DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and UBE3B

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_569733.2	Gene:	UBE3B / 89910	HGNCID:	13478	Length:	1068	Species:	Homo sapiens

Alignment Length:	399	Identity:	123/399 - (30%)
Similarity:	200/399 - (50%)	Gaps:	46/399 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 SNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRG-----EEGLDYGGVSREWFFLL 646
            |:|.|....||:.|..:.||.|.|:.:|..:.::..:.:.|..     |.|:|..||.:|:...:
Human   674 SSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEI 738

  Fly   647 SHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYK 711
            ...|.:|...||: ....:..|..:|.||::.::||.|:|:|:.:..|:|.|..:    .:||..
Human   739 IKRVFDPALNLFK-TTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVV----DVPFAS 798

  Fly   712 RMLNKKL---------TIKDIETIDPEFYNSLIWVK--DNNIDECGLELWFSVDFEVLGQIIHHE 765
            ..|::.|         ::.::.::|.|||.:|..:|  |.:|.:.||.|  |.|.:|:||::.||
Human   799 FFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTL--SYDEDVMGQLVCHE 861

  Fly   766 LKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCG 830
            |...|:...||.|||..||.||..:||...|:.||...:.||..::..||::.|...||:.::.|
Human   862 LIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISG 926

  Fly   831 -MQDVDVEDWQRNTI-YRHYNRNSKQVVWFWQFV-RETDNEKRARLLQFVTGTCRVPVGGFAEL- 891
             ..::|:||.:::|: |..::.:.:.::|.|..: .:...::||..|:|||...|.|:.|||.|
Human   927 DNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLK 991

  Fly   892 -------------------MGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLT 937
                               :||.....|.|.|......||.|.||||.|.||.|.....|.|||.
Human   992 PPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLR 1056

  Fly   938 FAIEETEGF 946
            :||....||
Human  1057 YAISMNTGF 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736
		WW	522..554	CDD:197736
		HECTc	594..946	CDD:238033	118/390 (30%)
		HECTc	620..946	CDD:214523	110/364 (30%)
UBE3B	NP_569733.2	HECTc	682..1066	CDD:238033	120/391 (31%)
UBE3B	NP_569733.2	HECTc	707..1065	CDD:214523	110/364 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810