DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyP and Pygm

DIOPT Version :9

Sequence 1:	NP_001027219.1	Gene:	GlyP / 33386	FlyBaseID:	FBgn0004507	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_036770.1	Gene:	Pygm / 24701	RGDID:	3461	Length:	842	Species:	Rattus norvegicus

Alignment Length:	841	Identity:	620/841 - (73%)
Similarity:	728/841 - (86%)	Gaps:	0/841 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKPQSDADRRKQISVRGIAEVGNVTEVKKNFNRHLHYTLVKDRNVSTLRDYYFALANTVKDNMV 65
            ||:|.||.|:||||||||:|.|.||:::|||||||||:||||||||:|.||||||||:||:|::|
  Rat     1 MSRPLSDQDKRKQISVRGLAGVENVSDLKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLV 65

  Fly    66 GRWIRTQQHYYEKDPKRVYYLSLEYYMGRSLTNTMINLGIQSECEEAMYQLGLDIENLEEMEEDA 130
            |||||||||||||||||:||||||:||||:|.|||:||.:::.|:||.||||||:|.|||:||||
  Rat    66 GRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDA 130

  Fly   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFAQKIKNGEQVEEPDDWLRYGNPWEKARP 195
            |||||||||||||||||||||||||||||||||:|||.|||..|.|:||.|||||||||||||||
  Rat   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARP 195

  Fly   196 EFMLPVNFYGRVIDTPEGKKWVDTQRVFAMPYDNPIPGYNNNHVNTLRLWSAKSPIDFNLKFFND 260
            ||.|||:|||||..|.:|.||||||.|.|||||.|:|||.||.|||:||||||:|.|||||.||.
  Rat   196 EFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNV 260

  Fly   261 GDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIIRRYKASKFGSREAVRN 325
            |.|||||||||||||||||||||||||||||||||||||:.||||||||||:|:||||.|:.||.
  Rat   261 GGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRT 325

  Fly   326 TFDHFPDKVAIQLNDTHPSLAIPELMRILVDEEHLTWEKAWDITVRSCAYTNHTVLPEALERWPV 390
            .||.|||||||||||||||||||||||||||.|.|.|:||||:||::||||||||||||||||||
  Rat   326 NFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPV 390

  Fly   391 SLLESILPRHLQIIYHINFLHMENVKKKFPDDLDRMRRMSMVEEDGEKRINMAHLSIVGSHAVNG 455
            .|:|::|||||||||.||...:..|...||.|:||:||||:|||...||||||||.|.|||||||
  Rat   391 HLMETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNG 455

  Fly   456 VAAIHSQILKDSLFHDFYEMEPQKFQNKTNGITPRRWLLLCNPGLSDLIAEKIGDEWPVHLDQLV 520
            ||.|||:|||.::|.||||:||.|||||||||||||||:||||||:::|||:||:|:...||||.
  Rat   456 VARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEEYISDLDQLR 520

  Fly   521 ALKKWAKDPNFQRNVARVKQENKLKLAAILEKDYGVKINPSSMFDIQVKRIHEYKRQLLNCLHII 585
            .|..:..|..|.|:||:||||||||.:|.||::|.|.|||:|:||:|||||||||||||||||||
  Rat   521 KLLSYVDDEAFIRDVAKVKQENKLKFSAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHII 585

  Fly   586 TLYNRIKKDPTANFTPRTIMIGGKAAPGYYVAKQIIKLICAVGNVVNNDPIVGDKLKVIFLENYR 650
            |||||||::|.....||||||||||||||::||.|||||.|:|:|||:||.|||:|:||||||||
  Rat   586 TLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPAVGDRLRVIFLENYR 650

  Fly   651 VTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEMAEEMGLDNIFIFGMT 715
            |:||||::||||||||||||||||||||||||.|||||||||:||||||||||.|.||.|||||.
  Rat   651 VSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEDNFFIFGMR 715

  Fly   716 VDEVEALKKKGYNAYDYYNANPEVKQVIDQIQGGFFSPGNPNEFKNIADILLKYDHYYLLADYDA 780
            |::||.|.::||||.:||:..||::|:|:|:..|||||..|:.||:|.::|:.:|.:.:.|||:.
  Rat   716 VEDVERLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE 780

  Fly   781 YIKAQDLVSKTYQNQAKWLEMSINNIASSGKFSSDRTIAEYAREIWGVEPTWEKLPAPEDQ 841
            |||.||.||:.|:|..:|..|.|.|||:|||||||||||:||||||||||:.::||||:::
  Rat   781 YIKCQDKVSELYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEK 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyP	NP_001027219.1	GT1_Glycogen_Phosphorylase	29..828	CDD:99996	594/798 (74%)
GlyP	NP_001027219.1	P_ylase	32..828	CDD:273967	591/795 (74%)
Pygm	NP_036770.1	GT35_Glycogen_Phosphorylase	29..828	CDD:340853	594/798 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343255
Domainoid	1	1.000	1081	1.000	Domainoid score	I21
eggNOG	1	0.900	-	-		E1_COG0058
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2145
Inparanoid	1	1.050	1270	1.000	Inparanoid score	I154
OMA	1	1.010	-	-		QHG62832
OrthoDB	1	1.010	-	-		D108256at33208
OrthoFinder	1	1.000	-	-		FOG0000986
OrthoInspector	1	1.000	-	-		otm46097
orthoMCL	1	0.900	-	-		OOG6_100699
Panther	1	1.100	-	-	LDO	PTHR11468
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X645
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770