DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4259 and KLKB1

DIOPT Version :9

Sequence 1:	NP_001259904.1	Gene:	CG4259 / 33385	FlyBaseID:	FBgn0031389	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	272	Identity:	65/272 - (23%)
Similarity:	108/272 - (39%)	Gaps:	62/272 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TTLIISLVNSQYFNYNQIRRETYGSNPRATFPWVVSVLDQRDWLFRYIGVGSLINPNVVLTAAHI 73
            :|.|:...||.:                ..:||.|| |..:....|::..||||....||||||.
Human   399 STRIVGGTNSSW----------------GEWPWQVS-LQVKLTAQRHLCGGSLIGHQWVLTAAHC 446

  Fly    74 LNGTTKYDL------VVRAGEWDTSTTADQQHVDLEVLNIVSHEQFNRFNAENNMALLILVSAFE 132
            .:|....|:      ::...:....|...|      :..|:.|:.:......:::||:      :
Human   447 FDGLPLQDVWRIYSGILNLSDITKDTPFSQ------IKEIIIHQNYKVSEGNHDIALI------K 499

  Fly   133 MTANINLI----PLYLQEAGIQK---GSCFFNGWGKVYLNSTDYPTVLKTVQVDLLSMGMCSSR- 189
            :.|.:|..    |:.|...|...   .:|:..||| ......:...:|:.|.:.|::...|..|
Human   500 LQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWG-FSKEKGEIQNILQKVNIPLVTNEECQKRY 563

  Fly   190 ---KLPIQQICGKGLEG--IDCSGDGGAPLVCRILTYPYKYAQVGIVNW-----LSQKPVENTFI 244
               |:..:.:|....||  ..|.||.|.||||:   :...:..|||.:|     ..::|.
Human   564 QDYKITQRMVCAGYKEGGKDACKGDSGGPLVCK---HNGMWRLVGITSWGEGCARREQPG----- 620

  Fly   245 VFTNVAGLLPWI 256
            |:|.||..:.||
Human   621 VYTKVAEYMDWI 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4259	NP_001259904.1	Tryp_SPc	39..259	CDD:238113	61/242 (25%)
CG4259	NP_001259904.1	Tryp_SPc	39..256	CDD:214473	59/240 (25%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519
		Tryp_SPc	401..632	CDD:214473	62/268 (23%)
		Tryp_SPc	402..632	CDD:238113	62/267 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910