DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GlyP and pygmb

DIOPT Version :9

Sequence 1:	NP_001027219.1	Gene:	GlyP / 33386	FlyBaseID:	FBgn0004507	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001314960.1	Gene:	pygmb / 393444	ZFINID:	ZDB-GENE-040426-1206	Length:	842	Species:	Danio rerio

Alignment Length:	840	Identity:	609/840 - (72%)
Similarity:	727/840 - (86%)	Gaps:	0/840 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKPQSDADRRKQISVRGIAEVGNVTEVKKNFNRHLHYTLVKDRNVSTLRDYYFALANTVKDNMV 65
            ||||.:|.::||||||||:|.|.||.::|.|||||||:||||||||:|.||||||||:||:|::|
Zfish     1 MSKPLTDQEKRKQISVRGLAGVENVADLKTNFNRHLHFTLVKDRNVATKRDYYFALAHTVRDHLV 65

  Fly    66 GRWIRTQQHYYEKDPKRVYYLSLEYYMGRSLTNTMINLGIQSECEEAMYQLGLDIENLEEMEEDA 130
            ||||||||||||||||||||||||:||||:|.|||:||.:::.|:||:||||||:|.|:::||||
Zfish    66 GRWIRTQQHYYEKDPKRVYYLSLEFYMGRTLQNTMVNLALENACDEAIYQLGLDMEELQDIEEDA 130

  Fly   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFAQKIKNGEQVEEPDDWLRYGNPWEKARP 195
            |||||||||||||||||||||||||||||||||:|||.|||..|.||||.|||||||||||||||
Zfish   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVKGWQVEEADDWLRYGNPWEKARP 195

  Fly   196 EFMLPVNFYGRVIDTPEGKKWVDTQRVFAMPYDNPIPGYNNNHVNTLRLWSAKSPIDFNLKFFND 260
            |:|.||:|||||...|:|.||||||.|.|:|||.|:|||.||.|||:||||||:|.:|:||.||.
Zfish   196 EYMRPVHFYGRVEHHPDGVKWVDTQVVLALPYDTPVPGYRNNIVNTMRLWSAKAPCEFHLKDFNV 260

  Fly   261 GDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIIRRYKASKFGSREAVRN 325
            |.|||||||:|||||||||||||||||||||||||||||:.||||||||||:|||||||.|.||.
Zfish   261 GGYIQAVLDKNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTEIVRM 325

  Fly   326 TFDHFPDKVAIQLNDTHPSLAIPELMRILVDEEHLTWEKAWDITVRSCAYTNHTVLPEALERWPV 390
            .....|||||||||||||::|||||||||||:|.|||:.|||||||:||||||||||||||||||
Zfish   326 DLSTLPDKVAIQLNDTHPAMAIPELMRILVDDEKLTWDVAWDITVRTCAYTNHTVLPEALERWPV 390

  Fly   391 SLLESILPRHLQIIYHINFLHMENVKKKFPDDLDRMRRMSMVEEDGEKRINMAHLSIVGSHAVNG 455
            .|.:::|||||:|||.||..|||.:...:|.|.||:||||::||.|:|:||||||.|||||||||
Zfish   391 DLFQNLLPRHLEIIYEINRRHMERISALYPGDFDRLRRMSLIEEGGQKKINMAHLCIVGSHAVNG 455

  Fly   456 VAAIHSQILKDSLFHDFYEMEPQKFQNKTNGITPRRWLLLCNPGLSDLIAEKIGDEWPVHLDQLV 520
            ||.|||.|:||::|.|||:::|||||||||||||||||::|||||:::|||:||:::...|.||.
Zfish   456 VAQIHSDIIKDTVFKDFYDVDPQKFQNKTNGITPRRWLVMCNPGLAEVIAERIGEDYIRDLSQLK 520

  Fly   521 ALKKWAKDPNFQRNVARVKQENKLKLAAILEKDYGVKINPSSMFDIQVKRIHEYKRQLLNCLHII 585
            .|.|:..|....|::|:||||||:|.|..||:.|.|||||:||||:.||||||||||||||||||
Zfish   521 KLLKFVDDDALIRDIAKVKQENKMKFAVHLEEQYKVKINPNSMFDVHVKRIHEYKRQLLNCLHII 585

  Fly   586 TLYNRIKKDPTANFTPRTIMIGGKAAPGYYVAKQIIKLICAVGNVVNNDPIVGDKLKVIFLENYR 650
            ||||||||:|...:|||||||||||||||:.||.|||||.::|:|||||.:|||:||||||||||
Zfish   586 TLYNRIKKEPNKAWTPRTIMIGGKAAPGYHTAKMIIKLITSIGDVVNNDIVVGDRLKVIFLENYR 650

  Fly   651 VTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEMAEEMGLDNIFIFGMT 715
            ||||||::||||||||||||||||||||||||.|||||||||:||||||||||.|.:|:|||||.
Zfish   651 VTLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMR 715

  Fly   716 VDEVEALKKKGYNAYDYYNANPEVKQVIDQIQGGFFSPGNPNEFKNIADILLKYDHYYLLADYDA 780
            |.:|||:.||||:|.:|||..||:||.:|||.||:|||.:|::||:|.::|:.:|.:.:.|||:.
Zfish   716 VKDVEAMDKKGYDAMEYYNRIPELKQAMDQISGGYFSPADPDQFKDIVNMLMHHDRFKVFADYED 780

  Fly   781 YIKAQDLVSKTYQNQAKWLEMSINNIASSGKFSSDRTIAEYAREIWGVEPTWEKLPAPED 840
            ||:.||.||..|:|..:|.:|.|:|||..|||||||||::|||||||:||:.||:.||:|
Zfish   781 YIQCQDKVSALYKNTKEWTKMVIHNIAGCGKFSSDRTISQYAREIWGMEPSLEKIAAPDD 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyP	NP_001027219.1	GT1_Glycogen_Phosphorylase	29..828	CDD:99996	584/798 (73%)
GlyP	NP_001027219.1	P_ylase	32..828	CDD:273967	582/795 (73%)
pygmb	NP_001314960.1	GT1_Glycogen_Phosphorylase	29..827	CDD:99996	583/797 (73%)
pygmb	NP_001314960.1	P_ylase	32..827	CDD:273967	581/794 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583561
Domainoid	1	1.000	1088	1.000	Domainoid score	I21
eggNOG	1	0.900	-	-		E1_COG0058
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1294	1.000	Inparanoid score	I157
OMA	1	1.010	-	-		QHG62832
OrthoDB	1	1.010	-	-		D108256at33208
OrthoFinder	1	1.000	-	-		FOG0000986
OrthoInspector	1	1.000	-	-		otm26449
orthoMCL	1	0.900	-	-		OOG6_100699
Panther	1	1.100	-	-	LDO	PTHR11468
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2230
SonicParanoid	1	1.000	-	-		X645
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800