DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyP and Pygl

DIOPT Version :9

Sequence 1:	NP_001027219.1	Gene:	GlyP / 33386	FlyBaseID:	FBgn0004507	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_573461.2	Gene:	Pygl / 110095	MGIID:	97829	Length:	850	Species:	Mus musculus

Alignment Length:	831	Identity:	606/831 - (72%)
Similarity:	705/831 - (84%)	Gaps:	0/831 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKPQSDADRRKQISVRGIAEVGNVTEVKKNFNRHLHYTLVKDRNVSTLRDYYFALANTVKDNMV 65
            |:||.:|.::|:|||:|||..|.||.|:||.||||||:||||||||:|.||||||||:||:|::|
Mouse     1 MAKPLTDQEKRRQISIRGIVGVENVAELKKGFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLV 65

  Fly    66 GRWIRTQQHYYEKDPKRVYYLSLEYYMGRSLTNTMINLGIQSECEEAMYQLGLDIENLEEMEEDA 130
            |||||||||||:|.||||||||||:||||:|.|||||||:|:.|:||:||||||:|.|||:||||
Mouse    66 GRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDMEELEEIEEDA 130

  Fly   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFAQKIKNGEQVEEPDDWLRYGNPWEKARP 195
            |||||||||||||||||||||||||||||||||||||.|||:.|.||||.|||||:|||||||||
Mouse   131 GLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIREGWQVEEADDWLRHGNPWEKARP 195

  Fly   196 EFMLPVNFYGRVIDTPEGKKWVDTQRVFAMPYDNPIPGYNNNHVNTLRLWSAKSPIDFNLKFFND 260
            ||||||:|||||..|..|.||||||.|.|:|||.|:|||.||.|||:|||||::|.||||:.||.
Mouse   196 EFMLPVHFYGRVEHTQTGTKWVDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLQDFNV 260

  Fly   261 GDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIIRRYKASKFGSREAVRN 325
            |||||||||||||||||||||||||||||||||||||||:.||||||:|||:|||||||::.:..
Mouse   261 GDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDVIRRFKASKFGSKDGMGT 325

  Fly   326 TFDHFPDKVAIQLNDTHPSLAIPELMRILVDEEHLTWEKAWDITVRSCAYTNHTVLPEALERWPV 390
            .||.|||:||||||||||:|||||||||.||.|.|.|.|||:||.::.|||||||||||||||||
Mouse   326 VFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWAKAWEITKKTFAYTNHTVLPEALERWPV 390

  Fly   391 SLLESILPRHLQIIYHINFLHMENVKKKFPDDLDRMRRMSMVEEDGEKRINMAHLSIVGSHAVNG 455
            .|:|.:|||||:|||.||..|::.:...||.|:.||||||::||:|.||||||||.|||.|||||
Mouse   391 ELVEKLLPRHLEIIYEINQKHLDRIVALFPKDISRMRRMSLIEEEGGKRINMAHLCIVGCHAVNG 455

  Fly   456 VAAIHSQILKDSLFHDFYEMEPQKFQNKTNGITPRRWLLLCNPGLSDLIAEKIGDEWPVHLDQLV 520
            ||.|||.|:|..:|.||.|:||.||||||||||||||||||||||:||||||||:::...|.||.
Mouse   456 VAKIHSDIVKTQVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLADLIAEKIGEDYVKDLSQLT 520

  Fly   521 ALKKWAKDPNFQRNVARVKQENKLKLAAILEKDYGVKINPSSMFDIQVKRIHEYKRQLLNCLHII 585
            .|..:..|..|.|.:|:||||||||.:..|||:|.||||||||||:.||||||||||||||||:|
Mouse   521 KLHSFVSDDIFLREIAKVKQENKLKFSQFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVI 585

  Fly   586 TLYNRIKKDPTANFTPRTIMIGGKAAPGYYVAKQIIKLICAVGNVVNNDPIVGDKLKVIFLENYR 650
            |:||||||||...|.|||::|||||||||::||.|||||.:|..||||||:||.|||||||||||
Mouse   586 TMYNRIKKDPKKFFVPRTVIIGGKAAPGYHMAKMIIKLITSVAEVVNNDPMVGSKLKVIFLENYR 650

  Fly   651 VTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEMAEEMGLDNIFIFGMT 715
            |:||||::||.|||||||||||||||||||||.|||||||||:||||||||||.|.:|:|||||.
Mouse   651 VSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMR 715

  Fly   716 VDEVEALKKKGYNAYDYYNANPEVKQVIDQIQGGFFSPGNPNEFKNIADILLKYDHYYLLADYDA 780
            ||:|.||.||||.|.:||.|.||:|.|||||..|||||..|:.||:|.::|..:|.:.:.|||:|
Mouse   716 VDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPNQPDLFKDIINMLFYHDRFKVFADYEA 780

  Fly   781 YIKAQDLVSKTYQNQAKWLEMSINNIASSGKFSSDRTIAEYAREIWGVEPT 831
            |:|.|:.||:.|.||..|..|.:.|||:||||||||||.|||::||.:||:
Mouse   781 YVKCQEKVSQLYMNQKAWNTMVLKNIAASGKFSSDRTIKEYAKDIWNMEPS 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyP	NP_001027219.1	GT1_Glycogen_Phosphorylase	29..828	CDD:99996	589/798 (74%)
GlyP	NP_001027219.1	P_ylase	32..828	CDD:273967	587/795 (74%)
Pygl	NP_573461.2	GT1_Glycogen_Phosphorylase	29..827	CDD:99996	588/797 (74%)
Pygl	NP_573461.2	P_ylase	32..827	CDD:273967	586/794 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839438
Domainoid	1	1.000	1085	1.000	Domainoid score	I22
eggNOG	1	0.900	-	-		E1_COG0058
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1289	1.000	Inparanoid score	I162
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62832
OrthoDB	1	1.010	-	-		D108256at33208
OrthoFinder	1	1.000	-	-		FOG0000986
OrthoInspector	1	1.000	-	-		otm44006
orthoMCL	1	0.900	-	-		OOG6_100699
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2230
SonicParanoid	1	1.000	-	-		X645
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.700