DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and BAG3

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_004272.2	Gene:	BAG3 / 9531	HGNCID:	939	Length:	575	Species:	Homo sapiens

Alignment Length:	324	Identity:	71/324 - (21%)
Similarity:	110/324 - (33%)	Gaps:	126/324 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 QLQTQPADDEPLPAGWEIRLD-QYGRRYYVDHNTRSTYWEKP---------TP------------ 396
            |:.:...|.:|||.||||::| |.|..::||||:|:|.|..|         ||
Human    11 QVASGNGDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPSEGPKETPSSANGPSREGSR 75

  Fly   397 LPPGWEIRKDGRGRVYYVDHNTRKTTWQRPN--SERLMH--FQHWQGQRAHVVSQ-GNQRYLYSQ 456
            |||..|      |...|..        .||.  ...::|  .::.|....||..| |.||:
Human    76 LPPARE------GHPVYPQ--------LRPGYIPIPVLHEGAENRQVHPFHVYPQPGMQRF---- 122

  Fly   457 QQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEG 521
                .|...|...|..:..|..:|:                    |||   |..|..:|:
Human   123 ----RTEAAAAAPQRSQSPLRGMPE--------------------TTQ---PDKQCGQVA----- 155

  Fly   522 PLPPGWEIRYTAAGERFFVDHNTRRTTFEDPR-------------PGAPKGAKGVYGVPRAYERS 573
                      .||..:....|...|:  :.|.             |.:.:.:.|.:.:||.|
Human   156 ----------AAAAAQPPASHGPERS--QSPAASDCSSSSSSASLPSSGRSSLGSHQLPRGY--- 205

  Fly   574 FRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMR--LPA----YELRRRLYIIFRGEE 631
                          .::|...:..|||... :.|:||..:  .||    |:..:.:|...:|::
Human   206 --------------ISIPVIHEQNVTRPAA-QPSFHQAQKTHYPAQQGEYQTHQPVYHKIQGDD 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	18/41 (44%)
		WW	397..426	CDD:278809	6/28 (21%)
		WW	478..509	CDD:197736	4/30 (13%)
		WW	522..554	CDD:197736	5/44 (11%)
		HECTc	594..946	CDD:238033	11/44 (25%)
		HECTc	620..946	CDD:214523	2/12 (17%)
BAG3	NP_004272.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92		29/94 (31%)
		WW	21..53	CDD:197736	17/31 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..200		18/116 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..421		3/15 (20%)
		BAG	421..498	CDD:214591
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900