DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4259 and tmprss2

DIOPT Version :9

Sequence 1:	NP_001259904.1	Gene:	CG4259 / 33385	FlyBaseID:	FBgn0031389	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_001008623.1	Gene:	tmprss2 / 494080	ZFINID:	ZDB-GENE-041212-48	Length:	486	Species:	Danio rerio

Alignment Length:	244	Identity:	73/244 - (29%)
Similarity:	113/244 - (46%)	Gaps:	38/244 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RATFPWVVSVLDQRDWLFRYIGVGSLINPNVVLTAAHILN------GTTKYDLVVRAGEWDTSTT 94
            :..:||.||:    .:..|::..||:|.|..:|||||.::      |.|.|     ||....|..
Zfish   261 KGVWPWQVSL----HYSGRHLCGGSIITPYWILTAAHCVHQFSNPGGWTVY-----AGYLTQSEM 316

  Fly    95 ADQQHVDLEVLNIVSHEQFNRFNAENNMALLILVSAFEMTANINLIPLYLQEAGIQ---KGSCFF 156
            |...  ...|..||.|: ||....||::||:.|.:|  :|.:.|:.|:.|...|:.   :..|:.
Zfish   317 ASAS--GNSVNRIVIHD-FNPNTNENDIALMRLNTA--LTISTNIRPVCLPNKGMSFTAQQDCYV 376

  Fly   157 NGWGKVYLNSTDYPTVLKTVQVDLLSMGMCSSRKLPI-------QQIC-GKGLEGID-CSGDGGA 212
            .|||.::...:...| |:..::.|:...:|:||  |:       ..|| ||...|:| |.||.|.
Zfish   377 TGWGALFSGGSSSAT-LQEAKIQLIDSTICNSR--PVYNGLITDTMICAGKLAGGVDSCQGDSGG 438

  Fly   213 PLVCRILTYPYKYAQVGIVNWLSQKPVENTFIVFTNVAGLLPWIDYHLR 261
            |||..:.:.   :..:|..:|.....|.|...|:.||...|.||...:|
Zfish   439 PLVTNVRSL---WWLLGDTSWGDGCAVRNKPGVYGNVTYFLDWIYQQMR 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4259	NP_001259904.1	Tryp_SPc	39..259	CDD:238113	72/237 (30%)
CG4259	NP_001259904.1	Tryp_SPc	39..256	CDD:214473	70/234 (30%)
tmprss2	NP_001008623.1	LDLa	132..168	CDD:238060
		SRCR_2	173..248	CDD:295335
		Tryp_SPc	251..479	CDD:214473	70/237 (30%)
		Tryp_SPc	252..482	CDD:238113	72/240 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910