosphorylase	29..828	CDD:99996	587/798 (74%)
GlyP	NP_001027219.1	P_ylase	32..828	CDD:273967	585/795 (74%)
pygb	NP_997974.2	GT1_Glycogen_Phosphorylase	29..828	CDD:99996	587/798 (74%)
pygb	NP_997974.2	P_ylase	32..828	CDD:273967	585/795 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583559
Domainoid	1	1.000	1088	1.000	Domainoid score	I21
eggNOG	1	0.900	-	-		E1_COG0058
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1294	1.000	Inparanoid score	I157
OMA	1	1.010	-	-		QHG62832
OrthoDB	1	1.010	-	-		D108256at33208
OrthoFinder	1	1.000	-	-		FOG0000986
OrthoInspector	1	1.000	-	-		otm26449
orthoMCL	1	0.900	-	-		OOG6_100699
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X645
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.670