DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4259 and OVCH2

DIOPT Version :9

Sequence 1:	NP_001259904.1	Gene:	CG4259 / 33385	FlyBaseID:	FBgn0031389	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	XP_016873148.1	Gene:	OVCH2 / 341277	HGNCID:	29970	Length:	569	Species:	Homo sapiens

Alignment Length:	277	Identity:	81/277 - (29%)
Similarity:	129/277 - (46%)	Gaps:	42/277 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SLVNSQYFNYNQIRRETYGSN--PRATFPWVVSVLDQRDWLFRYIGVGSLINPNVVLTAAH-ILN 75
            |||..|.:||..|.....|.:  .:.::||.|| |.||.   ::|..||:::|..|:|||| |.|
Human    40 SLVKVQPWNYFNIFSRILGGSQVEKGSYPWQVS-LKQRQ---KHICGGSIVSPQWVITAAHCIAN 100

  Fly    76 GTTKYDLVVRAGEWDTSTTADQQHVDLEVLNIVSHEQFN-RFNAENNMALLILVSAFEMTANINL 139
            ......|.|.|||:|.|.| |.....|.:..::.|..|: :...:.::|||.:..||:....:.
Human   101 RNIVSTLNVTAGEYDLSQT-DPGEQTLTIETVIIHPHFSTKKPMDYDIALLKMAGAFQFGHFVG- 163

  Fly   140 IPLYLQ------EAGIQKGSCFFNGWGKVYLNSTDYPTVLKTVQVDLLSMGMCSSRKLPIQQ-IC 197
             |:.|.      |||.   .|...|||::..... ...||:.|.:.:|:...|.:..|.::: |.
Human   164 -PICLPELREQFEAGF---ICTTAGWGRLTEGGV-LSQVLQEVNLPILTWEECVAALLTLKRPIS 223

  Fly   198 GKGL-------EGID-CSGDGGAPLVCRILTYPYKYAQVGIVNW----------LSQKPVENTFI 244
            ||..       .|.| |.||.|..|:||.....:..|  |:.:|          ..:|..:.:..
Human   224 GKTFLCTGFPDGGRDACQGDSGGSLMCRNKKGAWTLA--GVTSWGLGCGRGWRNNVRKSDQGSPG 286

  Fly   245 VFTNVAGLLPWIDYHLR 261
            :||:::.:||||..|::
Human   287 IFTDISKVLPWIHEHIQ 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4259	NP_001259904.1	Tryp_SPc	39..259	CDD:238113	72/246 (29%)
CG4259	NP_001259904.1	Tryp_SPc	39..256	CDD:214473	70/243 (29%)
OVCH2	XP_016873148.1	Tryp_SPc	55..298	CDD:214473	71/255 (28%)
		Tryp_SPc	56..301	CDD:238113	73/257 (28%)
		CUB	320..424	CDD:238001
		CUB	435..546	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910