DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4259 and F12

DIOPT Version :9

Sequence 1:	NP_001259904.1	Gene:	CG4259 / 33385	FlyBaseID:	FBgn0031389	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_000496.2	Gene:	F12 / 2161	HGNCID:	3530	Length:	615	Species:	Homo sapiens

Alignment Length:	241	Identity:	73/241 - (30%)
Similarity:	108/241 - (44%)	Gaps:	26/241 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RATFPWVVSVLDQRDWLFRYIGVGSLINPNVVLTAAHIL-NGTTKYDLVVRAGEWDTSTTADQQH 99
            |...|::.::.    |...:. .||||.|..||||||.| :.....||.|..|:...:.:.:...
Human   381 RGAHPYIAALY----WGHSFC-AGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQ 440

  Fly   100 VDLEVLNIVSHEQFNRFNAENNMALLILVSAFEMTANINLIPLYLQEAGIQKGS--------CFF 156
            . |.|.:...||.|:..:.::::|||.|..  :...:..|:..|:|...:..|:        |..
Human   441 T-LAVRSYRLHEAFSPVSYQHDLALLRLQE--DADGSCALLSPYVQPVCLPSGAARPSETTLCQV 502

  Fly   157 NGWGKVYLNSTDYPTVLKTVQVDLLSMGMCS------SRKLPIQQICGKGLE-GID-CSGDGGAP 213
            .|||..:..:.:|.:.|:..||..||:..||      |..|| ..:|...|| |.| |.||.|.|
Human   503 AGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILP-GMLCAGFLEGGTDACQGDSGGP 566

  Fly   214 LVCRILTYPYKYAQVGIVNWLSQKPVENTFIVFTNVAGLLPWIDYH 259
            |||.......:....||::|.|.....|...|:|:||..|.||..|
Human   567 LVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREH 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4259	NP_001259904.1	Tryp_SPc	39..259	CDD:238113	71/236 (30%)
CG4259	NP_001259904.1	Tryp_SPc	39..256	CDD:214473	69/233 (30%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		Kringle	217..295	CDD:278480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359
		Tryp_SPc	372..609	CDD:214473	70/236 (30%)
		Tryp_SPc	373..612	CDD:238113	72/239 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910