DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyP and pygl-1

DIOPT Version :9

Sequence 1:	NP_001027219.1	Gene:	GlyP / 33386	FlyBaseID:	FBgn0004507	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_504007.1	Gene:	pygl-1 / 178777	WormBaseID:	WBGene00020696	Length:	882	Species:	Caenorhabditis elegans

Alignment Length:	842	Identity:	576/842 - (68%)
Similarity:	714/842 - (84%)	Gaps:	3/842 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SDADRRKQISVRGIAEVGNVTEVKKNFNRHLHYTLVKDRNVSTLRDYYFALANTVKDNMVGRWIR 70
            :|.||||||||||||:|.||:.:||.||||||::::|||||:|.|||||||||||:|::|.||||
Worm    40 NDHDRRKQISVRGIAQVENVSNIKKAFNRHLHFSIIKDRNVATDRDYYFALANTVRDHLVSRWIR 104

  Fly    71 TQQHYYEKDPKRVYYLSLEYYMGRSLTNTMINLGIQSECEEAMYQLGLDIENLEEMEEDAGLGNG 135
            ||||||:||||||||||||:||||:|:|||:|||||:..:||:||||||||.|:|:|||||||||
Worm   105 TQQHYYDKDPKRVYYLSLEFYMGRTLSNTMMNLGIQATVDEALYQLGLDIEELQEIEEDAGLGNG 169

  Fly   136 GLGRLAACFLDSMATLGLAAYGYGIRYEYGIFAQKIKNGEQVEEPDDWLRYGNPWEKARPEFMLP 200
            |||||||||||||||||:.|||||:|||||||.|.|::|.|:||||||||:||||||||||:|||
Worm   170 GLGRLAACFLDSMATLGIPAYGYGLRYEYGIFKQLIRDGWQIEEPDDWLRFGNPWEKARPEYMLP 234

  Fly   201 VNFYGRVIDTPEGKKWVDTQRVFAMPYDNPIPGYNNNHVNTLRLWSAKSPIDFNLKFFNDGDYIQ 265
            |||||:|:......||:|||.|||||||.|:|||.||.||||||||||:...|:|||||||||:|
Worm   235 VNFYGKVVKEDGKSKWIDTQVVFAMPYDTPVPGYKNNIVNTLRLWSAKAENHFHLKFFNDGDYVQ 299

  Fly   266 AVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIIRRYKASKFGSREAVRNTFDHF 330
            ||:||||:|||:||||||||.|.||||||||:||:.||||||||||:|:|.:|:|||||..|:.|
Worm   300 AVMDRNLSENITRVLYPNDNMFLGKELRLKQQYFLVAATLQDIIRRFKSSIYGNREAVRVNFETF 364

  Fly   331 PDKVAIQLNDTHPSLAIPELMRILVDEEHLTWEKAWDITVRSCAYTNHTVLPEALERWPVSLLES 395
            ||||||||||||||:.||||:|:|:|.|.|||::||||.:::.||||||:||||||||||||:::
Worm   365 PDKVAIQLNDTHPSIGIPELIRLLIDVEGLTWDQAWDICIKTYAYTNHTLLPEALERWPVSLMQN 429

  Fly   396 ILPRHLQIIYHINFLHMENVKKKFPDDLDRMRRMSMVEED---GEKRINMAHLSIVGSHAVNGVA 457
            :|||||:|||.||...|..:.::||.|.|||||||:|||.   ||||||||||.||.|||:||||
Worm   430 LLPRHLEIIYEINQKFMNTISQRFPGDFDRMRRMSIVEEADQFGEKRINMAHLCIVASHAINGVA 494

  Fly   458 AIHSQILKDSLFHDFYEMEPQKFQNKTNGITPRRWLLLCNPGLSDLIAEKIGDEWPVHLDQLVAL 522
            |:||.:||.|.|.||||..|.:||||||||||||||||.||.|:|||.||||:.|..:||:|..|
Worm   495 ALHSDLLKSSTFRDFYEFYPDRFQNKTNGITPRRWLLLSNPSLADLIVEKIGESWITNLDELQKL 559

  Fly   523 KKWAKDPNFQRNVARVKQENKLKLAAILEKDYGVKINPSSMFDIQVKRIHEYKRQLLNCLHIITL 587
            |::|.|..|..::.|||.|||.::|..|..:|.|.:|.:|:||:.|||||||||||||.||:|.|
Worm   560 KEYANDAGFLDSIRRVKLENKQQVAQYLSDEYNVNVNAASLFDVHVKRIHEYKRQLLNILHVIAL 624

  Fly   588 YNRIKKDPTANFTPRTIMIGGKAAPGYYVAKQIIKLICAVGNVVNNDPIVGDKLKVIFLENYRVT 652
            |||||::|..:...||::.||||||||::|||||:||.||...||||.||||:|||||||||||:
Worm   625 YNRIKENPNIDMVKRTVLYGGKAAPGYHMAKQIIRLITAVAEQVNNDAIVGDRLKVIFLENYRVS 689

  Fly   653 LAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEMAEEMGLDNIFIFGMTVD 717
            :||||:||:|||||||||||||||||||||.||||||||||||||||||||||.:|||||||.|:
Worm   690 MAEKIIPASDLSEQISTAGTEASGTGNMKFMLNGALTIGTLDGANVEMAEEMGDENIFIFGMNVE 754

  Fly   718 EVEALKKKGYNAYDYYNANPEVKQVIDQIQGGFFSPGNPNEFKNIADILLKYDHYYLLADYDAYI 782
            |||||.|:||::.::.:.:|.:||:|:||:||.|:|.:|::.|:::::|..:|.:.:.||:||:|
Worm   755 EVEALTKRGYSSQEFIDKSPMLKQIIEQIEGGMFTPEDPDQLKDLSNMLRYHDRFMVCADFDAFI 819

  Fly   783 KAQDLVSKTYQNQAKWLEMSINNIASSGKFSSDRTIAEYAREIWGVEPTWEKLPAPEDQPQN 844
            :|||.||.|:::|.||..|::.||||:||||:||||.||||||||::.....||||.:..::
Worm   820 EAQDKVSATFRDQEKWSRMALYNIASTGKFSTDRTITEYAREIWGIDQFESSLPAPYENEKS 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyP	NP_001027219.1	GT1_Glycogen_Phosphorylase	29..828	CDD:99996	555/801 (69%)
GlyP	NP_001027219.1	P_ylase	32..828	CDD:273967	553/798 (69%)
pygl-1	NP_504007.1	GT1_Glycogen_Phosphorylase	63..865	CDD:99996	555/801 (69%)
pygl-1	NP_504007.1	P_ylase	66..865	CDD:273967	553/798 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160742
Domainoid	1	1.000	1024	1.000	Domainoid score	I7
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2145
Inparanoid	1	1.050	1213	1.000	Inparanoid score	I93
Isobase	1	0.950	-	0	Normalized mean entropy	S394
OMA	1	1.010	-	-		QHG62832
OrthoDB	1	1.010	-	-		D108256at33208
OrthoFinder	1	1.000	-	-		FOG0000986
OrthoInspector	1	1.000	-	-		oto20690
orthoMCL	1	0.900	-	-		OOG6_100699
Panther	1	1.100	-	-	LDO	PTHR11468
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X645
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.860