Protein Alignment Su(dx) and RSP5

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_011051.3
• Gene: RSP5 / 856862
• SGDID: S000000927
• Length: 809
• Species: Saccharomyces cerevisiae
• Alignment Length: 958
• Identity: 346/958 - (36%)
• Similarity: 479/958 - (50%)
• Gaps: 212/958 - (22%)

  Fly    52 SVTIE----EASLRNNGFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWNEEFTV-LITPNSTLHF 111
            |::::    |:..:.:.|..|:|:..|.||....:.|...|.:..|.|||.|.. .|..||.|..
Yeast     4 SISVKLVAAESLYKRDVFRSPDPFAVLTIDGYQTKSTSAAKKTLNPYWNETFKFDDINENSILTI 68

  Fly   112 KVLDHSSFRK--DAMLGERIINLAHILQHY-------NGRCEFLELTIDLFVTSKSDNRQTKSGE 167
            :|.|...|:|  ...||...:.:..:|.|.       :||.....:|.||   .||::....||.
Yeast    69 QVFDQKKFKKKDQGFLGVVNVRVGDVLGHLDEDTATSSGRPREETITRDL---KKSNDGMAVSGR 130

  Fly   168 LVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGN 232
            |:.:|       |||        .:.:|..||  ||              |...:.....||:..
Yeast   131 LIVVL-------SKL--------PSSSPHSQA--PS--------------GHTASSSTNTSSTTR 164

  Fly   233 SNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPA 297
            :||..|.|       ....||..|.                   .|:..||..|
Yeast   165 TNGHSTSS-------TRNHSTSHPS-------------------RGTAQAVEST----------- 192

  Fly   298 LARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADD 362
                                  |.:|..||..                  :.:|..:.....:..
Yeast   193 ----------------------LQSGTTAATN------------------TATTSHRSTNSTSSA 217

  Fly   363 EPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPN 427
            ....:.:|   |||||                  ||||||.|.|..||.||||||||.|||:||.
Yeast   218 TRQYSSFE---DQYGR------------------LPPGWERRTDNFGRTYYVDHNTRTTTWKRPT 261

  Fly   428 SERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQP-------------TAVTAQV----------- 468
            .::.      :.:|      |||....::.:::.             ::||.||
Yeast   262 LDQT------EAER------GNQLNANTELERRQHRGRTLPGGSSDNSSVTVQVGGGSNIPPVNG 314

  Fly   469 --------TQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPR--------------TQ 511
                    |......||.||.|||::...:.|.|||:|..|||.|.|||              .|
Yeast   315 AAAAAFAATGGTTSGLGELPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQ 379

  Fly   512 GQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRW 576
            .|.||.:  ||||.|||:|.|.....:||||||:.||::|||  .|....  ..||: |:|.||.
Yeast   380 QQPVSQL--GPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPR--LPSSLD--QNVPQ-YKRDFRR 437

  Fly   577 KLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSRE 641
            |:..||.......||....|.|.|:.:|||:|.:|||....:|::||.|.|.|||||||||||||
Yeast   438 KVIYFRSQPALRILPGQCHIKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSRE 502

  Fly   642 WFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFT 706
            :|||||||:.||.||||||:..:||::||||.|.:||:||.|||||||.:.:.::|.||:.:.|.
Yeast   503 FFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFV 567

  Fly   707 MPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGE 771
            ...||.||.||:.::|:|.:|.|.||||.|:.:|:||.. |:|.||.|.|..|:::..:||.:|.
Yeast   568 GALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLENSIDGV-LDLTFSADDERFGEVVTVDLKPDGR 631

  Fly   772 KERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDV 836
            ...||:.||:||:.|.|:||:...:::|.|.|::||||::|.:.:..||||||||::.|:.::|:
Yeast   632 NIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDI 696

  Fly   837 EDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFC 901
            |||:::|.||.|..:.:.:.|||:.|.|.|||:|||||||.|||.|:||.||.:|.||:||:||.
Yeast   697 EDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFT 761

  Fly   902 IEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            |||.|:...||:|||||||:|||.|..||.:.:|||.|:|||.||.||
Yeast   762 IEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGFGQE 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	37/134 (28%)
		WW	364..396	CDD:197736	6/31 (19%)
		HUL4	<395..946	CDD:227354	271/596 (45%)
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	344/956 (36%)